A5052925846- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Chemokine receptors and signaling
- Protease and Inhibitor Mechanisms
- Bone health and treatments
- Medical Imaging and Pathology Studies
- Sarcoma Diagnosis and Treatment
- Genital Health and Disease
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Urological Disorders and Treatments
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Management of metastatic bone disease
- Advanced Proteomics Techniques and Applications
- Urologic and reproductive health conditions
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cancer Cells and Metastasis
- Female Genital Mutilation/Cutting Issues
- Ferroptosis and cancer prognosis
Sun Yat-sen University
2015-2025
Sun Yat-sen University Cancer Center
2015-2025
Southwest Forestry University
2024
State Key Laboratory of Oncology in South China
2016-2022
Southern Medical University
2015-2016
The premetastatic niche (PMN) contributes to lung-specific metastatic tropism in osteosarcoma. However, the crosstalk between primary tumor cells and lung stromal is not clearly defined. Here, we dissect composition of immune PMN identify granulocytic myeloid-derived suppressor cell (gMDSC) infiltration as positively associated with immunosuppressive formation colonization. Osteosarcoma-cell-derived extracellular vesicles (EVs) activate interstitial macrophages initiate influx gMDSCs via...
Abstract Cooperation between primary malignant cells and stromal can mediate the establishment of lung metastatic niches. Here, we characterized landscape cell populations in tumor microenvironment treatment-naïve osteosarcoma using single-cell RNA sequencing identified a stem cell–like cluster with cell–initiating properties prometastatic traits. CXCL14 was specifically enriched also significantly upregulated metastases compared tumors. induced reprogramming evoked phenotype fibroblasts to...
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the leading causes cancer-related death, especially in China. In addition, prognosis late stage patients extremely poor. However, biological significance long non-coding RNA lnc-ATB and its potential role ESCC remain to be documented. this study, we investigated underlying mechanism promoting oncogenic activity ESCC. Expression was higher tissues lines than that normal counterparts. Upregulated served as an independent predictor...
Tumor-infiltrating immune cells play a crucial role in tumor progression and response to treatment. However, the limited studies on infiltrating have shown inconsistent even controversial results for osteosarcoma (OS). In addition, dynamic changes of after neoadjuvant chemotherapy are largely unknown. We downloaded RNA expression matrix clinical information 80 OS patients from TARGET database. CIBERSORT was used evaluate proportion 22 cell types based gene data. M2 macrophages were found be...
Despite its rare incidence worldwide, penile squamous cell carcinoma (PeSCC) still presents with significant morbidity and mortality due to the limited treatment options for advanced patients, especially those in developing countries. The program death-1 (PD-1)/PD-1 ligand (PD-L1) axis has been demonstrated play an important role tumor immune escape, immunotherapies targeting this pathway have shown great success certain cancer types. Here, we analyzed expression pattern of PD-L1 cells...
Soft tissue sarcomas (STS) are highly malignant tumors with limited treatment options owing to their heterogeneity and resistance conventional therapies. Photodynamic therapy (PDT) poly-ADP-ribose polymerase (PARP) inhibitors (PARPi) have shown potential for STS treatment, PDT being effective located on the extremities body surface PARPi targeting defects in homologous recombination repair. To address limitations of harness PARPi, herein, a novel therapeutic approach combining nanocapsules...
Background: Osteosarcoma (OSA), the most common primary bone malignancy in children and adolescents, is prone to metastases unfavorable prognosis. Owing its strong genomic heterogeneity, traditional chemotherapy, or targeted immunotherapy has not effectively improved related overall survival for decades. Since landscape of OSA tumor immune microenvironment scarcely known, despite it playing a crucial role predicting clinical outcomes therapeutic efficacies, we aimed elucidate molecular...
Patients with non-small cell lung cancer (NSCLC) brain metastases (BM) have poor clinical outcomes. We sought to determine if AXL–GAS6 expression can be used as independent prognostic biomarkers for NSCLC BM. retrospectively studied the medical records of 98 patients diagnosed advanced metastatic from December 2000 June 2014. Out a total metastases, 66 were identified metastases. The expressions AXL and GAS6 assessed by standard immunohistochemistry correlated clinicopathological factors...
Study Design. A retrospective study was conducted. Objective. This aims to compare the perioperative outcomes of minimal invasive spine surgery (MISS) and traditional open (TOS) for thoracolumbar metastasis. Summary Background Data. TOS metastatic spinal tumors has many disadvantages, such as significant blood loss high complication rate. MISS may change treatment modality, but its safety efficacy metastasis are lacking. Methods. We retrospectively reviewed clinical data from 154 consecutive...
To explore the efficacy and safety of lenvatinib, either as a monotherapy or in combination with programmed death-1 (PD-1) blockades, re-challenging treatment patients metastatic osteosarcoma following failure previous tyrosine kinase inhibitors (TKIs). We retrospectively reviewed data 26 who received rechallenge lenvatinib plus PD-1 blockades after initial TKI from January 2020 to June 2024 our center. The primary endpoint was progression-free survival (PFS). Secondary endpoints included...
Abstract Background Indoleamine 2,3‐dioxygenase 1 (IDO1) and tryptophan (Trp) catabolism have been demonstrated to play an important role in tumor immunosuppression. This study examined the expression catalytic activity of IDO1 penile squamous cell carcinoma (PSCC) explored their clinical significance. Methods level, serum concentrations Trp kynurenine (Kyn) were 114 PSCC patients by immunohistonchemistry solid‐phase extraction‐liquid chromatography‐tandem mass spectrometry. The survival was...
Abstract Background The poor overall survival of osteosarcoma (OS) underscores the need to explore new therapeutic avenues. Tumor necrosis rate (TNR) after neoadjuvant chemotherapy predicts prognosis. Aims study was investigate safety and activity with camrelizumab (a humanized antibody against PD‐1) in patients resectable OS. Materials & Methods We conducted a prospective, single‐arm, exploratory phase II trial OS patients. Eligible received combined doxorubicin or liposomal...
Osteosarcoma (OSA) is the most common bone malignancy and displays high heterogeneity of molecular phenotypes. This study aimed to characterize features OSA by developing a classification system based on gene expression profile tumor microenvironment. Integrative analysis was performed using specimens clinical information for patients from TARGET program. Using matrix factorization method, we identified two subtypes significantly associated with prognosis, S1 (infiltration type) S2 (escape...
To evaluate the relevance of C-reactive protein (CRP) and squamous cell carcinoma antigen (SCC-Ag) levels in relation to clinicopathological factors prognosis penile cancer.A total 124 Chinese patients with (SCC), treated between November 2007 October 2014, were analysed retrospectively. Receiver-operating characteristic curves used identify combination markers best sensitivity specificity for prediction. Statistical data analysis was performed using a non-parametric method, survival...
Human papillomavirus (HPV) is a significant etiologic driver of penile squamous cell carcinoma (PSCC). The integration pattern HPV and its carcinogenic mechanism in PSCC remain largely unclear. We retrospectively reviewed 108 cases who received surgery between 2008 2017. Using high-throughput viral detection, we identified 35 HPV-integrated PSCCs. Unlike cervical cancer, the E2 oncogene was not prone to involvement integration. Eleven (31.4%) PSCCs harbored intact E2; these tumors had lower...
Minimally invasive separation surgery (MISS) is a safe and effective surgical technique, the current optimal treatment for spinal metastases. However, learning curve this technique has not been analyzed. This study aimed to define analyze of MISS metastases with small incision freehand pedicle screw fixation.A continuous series 62 patients who underwent were included. Each patient's operative data accurately counted. The improvement patients' neurological function was followed up after...
// Jieping Chen 1, 2, * , Kai Yao Zaishang Li 2 Chuangzhong Deng Liangjiao Wang 3 Xingsu Yu 4 Peili Liang 5 Qiankun Xie Peng 6 Zike Qin Yunlin Ye Zhuowei Liu Fangjian Zhou Zhenfeng Zhang Hui Han 1 Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Medicine, Guangzhou, China Department Urology, Endocrinology, The First Affiliated Hospital University, Medical Imaging & Image-Guided Therapy, Gynecology, Memorial Hospital,...
Tumor microenvironments are strongly related to tumor development, and immune-infiltrating cells immune-related molecules potential prognostic markers. However, the shortcomings of traditional measurement methods limit accurate evaluation various components in microenvironments. With rapid advancement Next-Generation RNA Sequencing technology, dedicated in-depth analyses immune filtration within microenvironment has been achieved. In this study, we combined bioinformatics analysis ESTIMATE,...
In the present study, we aim to compare rationality of proposed N classification based on number metastatic lymph nodes (LNs) with current one. A total 509 penile cancer patients at our institute were analyzed. Univariable and multivariable statistical analyses used assess cancer-specific survival (CSS) in 2 staging systems. Harrell's concordance index was applied evaluate predictive accuracy predicting CSS. We propose a new classification: pN1 (metastasis 1-2 regional LNs), pN2 3 LNs, or...