A5075848492- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Zebrafish Biomedical Research Applications
- Periodontal Regeneration and Treatments
- Neurobiology and Insect Physiology Research
- Dental Trauma and Treatments
- Proteoglycans and glycosaminoglycans research
- Developmental Biology and Gene Regulation
- T-cell and B-cell Immunology
- Osteoarthritis Treatment and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Electrospun Nanofibers in Biomedical Applications
- Occupational Health and Performance
- HIV/AIDS oral health manifestations
- Peripheral Artery Disease Management
- Glycosylation and Glycoproteins Research
- Anesthesia and Pain Management
- Cancer Cells and Metastasis
- Adenosine and Purinergic Signaling
- Diabetic Foot Ulcer Assessment and Management
- Mast cells and histamine
- Renal Transplantation Outcomes and Treatments
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Pediatric health and respiratory diseases
Huadong Hospital
2024
Fudan University
2024
Center for Excellence in Molecular Cell Science
2022
Chinese Academy of Sciences
2022
Second Hospital of Hebei Medical University
2021
Shanxi Medical University
2021
Hebei Medical University
2021
Guhua Hospital
2021
Second Hospital of Shanxi Medical University
2021
Academy of Military Medical Sciences
2014
<title>Abstract</title> Background This study aimed to establish a rat model of thin endometrium and investigate the effects super-activated platelet lysate (sPL) umbilical cord mesenchymal stem cells (UCMSCs) on in rats. Methods Thin models were induced by infusing absolute ethyl alcohol into uteri female Sprague-Dawley (SD) Rats randomly assigned several groups (Normal, Model, Extracellular matrix (ECM) + sPL, ECM cell, Gel cell) treated for 21 or 42 days. Histopathological structures...
Abstract The birth of new neurons and their incorporation into functional circuits in the adult brain is a characteristic many vertebrate invertebrate organisms, including decapod crustaceans. Precursor cells maintaining life‐long proliferation brains crayfish ( Procambarus clarkii, Cherax destructor ) clawed lobsters Homarus americanus reside within specialized niche on ventral surface brain; daughters migrate to two zones along stream formed by processes precursors. Here they divide again,...
Aberrant differentiations of bone mesenchymal stem cells (BMSCs) have proved to be associated with the occurrence senile osteoporosis. However, mechanisms this phenomenon relative abnormal lipid metabolism remain unclear. This study was conducted characterize lipidomics alterations during BMSC passaging, aiming at uncovering aging-related that may play an important role in aberrant BMSCs. Principal component analysis presented sequential passaging. The majority glycerophospholipids,...
Serotonin (5-HT) is a potent regulator of adult neurogenesis in the crustacean brain, as vertebrate brain. However, there are relatively few data regarding mechanisms serotonin's action and which precursor cells targeted. Therefore, we exploited spatial separation neuronal lineage that generates adult-born neurons crayfish (Procambarus clarkii) brain to determine generation(s) influenced by serotonin, identify localize serotonin receptor subtypes underlying these effects.RT-PCR shows mRNAs...
Abstract Background Adult neurogenesis, the production and integration of new neurons into circuits in brains adult animals, is a common feature variety organisms, ranging from insects crustaceans to birds mammals. In mammalian brain 1 st -generation neuronal precursors, astrocytic stem cells, reside neurogenic niches are reported undergo self-renewing divisions, thereby providing source throughout an animal's life. contrast, our work shows that precursors crayfish ( Procambarus clarkii )...
The success of solid organ transplantation (SOT) and the use immunosuppressive agents offer hope to patients with end-stage diseases. However, impact posttransplant diabetes mellitus (PTDM) on SOT has become increasingly evident. In our study, we utilized Scientific Registry Transplant Recipients (SRTR) database investigate association between PTDM patient survival in various types transplantations, including liver, kidney, intestinal, heart, lung, combined heart-lung transplantations (all P...
Mast cells (MCs) are strategically located at the host-environment interface and their non-allergic roles in immune-surveillance of pathogens have recently gained more attention. However, MC-caused detrimental regulation immune inflammations can promote viral invasion. Currently, role MCs retroviral infection remains elusive. We proved that human gut could capture transfer HIV-1 to CD4+ T for promoting spread; MC-released histamine augments HIV-1-induced functional polarization dendritic...
Abstract New neurons are incorporated throughout life into the brains of many vertebrate and nonvertebrate species. This process adult neurogenesis is regulated by a variety external endogenous factors, including environmental enrichment, which increases production in juvenile mice crayfish. The primary goal this study was to exploit spatial separation neuronal precursor cell lineage crayfish determine generation(s) precursors altered conditions. Further, crayfish, an intimate relationship...
The aim of the present study was to evaluate expression inflammasome and cytokine on experimental periodontitis with super activated platelet lysate (SPL) in rats.Periodontitis induced by submerging cotton ligatures right side maxillary second molar 36 Wistar rats. rats were divided into 3 groups randomly: received no treatment (control group); local injection sterile saline (ligature+saline group) SPL (ligature+SPL group). After treatments, alveolar bone level inflammation periodontal...
Abstract This work addresses the cellular localization of heparanase and its colocalization with syndecan‐3, a transmembrane heparan sulfate proteoglycan in spinal cords adult rats. Reverse transcriptase/polymerase chain reaction (RT‐PCR) situ hybridization for transcript revealed expression neurons white matter glia. was confirmed by immunohistochemistry showing cytoplasmic protein. Double immunofluorescence syndecan‐3 proteins cell bodies oligodendrocytes, suggestive constitutive these...
Purpose: To evaluate the effect of super-activated platelet lysate (sPL) on wound healing tooth extraction sockets in rats. Methods: Rat models socket were established. Thirty-six rats divided into control and sPL groups sacrificed days 7, 14, 28 after extraction. Bone formation observed by microscopic computed tomography (micro-CT) hematoxylin eosin (HE) staining; osteoprotegerin (OPG), receptor activator nuclear factor kappa-&Bgr; ligand (RANKL), interleukin 6(IL-6), tumor necrosis...
This study was aimed to investigate the effect of intercellular adhesion molecule-1 (ICAM-1) on migration in vitro murine mesenchymal stem cells (MSC) and its related mechanisms. The ability MSC (C3H10T1/2), ICAM-1 transfected (C3H10T1/2-MIGR1-ICAM-1) empty vector-transfected (C3H10T 1/2-MIGR1) were assayed by using transwell system. Briefly, seeded membrane with 8 µm aperture fetal bovine serum used as chemotactic agent induce migration. transmigrated stained crystal purple well DAPI for h...
Motivation: Both Type 2 Diabetes Mellitus (T2D) and peripheral artery disease (PAD) are linked to impaired mitochondrial function in tissue that may precede micro-vascular disorders. Goal(s): The goal is demonstrate the feasibility of 1H-based MRI for dynamic quantification skeletal muscle PCr (SMPCr) concentration vivo on a 3T clinical system, healthy controls, T2D, PAD. Approach: Dynamic imaging was developed evaluated human subjects rest-exercise-recovery protocol, based Chemical Exchange...
BACKGROUND: Platelet lysate (PL) is considered as an alternative to fetal bovine serum (FBS) and facilitates the proliferation differentiation of mesenchymal cells. OBJECTIVE: The aim this study explore whether super activated platelet (sPL), a novel autologous lysate, has ability inhibit inflammation promote cell proliferation, repair osteogenesis culture medium. METHODS: Different concentrations sPL on human osteoblastic 1.19 line (hFOB1.19) apoptotic were investigated; And detected...
Abstract Background Different basal media have very different effects on cell growth, proliferation and differentiation potential of cultured human umbilical cord mesenchymal stem (hUC-MSC). This issue has not gotten enough research. The goal this study is to select high safety low cost for hUC-MSC, which performs best in combination with commercial platelet lysate product functions, especially suitable high-passage hUC-MSC cultures. Methods Three were combined 5% UltraGROGAdvanced culture...
The aim of this study was to investigate the effects dexmedetomidine on perioperative stress response and cellular immunity in elderly patients with posterior lumbar surgery. Sixty degenerative disease requiring surgery were included randomly divided into group (the test group, [Formula: see text]) control ([Formula: text]). After experimental entered room, intravenously pumped 10[Formula: text]min before induction anesthesia continuously after anesthesia. replaced same amount normal saline,...