A5100457602- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Traditional Chinese Medicine Analysis
- Genomics, phytochemicals, and oxidative stress
- Chromatography in Natural Products
- Cytokine Signaling Pathways and Interactions
- Sirtuins and Resveratrol in Medicine
- Phytochemistry and Bioactive Compounds
- Bioactive Natural Diterpenoids Research
- Natural product bioactivities and synthesis
- Polysaccharides and Plant Cell Walls
- interferon and immune responses
- Cancer therapeutics and mechanisms
- Phytochemical Studies and Bioactivities
- Morinda citrifolia extract uses
- Ocular Diseases and Behçet’s Syndrome
Heilongjiang Bayi Agricultural University
2017-2021
<title>Abstract</title> Background This study aimed to establish a rat model of thin endometrium and investigate the effects super-activated platelet lysate (sPL) umbilical cord mesenchymal stem cells (UCMSCs) on in rats. Methods Thin models were induced by infusing absolute ethyl alcohol into uteri female Sprague-Dawley (SD) Rats randomly assigned several groups (Normal, Model, Extracellular matrix (ECM) + sPL, ECM cell, Gel cell) treated for 21 or 42 days. Histopathological structures...
// Chang Liu 1, * , Hu-Nan Sun Ying-Hua Luo 2, Xian-Ji Piao 3, Dan-Dan Wu 1 Ling-Qi Meng Yue Wang Yi Zhang Jia-Ru Hao Wan-Ting Xu Jin-Qian Li Yang Yi-Qin Ying-Hao Han Gui-Nan Shen Mei-Hua Jin Yan-Qing Zang 4 Jing-Chun 2 Nan-Zhu Fang 5 Yu-Dong Cui and Cheng-Hao Department of Biochemistry Molecular Biology, College Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China Animal Veterinary Medicine, 3 Gynaecology Obstetrics, The Fifth Affiliated Hospital Harbin...
BACKGROUND Quinalizarin (1,2,5,8-tetrahydroxyanthraquinone) exhibits potentially useful anticancer effects by inducing apoptosis in several types of cancer, but its underlying mechanism action remains unknown. The present study examined the quinalizarin on induction cell cycle arrest, apoptosis, generation reactive oxygen species (ROS), other mechanisms, and role modifying colorectal cancer lines. MATERIAL AND METHODS MTT assay was used to evaluate viability SW480 HCT-116 cells that had been...
Derivatives of 1,4‑naphthoquinone have excellent anti‑cancer effects, but their use has been greatly limited due to serious side effects. To develop compounds with decreased effects and improved activity, two novel types derivatives, 2,3‑dihydro‑2,3‑epoxy‑2‑propylsulfonyl‑5,8‑dimethoxy‑1,4‑naphthoquinone (EPDMNQ) 2,3‑dihydro‑2,3‑epoxy‑2‑nonylsulfonyl‑5,8‑dimethoxy‑1,4‑naphthoquinone (ENDMNQ) were synthesized anti‑tumor activities investigated. The EPDMNQ ENDMNQ on cell viability, apoptosis...
The present study investigated the mechanisms of apoptosis induced by cryptotanshinone (CT) in human rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLSs). Cell Counting kit‑8 assay was performed to determine cytotoxic effects CT RA‑FLSs, including primary RA‑FLS, HFLS‑RA and MH7A cells, HFLS cells derived from normal synovial tissue. Annexin V‑FITC/PI staining used detect apoptotic cells. Flow cytometry reactive oxygen species (ROS) levels Western blotting assess expression proteins...
Quinalizarin may be a potential chemical agent for cancer therapy, as it exerts anti‑tumour effects against variety of different types cancer. However, the underlying regulatory mechanism and signalling pathways quinalizarin in lung cells remains unknown. The present study sought to investigate on proliferation, apoptosis reactive oxygen species (ROS) generation MTT assays were used evaluate viability A549, NCI‑H460 NCI‑H23 cells. Flow cytometry was employed cell cycle, ROS A549 Western...
Hit, Lead & Candidate Discovery It is reported that 1,4-naphthoquinones and their derivatives have potent antitumor activity in various cancers, although clinical application limited by observed side effects. To improve the therapeutic efficacy of naphthoquinones treatment cancer to reduce effects, we synthesized a novel naphthoquinone derivative, 2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone (NTDMNQ). In this study, explored effects NTDMNQ on apoptosis gastric cells with focus...