A5062769133- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Protein Structure and Dynamics
- Cancer, Lipids, and Metabolism
- Nuclear Structure and Function
- RNA modifications and cancer
- Heat shock proteins research
- Bioinformatics and Genomic Networks
- DNA and Nucleic Acid Chemistry
- Genomics and Chromatin Dynamics
- Gold and Silver Nanoparticles Synthesis and Applications
- Lipid metabolism and biosynthesis
- Gut microbiota and health
- Species Distribution and Climate Change
- Inorganic Chemistry and Materials
- Liver Disease Diagnosis and Treatment
- Metalloenzymes and iron-sulfur proteins
- Nuts composition and effects
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Machine Learning in Bioinformatics
- Acute Kidney Injury Research
- 2D Materials and Applications
- vaccines and immunoinformatics approaches
Peking University
2019-2025
Anhui Medical University
2025
National Health and Family Planning Commission
2022-2025
Columbia University
2024
Beijing National Laboratory for Molecular Sciences
2021
Xuzhou Medical College
2018
Harbin Medical University
2011
South China University of Technology
2007
Protein self-assembly is one of the formation mechanisms biomolecular condensates. However, most phase-separating systems (PS) demand multiple partners in biological conditions. In this study, we divided PS proteins into two groups according to mechanism by which they undergo PS: PS-Self can self-assemble spontaneously form droplets, while PS-Part interact with PS. Analysis amino acid composition revealed differences sequence pattern between protein groups. Existing predictors, when...
Phase separation (PS) proteins form droplets to regulate myriad membraneless organelles (MLOs) and cellular pathways such as transcription, signaling transduction protein degeneration. PS are usually liquid-like can convert hydrogel/solid-like under certain conditions. The behavior of is regulated by co-PS partners mutations, modifications, oligomerizations, repeat regions alternative splicing the proteins. With growing interest in condensates associated proteins, we established PhaSepDB...
In this study, silver nanoparticles were formed on a natural macroporous matrix, the stem of rice-paper plant, by reducing Ag+ in aqueous solution through situ processing without using any other stabilizers. The pores with their size about 100 µm, thought to act as reaction compartments for nucleation and growth nanoparticles, control crystal during reduction was found be important successful formation nanosized particles onto matrix. diameter amount resultant can controlled changing...
The study investigated the protective effect of walnut oligopeptides (WOPs) against ethanol-induced gastric injury using Sprague-Dawley (SD) rats. Rats were randomly divided into seven groups based on body weight (10/group), normal group, ethanol whey protein group (220 mg/kg weight), omeprazole (20 and three WOPs (220, 440, 880 weight). After 30 days treatment with WOPs, rats given 5 mL/kg absolute by gavage to induce mucosal injury. Gastric ulcer index (GUI) determined following measured;...
Liquid-liquid phase separation (LLPS) is an important organizing principle for biomolecular condensation and chromosome compartmentalization. However, while many proteins have been reported to undergo LLPS, quantitative global analysis of chromatin LLPS property remains absent.Here, by combining chromatin-associated protein pull-down, proteomics 1,6-hexanediol (1,6-HD) treatment, we develop Hi-MS define anti-1,6-HD index (AICAP) quantify 1,6-HD sensitivity under physiological conditions....
Biomacromolecules form membraneless organelles through liquid-liquid phase separation in order to regulate the efficiency of particular biochemical reactions. Dysregulation might result pathological condensation or sequestration biomolecules, leading diseases. Thus, and separating factors may serve as drug targets for disease treatment. Nevertheless, such associations have not yet been integrated into related databases. Therefore, based on MloDisDB, a database organelle factor-disease...
Abstract Background Degrons are short linear motifs, bound by E3 ubiquitin ligase to target protein substrates be degraded the ubiquitin-proteasome system. Mutations leading deregulation of degron functionality disrupt control abundance due mistargeting proteins destined for degradation and often result in pathologies. Targeting degrons small molecules also emerges as an exciting drug design strategy upregulate expression specific proteins. Despite their essential function disease...
Macrophage-mediated inflammation is closely linked to the pathogenesis of acute kidney injury (AKI) and shift macrophages a pro-inflammatory phenotype being reliant on glycolytic metabolism. Galloflavin, polyphenol derived from tea, functions as lactate dehydrogenase A (LDHA) inhibitor, effectively obstructing metabolic pathways. However, specific immunometabolic regulatory galloflavin in remain unclear. Here, we observed that drives alleviation metabolism levels lipopolysaccharide...
Abstract Antiphospholipid syndrome (APS) is a heterogeneous autoimmune disease with persistent antiphospholipid antibodies. This study aimed to identify unrecognized APS subgroups from multicenter cohorts ( n = 760, training: 415; validation: 345). Patients are stratified through unsupervised K‐means clustering analysis. Prognostic outcomes evaluated using Kaplan‐Meier survival analyses. Proteomic analysis conducted on primary patients 36) and healthy controls 12). Key molecule insulin‐like...
Submicron-sized poly(N-isopropyl acrylamide)/polyethyleneimine core-shell microgels were prepared in aqueous media by using tert-butyl hydroperoxide (TBHP) as an initiator, and then the gold nanoparticles (∼8 nm) formed on surface of microgels. The amino groups polyethyleneimine (PEI) chains act binder for assembly nanoparticles/microgel complex. In are highly stable with their extended PEI chains, this multi-scale nanoparticle complex can be recovered from water redispersed water....
The study was aimed at investigating the effects of walnut oligopeptides (WOPs) on alcohol-induced acute liver injury and its underlying mechanisms. Male Sprague Dawley (SD) rats were randomly assigned to six groups: normal control, alcohol whey protein (440 mg/kg.bw), three WOPs (220 mg/kg.bw, 440 880 mg/kg.bw) groups. After 30 days gavage, ethanol with a volume fraction 50%, administered dose 7 g/kg.bw., caused injury. A righting reflex experiment blood concentration evaluation then...
The study was aimed to determine whether treatment with oat oligopeptides (OOPs) could modulate hyperglycemia related type 2 diabetes mellitus (T2DM) in Sprague–Dawley (SD) rats. Diabetic SD rats modeling by a joint effect of high-calorie diet for 45 days and twice intraperitoneal injection 30 mg/kg streptozotocin at one-week interval were observed or without OOPs administration (0.25, 0.50, 1.00, 2.00 g/kg Body Weight) 12 weeks. Fasting blood glucose (FBG), oral test tolerance (OGTT), serum...
The low photoluminescence (PL) quantum yields of transition metal dichalcogenide monolayers have been a limiting factor for their optoelectronic applications. Various and even inconsistent mechanisms proposed to modulate PL efficiencies. Herein, we use PL/Raman microspectroscopy the corresponding in situ mapping, atomic force microscopy, field-effect transistor (FET) characterization investigate changes structural optical properties monolayer MoS2. Relatively power density (<4.08 × 105 W...
Nonalcoholic fatty liver disease (NAFLD) is a global health problem characterized by excessive accumulation of fat in the without effect other pathological factors including hepatitis infection and alcohol abuse. Current studies indicate that gene play important roles development NAFLD. However, molecular characteristics differentially expressed genes (DEGs) associated mechanisms with NAFLD have not been well elucidated. Using two microarray data expression profiling tissues mice models, we...
Abstract Cells are compartmentalized by numerous membrane-bounded organelles and membraneless (MLOs) to ensure temporal spatial regulation of various biological processes. A number MLOs, such as nucleoli, nuclear speckles stress granules, exist liquid droplets within the cells arise from condensation proteins RNAs via liquid–liquid phase separation (LLPS). By concentrating certain RNAs, MLOs accelerate biochemical reactions protect during stress, dysfunction is associated with pathological...
Abstract Proteins perform their functions by folding amino acid sequences into dynamic structural ensembles. Despite the important role of protein dynamics, complexity and absence efficient representation methods have limited integration studies on function mutation fitness, especially in deep learning applications. To address this, we present SeqDance, a language model designed to learn properties directly from sequence alone. SeqDance is pre-trained biophysical derived over 30,400...
Abstract Disrupted protein phosphorylation due to genetic variation is a widespread phenomenon that triggers oncogenic transformation of healthy cells. However, few relevant disruption events have been verified limited biological experimental methods. Because the lack reliable benchmark datasets, current bioinformatics methods primarily use sequence-based traits study variant impact on (VIP). Here, we increased number experimentally supported VIP from less than 30 740 by manually curating...
Dietary intervention is crucial for the prevention and control of diabetes. China has largest diabetic population in world, yet no one dietary strategy matches eating habits Chinese people. To explore an effective acceptable pattern, this study uses oat buckwheat compound (OBC) as a staple food substitute explored its effects on Sprague-Dawley rats. The model rats was established by combining high-calorie feed streptozotocin (STZ) injection. seven groups, including normal group, metformin...
The study aimed to investigate the serum antigenomic profiling in rheumatoid arthritis (RA) and determine potential diagnostic biomarkers using label-free proteomic technology implemented with machine-learning algorithm.
Abstract Biomacromolecules form membraneless organelles through liquid–liquid phase separation in order to regulate the efficiency of particular biochemical reactions. Dysregulation might result pathological condensation or sequestration biomolecules, leading diseases. Thus, and separating factors may serve as drug targets for disease treatment. Nevertheless, such associations have not yet been integrated into related databases. Therefore, based on MloDisDB, a database organelle...
Nutritional intervention is a basic way to prevent and treat diabetes mellitus. Appropriate whole grain intake daily recommended. The study aimed explore the feasibility of kind buckwheat-oat-pea composite flour (BOP, quality ratio buckwheat:oats:peas = 6:1:1) as stable food substitution its underlying mechanisms. High-fat (HFD) streptozotocin injection were used induce in rats, buckwheat, oats, three different doses BOP added HFD separately for diet intervention. lasted 10 weeks, glucose...