A5000331473- Chromatin Remodeling and Cancer
- Computational Drug Discovery Methods
- Protein Degradation and Inhibitors
- Mechanisms of cancer metastasis
- Genomics and Chromatin Dynamics
- Cancer Mechanisms and Therapy
- Ocular Oncology and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- CRISPR and Genetic Engineering
- Neonatal Respiratory Health Research
- Cell Image Analysis Techniques
- Immune cells in cancer
- Genetics, Bioinformatics, and Biomedical Research
- Retinal Development and Disorders
- Smoking Behavior and Cessation
- Urologic and reproductive health conditions
- Birth, Development, and Health
- Cultural Competency in Health Care
- Anesthesia and Sedative Agents
- Skin Protection and Aging
- Biochemical and Molecular Research
- Lipid metabolism and biosynthesis
- RNA regulation and disease
Western Health
2024
Women's and Children's Hospital
2023-2024
Autonomous University of Queretaro
2024
Universitat Jaume I
2024
Cardiff University
2024
Lovelace Respiratory Research Institute
2024
Royal Women's Hospital
2023
University of Hong Kong
2022
Novartis (United States)
2021
Dana-Farber Brigham Cancer Center
2015
Abstract Despite the increasing interest in targeting stromal elements of tumor microenvironment, we still face tremendous challenges developing adequate therapeutics to modify landscape. A major obstacle this is our poor understanding phenotypic and functional heterogeneity cells tumors. Herein, perform an unbiased interrogation mesenchymal cells, delineating co-existence distinct subsets cancer-associated fibroblasts (CAFs) microenvironment murine carcinomas, each endowed with unique...
The human immunodeficiency virus type one integrase (HIV-1 integrase) is required for integration of a double-stranded DNA copy the viral RNA genome into host chromosome and HIV replication. We have previously reported that phenolic moieties in compounds such as flavones, caffeic acid phenethyl ester (CAPE), tyrphostins, curcumin confer inhibitory activity against HIV-1 integrase. investigated actions several recently described protease inhibitors, possessing novel structural features, on...
Abstract SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered novel modulatory function of SHP2. Targeting protein with allosteric inhibitors promoted anti-tumor immunity, including enhancing T cytotoxic immune-mediated regression. Knockout using CRISPR/Cas9 gene editing showed that targeting cancer cells contributes to response. Inhibition activity augmented intrinsic IFNγ signaling resulting enhanced...
Various subunits of mammalian SWI/SNF chromatin remodeling complexes display loss-of-function mutations characteristic tumor suppressors in different cancers, but an additional role for supporting cell survival distinct cancer contexts is emerging. In particular, genetic dependence on the catalytic subunit BRG1/SMARCA4 has been observed acute myelogenous leukemia (AML), yet feasibility direct therapeutic targeting activity remains unknown. Here, we evaluated dual BRG1/BRM ATPase inhibitors...
Abstract Uveal melanoma is a rare and aggressive cancer that originates in the eye. Currently, there are no approved targeted therapies very few effective treatments for this cancer. Although activating mutations G protein alpha subunits, GNAQ GNA11, key genetic drivers of disease, additional drug targets have been identified. Recently, studies identified context-specific roles mammalian SWI/SNF chromatin remodeling complexes (also known as BAF/PBAF) various lineages. Here, we find evidence...
The global mobility of medical student and trainee populations has drawn researchers' attention to consider internationalization in education. Recently, researchers have focused on cultural diversity, predominately drawing Hofstede's cross-cultural analysis dimensions from general population data explain their findings. However, date no research been specifically undertaken examine within a or population. This is problematic as within-country differences between gender professional groups...
Summary Recent evidence suggests that TF may play a causal role in acute coronary syndromes, and be an important therapeutic target. Several inhibitors of TF, coagulation factors VIIa Xa are under investigation as novel antithrombotic approaches. We compared the effects DX-9065a, new FXa inhibitor, vs. enoxaparin. The protocol was open-label crossover study. Subjects (n = 6) participated 3 consecutive study-arms: a) enoxaparin + ASA (1 mg/Kg s. c 162 mg/day X days), b) three escalating doses...
The effects of equipotent doses racemic albuterol and levalbuterol on heart rate (HR) in intensive care patients with without baseline tachycardia were studied. Patients included if they hemodynamically stable required bronchodilator therapy every four hours; excluded maintained a beta-blocker. Four hours after the most recent treatment, each patient was randomized to receive at least two consecutive 2.5 mg or 1.25 apart via nebulization. HR recorded end second dose 5, 10, 15, 30, 60, 90,...
Abstract For a majority of patients with non–small cell lung cancer EGFR mutations, treatment inhibitors (EGFRi) induces clinical response. Despite this initial reduction in tumor size, residual disease persists that leads to relapse. Elucidating the preexisting biological differences between sensitive cells and surviving drug-tolerant persister deciphering how evolve response could help identify strategies improve efficacy EGFRi. In study, we tracked origins clonal evolution at high...
ABSTRACT The general and specific effects of negative affect on adolescent alcohol use were examined among 742 male 1005 female non-Hispanic White 862 1232 Mexican American 9–12th grade students. Standard models indicated that was significantly related to female, but not male, groups. With the controlled, components use, no longer related, amount variance in accounted for by variables small. most consistent pattern occurred between anger use. results indicate unique relate different patterns...
A commercial enzyme-linked immunosorbent assay (ELISA), the SEMA assay, for a seminal vesicle-specific antigen (SVSA) provides highly sensitive detection of semen. Here we show marked interference proteins such as albumin, serum proteins, or mucin with assay. This would substantially decrease sensitivity detecting semen mixed other biological fluids blood vaginal secretions.
To determine the diagnostic accuracy of small-for-gestational-age (SGA; <10th centile) status for infant mortality and adverse school-age outcomes in infants born extremely preterm (EP; <28 weeks' gestation).Geographical cohort studies.The state Victoria, Australia.For mortality, live births 22-27 gestation from 2009 to 2017 offered active care after birth. For outcomes, survivors 8 years' corrected age 1991-1992, 1997 or 2005.SGA centile on four commonly used growth references: three...
<p>Supplementary Figure S1 shows additional shRNA knockdown data in uveal melanoma cell lines. Supplementary S2 dual BRG1/BRM and BRG1 rescue data. S3 basal SWI/SNF subunit expression, caspase activity viability compound treated lines, mutations cells S4 MITF further RNA-Seq ATAC-Seq set analyses. S5 target gene modulation by treatment lines overexpression S6 genomic location of primers used ChIP-qPCR experiment.</p>
<p>Additional method details for ATAC-Seq Data Analysis and ChIP-qPCR</p>
Supplementary Data from Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia
Supplementary Data from Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia
Supplementary Data from Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia
Supplementary Data from Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia