The study investigated the protective effect of walnut oligopeptides (WOPs) against ethanol-induced gastric injury using Sprague-Dawley (SD) rats. Rats were randomly divided into seven groups based on body weight (10/group), normal group, ethanol whey protein group (220 mg/kg weight), omeprazole (20 and three WOPs (220, 440, 880 weight). After 30 days treatment with WOPs, rats given 5 mL/kg absolute by gavage to induce mucosal injury. Gastric ulcer index (GUI) determined following measured;...

This study aimed to investigate the immunomodulatory effects of walnut (Juglans regia L.) oligopeptides (WOPs). Female BALB/c mice were randomly assigned control, whey protein control and three WOPs groups, given deionized water, 220 mg/kg BW protein, 110, 440 daily through drinking water for 30 days, respectively. The immonomodulatory activity determination involved innate adaptive immunity, spleen T lymphocyte subpopulations, serum cytokine immunoglobulin levels. Our results showed that...

The aim of this study was to investigate the potential protective effects walnut oligopeptides (WOPs) on indomethacin-induced gastric ulcers in rats. rats were divided into following groups: normal group, model omeprazole group (0.02 g/kg), and WOPs groups (0.22, 0.44, 0.88 g/kg, respectively). After receiving gavage once per day for 30 consecutive days, injected intraperitoneally with indomethacin 48 mg/kg induce ulcers. Then, serum inflammatory cytokines prostaglandin E2 (PGE2), oxidative...

Walnut oligopeptides (WOPs) intake is associated with the augment of antioxidant defense system and immune system. The chief object this study to evaluate radioprotective effect walnut extracted from seed protein against 60Coγ-irradiation induced damage in mice. Female BALB/c mice were administered WOPs through drinking water for 14 days until a single dose whole-body 60Coγ-irradiation. 30-day survival test was carried out first group (8 Gy), other two groups (3.5 Gy) sacrificed at 3...

The study was aimed at investigating the effects of walnut oligopeptides (WOPs) on alcohol-induced acute liver injury and its underlying mechanisms. Male Sprague Dawley (SD) rats were randomly assigned to six groups: normal control, alcohol whey protein (440 mg/kg.bw), three WOPs (220 mg/kg.bw, 440 880 mg/kg.bw) groups. After 30 days gavage, ethanol with a volume fraction 50%, administered dose 7 g/kg.bw., caused injury. A righting reflex experiment blood concentration evaluation then...

The aim of this study was to clarify the anti-fatigue effect peanut oligopeptides (POPs) in mice and investigate its possible underlying mechanism. A total 150 male ICR were randomly assigned into five groups: control, whey protein (0.50 g/kg·bw), three peptide groups (0.25, 0.50, 1.00 g/kg·bw). All treated with intra-gastric administration for 30 days. Following intervention, a weight-loaded swimming test, blood lactate concentration, glycogen content, activities antioxidant factors energy...

Peptic ulcer has a serious impact on people’s health around the world, and traditional medicines can cause adverse reactions. This study investigated protective effects of tilapia collagen oligopeptides (TCOPs) gastroduodenal injury. Seventy-two specific pathogen-free (SPF) male Sprague Dawley (SD) rats were randomly divided into six groups according to body weight: normal control group, ethanol whey protein group (500 mg/kg BW), three TCOPs dose (250, 500, 1000 BW). After intragastric...

The current study sought to investigate the effect of nimotuzumab combined with concurrent chemoradiotherapy (CCRT + Nim) on T lymphocyte subsets in middle-advanced CC. Firstly, patients CC were administered CCRT or Nim. Next, levels lymphocytes peripheral blood pre- post-treatment and healthy females determined by flow cytometry. short-term efficacy was evaluated, overall survival (OS) progression-free (PFS) recorded. In addition, correlation OS/PFS assessed Pearson analysis. exhibited...

Osteoarthritis (OA) has been scarcely researched among patients with diabetes mellitus. This study aims to confirm the preventive and therapeutic effects of undenatured type II collagen (UC II) on OA in aging db/db mice T2DM. Firstly, were randomly assigned three groups: UC intervention group, old model (OM) group positive control group. Meanwhile db/m young used as normal groups, respectively. Secondly, fifty-five T2DM diagnosed knee two UC-II placebo groups. After a three-month both...

Aging-related muscle loss is a hallmark of aging and the cause some negative outcomes. An optimized diet supplements have positive effect in slowing down process loss. This study was designed to evaluate beneficial effects walnut oligopeptides (WOPs) on aging-related explore possible underlying mechanism Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice. SAMP8 mice were randomly divided into four groups (n = 15/group), including one group which age control three those WOP intervention...

Radiation therapy is widely used in the treatment of tumor diseases, but it can also cause serious damage to body, so necessary find effective nutritional supplements. The main purpose this study evaluate protective effect whey hydrolysate peptides (WHPs) against 60Coγ radiation mice and explore mechanism. BALB/c were given WHPs by oral gavage administration for 14 days. Then, some underwent a 30-day survival test after 8 Gy radiation, other received 3.5 analyze changes body weight,...

Aging-related learning and memory decline are hallmarks of aging pose a significant health burden. The effects walnut oligopeptides (WOPs) on were evaluated in this study. Sixty SAMP8 mice randomly divided into four groups (15 mice/group), including one age-control group three WOP-treated groups. SAMR1 (n = 15) that show normal senescence rate used as controls. controls administered ordinary sterilized water, while the WOP-intervention 110, 220, 440 mg/kg·bw WOPs respectively. whole...

This study aimed to observe the immunomodulatory effects of oligopeptides derived from jackfruit (<italic>Artocarpus heterophyllus</italic> Lam.) (JOPs).

Ageing-related bone impairment due to exposure hyperglycemic environment is scarcely researched. The aim was confirm the improvement effects of undenatured type II collagen (UC II) on in ageing db/db mice, and model established by normal feeding for 48-week-old. Then, mice were randomly assigned UC intervention, model, chondroitin sulfate + glucosamine hydrochloride control groups. After 12 weeks treatment, femoral microarchitecture biomechanical parameters observed, biomarkers including...

Walnut Oligopeptides (WOPs), the effective component of walnut, has been reported to have a neuron protective effect, but preventive effect on Alzheimer's disease (AD) related memory loss and underlying mechanisms not well determined. The senescence-accelerated mouse (SAM) is useful model AD-related impairment. In present study, SAMP8 mice aged 4 months were chronically treated with ginsenoside (3 dose groups given WOPs in diet for 6 months). three 110, 220 440 mg/kg · bw per day,...

Objective To investigate the clinical prediction value of chemokine CCL21 level for acute coronary syndrome. Methods Totally 212 patients receiving arteriography were divided into myocardial infarction group(AMI, n=72), unstable angina pectoris group(UAP, n=76), and stable group(SAP, n=64). The serum was detected by double-antibody sandwich enzyme-linked immunosorbent assay(ELISA)and pathological changes artery measured Gensini scoring system.All followed up six months cardiovascular...