Gastric cancer (GC) is a common malignancy and frequent cause of cancer-related death. Long non-coding RNAs (lncRNAs) have emerged as important regulators tissue-specific biomarkers multiple cancers, including GC. Recent evidence has indicated that the novel lncRNA LINC01133 plays an role in progression metastasis. However, its function molecular mechanism GC remain largely unknown. expression was detected 200 matched non-cancerous tissues by quantitative reverse transcription PCR. Gain-...

Abstract Esophageal squamous cell carcinoma (ESCC) is one of the leading causes cancer-related death, especially in China. In addition, prognosis late stage patients extremely poor. However, biological significance long non-coding RNA lnc-ATB and its potential role ESCC remain to be documented. this study, we investigated underlying mechanism promoting oncogenic activity ESCC. Expression was higher tissues lines than that normal counterparts. Upregulated served as an independent predictor...

// Xiaoliang Wu 1, 2, * , Xiaoxiao Dinglin 3, Xing Wang Wen Luo 1 Qi Shen Yong Li Ling Gu 4 Qianghua Zhou 2 Haotu Zhu Yanjie 5 Chaodi Tan 6 Xianzi Yang 7 and Zhenfeng Zhang 8, Department of Oncology, Guizhou Provincial People’s Hospital, Guiyang, China State Key Laboratory Oncology in South & Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Center, Guangzhou, 3 Medical Memorial University, Puer Puer, The Third Affiliated Hospital Institute Guangzhou 8...

A recent study has demonstrated that the long non-coding RNA VPS9D1-AS1 is highly expressed in colorectal cancer and predicts poor prognosis. However, roles of gastric remained poorly understood.The aim this to decipher expression (GC) patients, so as assess whether or not it could be used a novel biomarker for prognosis patients.The was examined tissues paired adjacent non-tumorous from 126 patients using qRT-PCR. Correlations between clinicopathological parameters patients' survival were...

Background/Aims: The development of multidrug resistance (MDR), which results in disease recurrence and metastasis, is a crucial obstacle to successful chemotherapy for patients with gastric cancer (GC). Long non-coding RNAs (lncRNAs) have been found play various roles cancer. This study aimed investigate the effect XLOC_006753 on MDR GC cells. Methods: expression levels cell lines (SGC-7901/5-FU SGC-7901/DDP line) were assessed by qRT-PCR. Statistical analyses conducted determine...

Intestinal injury has long been considered to play a crucial role in the pathophysiology of sepsis and even characterized as "motor" it. Thus, we explored effects connexin43 (Cx43) on sepsis-induced intestinal order provide potential therapeutic strategies. Rat cecal ligation puncture (CLP) models vivo cell (IEC-6 cells) pretreated with LPS vitro were used current study. Firstly, different methods, such Cx43 inhibitors (18-α-GA oleamide) or siRNA targeting N-acetyl cysteine (NAC) (a kind ROS...

NORAD (non-coding RNA-activated by DNA damage) is a conserved, abundant, and broadly expressed long non-coding RNA, which functions to preserve genome stability. However, its prognostic significance in esophageal squamous cell carcinoma (ESCC) remains unclear.The expression of was detected quantitative real-time polymerase chain reaction pairs tumorous adjacent normal tissues derived from 106 ESCC patients. We analyzed the potential relationship between levels tumor clinicopathological...

// Jia-Hong Wang 1, * , Hong-sheng Tang Xiao-Shan Li 2, Xiang-Liang Zhang 1 Xian-Zi Yang Li-Si Zeng Qiang Ruan Yong-Hong Huang Gao-Jie Liu Jin ** and Shu-Zhong Cui Department of Abdominal Surgery, Affiliated Cancer Hospital & Institute Guangzhou Medical University, Guangzhou, 510095, Guangdong, China 2 Oncology, These authors have contributed equally to this work jointly supervised Correspondence to: Cui, email: cuishuzhong@126.com Wang, gdwjin@126.com Keywords: FOXO6, gastric cancer,...

Abstract Introduction The survival benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) has been well defined at the time interval cytoreductive surgery, but role HIPEC remains uncertain for patients with newly diagnosed advanced ovarian cancer in upfront setting. present study aimed to report updated long‐term outcomes after 5 years follow‐up from our previous multicenter retrospective cohort compare primary surgery (PCS) plus PCS alone among women stage III epithelial cancer....

Objective: Organoids have recently been used as in vitro models to screen chemotherapy drugs combination with hyperthermiatreatment colorectal cancer. Our research aimed establish a library of patient-derived cancer organoids evaluatesynergism between and hyperthermia; validate an index the hyperthermia sensitizationenhancement ratio (HCSER) identify chemotherapeutics most enhanced by recommend chemotherapydrugs for hyperthermic intraperitoneal treatment. Methods: were grown from cells...

Human epidermal growth factor receptor 2 (HER-2) has an important clinical role in various cancers. However, the prognostic impact of HER-2 gastric cancer (GC) is controversial. RAB1A small molecule mechanistic target rapamycin signalling pathway, which one downstream pathways family. In recent years, aberrant expression been reported a number tumours, but its regulation GC not extensively examined. Therefore, present study investigated pattern and significance adenocarcinoma (CAG). A...

Considerable evidence indicates that long noncoding RNAs (lncRNAs) exert importantly regulatory functions during human cancer initiation and progression are promising biotargets in the flight against cancer.In this study, we evaluated role of lncRNA LINC01133 esophageal squamous cell carcinoma (ESCC). expression ESCC was examined by quantitative real-time PCR. The correlations between clinicopathological variables survival were χ2 test, Kaplan-Meier method, log-rank univariate Cox regression...

Many articles have reported that Rab1A was overexpressed in a variety of human cancers and involved tumor progression metastasis. However, the biological function molecular mechanism nasopharyngeal carcinoma (NPC) remained unknown until now. Here we found overexpression is common event positively associated with distant metastasis poor prognosis NPC patients. Functionally, depletion inhibited migration EMT phenotype cells, whereas led to opposite effect. Furthermore, reveal an important role...

Gastric cancer (GC) is one of the most common malignant tumors globally. About 20–30% patients with gastric show peritoneal implantation metastasis at first diagnosis. Peritoneal responsible for 70% deaths advanced cancer. Although there are many ways to treat cancer, prognosis recurrence unsatisfactory. An auxiliary treatment hyperthermic intraperitoneal chemotherapy (HIPEC), an internationally recognized recommended A series clinical trials have shown that HIPEC significantly improves...

Gamma-glutamyltransferase (GGT) is a membrane-bound enzyme involved in the metabolism of glutathione. Studies suggested that GGT played an important role tumor development, progression, invasion and drug resistance prognosis. The association between prognosis patients with nasopharyngeal carcinoma (NPC) was unknown. This study conducted to investigate pretherapeutic serum level clinical-pathological parameters survival NPC.Two hundred twenty-two NPC were recruited this stratified into two...

LINC00323 is a novel lncRNA which has reported to play an important role in the development and recurrence several cancers. However, expression predictive value of gastric cancer (GC) remain mysterious.LINC00323 GC tissues adjacent normal was evaluated by quantitative reverse-transcription PCR (qRT-PCR). The relationship between clinicopathological features patients' survival were analyzed. Univariate multivariate analyses performed.LINC00323 found be significantly increased tissues. High...

Cripto-1 may act as an independent predictor for prognosis in hepatocellular carcinoma (HCC).However, the function of HCC cells and its response to postoperative transarterial chemoembolization (TACE) patients remains unclearly.Up-regulated expression boosted ability cell proliferation, migration invasion vitro.While opposite results were observed with downregulated expression.Cripto-1 was correlated epithelial-mesenchymal transition (EMT) relevant biomarkers.Furthermore, high patients,...

To analyze the characteristics and factors affecting recurrence in esophageal cancer within first year after esophagectomy.We reviewed retrospectively clinical follow-up data of 320 patients who underwent surgical treatment from April 2009 to 2013 Sichuan Provincial Cancer Hospital.72 cases (72/320, 22.5%) had tumor surgery. The average time was 6.89±3.53 months median 6.02 months. Univariate analysis showed that T stage, N G grade, pathological stage are related (P<0.05 for all). Logistic...

To explore the clinical characteristics, pathological features, and diagnosis treatment strategies of nasal chondromesenchymal hamartoma (NCMH) in infants young children.

Abstract Background:Hepatocellular carcinoma (HCC) is an aggressive with genome instability. Long non-coding RNAs (LncRNAs) have been functionally associated genomic instability in cancers. However, the identification and prognostic value of lncRNAs related to not explored hepatocellular carcinoma. In this study, we aim identify a instability-related lncRNA signature for predicting prognosis efficacy immunotherapy HCC patients.Methods:According somatic mutation transcript data 364 patients...

Abstract Background: Rab1A has recently been shown to act as an oncogene and promote colorectal liver tumorigenesis. In this study, we aim understand the potential role of its homolog Rab1B in esophageal squamous cell carcinoma (ESCC) underlying molecular mechanisms. Methods: The expressions in139 paired human ESCC tissues adjacent normal were evaluated by immunohistochemistry. A series vitro vivo assays performed elucidate biological functions Rab1B, their regulation mTOR signaling,...