A5102007765- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Endometrial and Cervical Cancer Treatments
- Medical Research and Treatments
- Reconstructive Facial Surgery Techniques
- Cancer Risks and Factors
- Intraperitoneal and Appendiceal Malignancies
- Ear Surgery and Otitis Media
- Traditional Chinese Medicine Studies
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Head and Neck Cancer Studies
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- SARS-CoV-2 and COVID-19 Research
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Inflammatory Myopathies and Dermatomyositis
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Advanced MRI Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Rheumatoid Arthritis Research and Therapies
- Gastrointestinal Tumor Research and Treatment
Henan Provincial People's Hospital
2021-2025
Peking Union Medical College Hospital
2011-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Academy of Medical Sciences
2025
Hubei University
2024
Liaoning Cancer Hospital & Institute
2024
China Medical University
2024
Center for Disease Control
2024
Sichuan Agricultural University
2024
Affiliated Hospital of Hebei University
2023
The pan B-cell surface antigen CD19 is an attractive target for therapeutic monoclonal antibody (mAb) approaches. We have generated a new afucosylated anti-human (hu)CD19 mAb, MEDI-551, with increased affinity to human FcγRIIIA and mouse FcγRIV enhanced antibody-dependent cellular cytotoxicity (ADCC). During in vitro ADCC assays lines, MEDI-551 effective at much lower mAb concentrations than the fucosylated parental anti-CD19-2. Furthermore, depleted B cells from normal donor peripheral...
<b>Objective:</b> To examine the effect of pSer9-GSK-3β on breast cancer and to determine whether underlying metabolic immunological mechanism is associated with ROS/eIF2B natural killer (NK) cells. <b>Methods:</b> We employed TWS119 inactivate GSK-3β by phosphorylating Ser9 explored its NK The expression GSK-3β, group 2 member D (NKG2D) ligands, eIF2B was quantified PCR Western blot. measured intracellular reactive oxygen species (ROS) mitochondrial ROS using DCFH-DA MitoSOX<sup>TM</sup>...
[Abstract] Objective Coronavirus disease 2019 (COVID-19) has become pandemic in the world. The need for IgG-IgM combined antibody test is booming, but data on diagnostic indexes evaluation was inadequate. aim of this study to evaluate a rapid SARS-CoV-2. Methods A total 179 patients were enrolled. Serum collected and corresponding nasal pharyngeal swab specimens SARS-CoV-2 RT-PCR. According RT-PCR results, under categorized as PCR positive group 90 negative 89 patients. Results 1. Of...
Abstract Introduction The survival benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) has been well defined at the time interval cytoreductive surgery, but role HIPEC remains uncertain for patients with newly diagnosed advanced ovarian cancer in upfront setting. present study aimed to report updated long‐term outcomes after 5 years follow‐up from our previous multicenter retrospective cohort compare primary surgery (PCS) plus PCS alone among women stage III epithelial cancer....
Coronary atherosclerosis (CA) is a chronic cardiovascular disease characterized by the accumulation of lipid plaques in coronary arteries, leading to vascular narrowing and impaired myocardial blood supply, which can result severe complications, such as angina infarction, may even be life-threatening. Despite advancements CA treatment, including medication surgery, complex mechanisms plaque formation some patients responding poorly existing therapies, specific targets for precision treatment...
This study examines the perceived impact of Generative Artificial Intelligence (AI) on teaching materials among Traditional Chinese Medicine (TCM) educators in Shandong, China. A quantitative survey design was employed, utilizing a structured questionnaire to assess AI’s influence accuracy, creativity, structure, and efficiency instructional material development. Demographic variables, including age, gender, years experience, frequency AI usage, were also analyzed identify potential...
Neural stem cell (NSC)-based therapies offer potential for neural repair in central nervous system (CNS) inflammatory and degenerative disorders. Typically, these conditions present with multifocal CNS lesions making it impractical to inject NSCs locally, thus mandating optimization of vascular delivery the cells involved sites. Here, we analyzed expression molecular effectors migration found that are natively devoid E-selectin ligands. Using glycosyltransferase-programmed stereosubstitution...
// Chang Liu 1, * , Hu-Nan Sun Ying-Hua Luo 2, Xian-Ji Piao 3, Dan-Dan Wu 1 Ling-Qi Meng Yue Wang Yi Zhang Jia-Ru Hao Wan-Ting Xu Jin-Qian Li Yang Yi-Qin Ying-Hao Han Gui-Nan Shen Mei-Hua Jin Yan-Qing Zang 4 Jing-Chun 2 Nan-Zhu Fang 5 Yu-Dong Cui and Cheng-Hao Department of Biochemistry Molecular Biology, College Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China Animal Veterinary Medicine, 3 Gynaecology Obstetrics, The Fifth Affiliated Hospital Harbin...
Tau, a microtubule binding protein, is not only major component of neurofibrillary tangles in Alzheimer's disease, but also causative gene for hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). We show here that an FTDP-17 tau mutation (V337M) SH-SY5Y cells reduces polymerization, increases voltage-dependent calcium current (ICa) density, decreases ICa rundown. The reduced rundown by V337M was significantly inhibited nifedipine (L-type Ca channel blocker),...
To evaluate the significance of red blood cell distribution width (RDW) and other factors for disease activity in rheumatoid arthritis (RA).Each patient underwent clinical examination sampling assessment serum high-sensitivity C-reactive protein (hs-CRP) levels, erythrocyte sedimentation rate (ESR), hemoglobin concentration (Hb), hematocrit (HCT), RDW, parameters (mean corpuscular volume [MCV], mean Hb [MCH], [MCHC]). Rheumatoid (RF-IgA, -IgG, -IgM) anti-cyclic citrullinated antibodies...
Abstract Background Neoadjuvant chemotherapy followed by cytoreduction surgery has been used where an accurate cytologic or pathologic diagnosis is usually required before the initiation of neoadjuvant chemotherapy. However, it difficult to make definitive presence cancer cells, particularly gynecologic versus non-gynecologic origin, from those ascites specimens due absence specific biomarkers cancers. In present study, we evaluated if, in addition routine morphologic diagnosis, biomarker...
Derivatives of 1,4‑naphthoquinone have excellent anti‑cancer effects, but their use has been greatly limited due to serious side effects. To develop compounds with decreased effects and improved activity, two novel types derivatives, 2,3‑dihydro‑2,3‑epoxy‑2‑propylsulfonyl‑5,8‑dimethoxy‑1,4‑naphthoquinone (EPDMNQ) 2,3‑dihydro‑2,3‑epoxy‑2‑nonylsulfonyl‑5,8‑dimethoxy‑1,4‑naphthoquinone (ENDMNQ) were synthesized anti‑tumor activities investigated. The EPDMNQ ENDMNQ on cell viability, apoptosis...
The development of digital technologies such as blockchain has provided new possibilities for solving the financing difficulties small and medium-sized enterprises (SMEs). In order to explore mutual influence participants in supply chain, this paper constructs two static tripartite game models traditional chain finance, including a enterprise (SME), core (CE), financial institution (FI). conditions SME, CE, FI participate equilibrium strategy (repayment, repayment, loan) after participating...
To review the application of radiomics in gastric cancer and its challenges as well future prospects.A research for relevant studies were performed PubMed with terms "radiomics," "texture analysis," "gastric cancer." The search was updated until February 28, 2019.All original articles regarding investigation texture analysis or retrieved. Only papers written English included.A total 17 selected final. It is shown that has yielded moderate to excellent performance a spectrum respects...
Mesenchymal stem cell (MSC) infusion may reduce myocardial ischemic injury. TNF-alpha is a proinflammatory cytokine produced in large quantities during ischemia that can exert beneficial or detrimental effects on MSC function by binding to 55-kd receptor (TNFR1) 75-kd (TNFR2) MSCs. We investigated whether genetic modification with ablation of TNFR1 and/or TNFR2 affects MSC-mediated protection against The MSCs were harvested from wild-type mice (WT-MSCs) and knockout (TNFR1KO, TNFR2KO,...