A5079382334- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
- Heat shock proteins research
- Silymarin and Mushroom Poisoning
- Sarcoidosis and Beryllium Toxicity Research
- Peptidase Inhibition and Analysis
- Eosinophilic Disorders and Syndromes
- Multiple Myeloma Research and Treatments
- Polyomavirus and related diseases
- Pleural and Pulmonary Diseases
Tianjin International Joint Academy of Biomedicine
2020-2022
Nankai University
2020-2022
State Key Laboratory of Medicinal Chemical Biology
2020-2022
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease, and the molecular mechanisms remain poorly understood. Our findings demonstrated that pyruvate kinase M2 (PKM2) promoted progression by directly interacting with Smad7 reinforcing transforming growth factor-β1 (TGF-β1) signaling. Total PKM2 expression portion of tetrameric form elevated in lungs fibroblasts were derived from mice bleomycin (BLM)-induced fibrosis. Pkm2 deletion markedly alleviated BLM-induced...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease with multiple causes, characterized by excessive myofibrocyte aggregation and extracellular matrix deposition. Related studies have shown that transforming growth factor-β1 (TGF-β1) key cytokine causing fibrosis, promoting abnormal epithelial-mesenchymal communication fibroblast-to-myofibroblast transition. Fedratinib (Fed) marketed drug for the treatment of primary secondary myelofibrosis, targeting...
Idiopathic pulmonary fibrosis (IPF) is a progressive, life-threatening lung disease characterized by the proliferation of myofibroblasts and deposition extracellular matrix that results in irreversible distortion structure formation focal fibrosis. The molecular mechanism IPF not fully understood, there no satisfactory treatment. However, most studies suggest abnormal activation transforming growth factor-β1 (TGF-β1) can promote fibroblast epithelial to mesenchymal transition (EMT) induce...
Pulmonary fibrosis is a pathological consequence of interstitial pulmonary diseases, and characterized by the persistence fibroblasts excessive deposition extracellular matrix. The etiology multifactorial, role inflammation as an important component in IPF controversial sometimes seen epiphenomenon fibrosis. Stimulus increase production pro-inflammatory cytokines activation NF-κB, which will further promote response myofibroblast transition. Lenalidomide immunomodulatory drug. Previous study...