A5077454047- Spine and Intervertebral Disc Pathology
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Knee injuries and reconstruction techniques
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Orthopedic Infections and Treatments
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Medical Imaging Techniques and Applications
- Shoulder Injury and Treatment
- Scoliosis diagnosis and treatment
- Anatomy and Medical Technology
- Lower Extremity Biomechanics and Pathologies
- AI in cancer detection
- Retinal Imaging and Analysis
- Advanced Neural Network Applications
- Radioactive element chemistry and processing
- Retinal Diseases and Treatments
- Medical Image Segmentation Techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Pelvic and Acetabular Injuries
- Cholesterol and Lipid Metabolism
Northwestern University
2023-2024
Northwestern Medicine
2024
Newton Wellesley Hospital
2019-2024
Neurological Surgery
2024
Shenzhen Second People's Hospital
2022-2024
University of South China
2022-2023
Harvard University
2019-2022
Massachusetts General Hospital
1995-2022
Binghamton University
2016-2020
Zunyi Medical University
2018
Crocin (CRO), chlorogenic acid (CGA), geniposide (GEN), and quercetin (QUE) are all natural compounds with anti-obesity properties, in particular, hypolipidemic effects, which have been widely used for the treatment of obesity-related metabolic diseases. However, it is not yet known whether these interact synergistically. Here, we investigated effects molecular mechanisms CRO, CGA, GEN, QUE, a combination four (CCGQ), on lipid accumulation human hepatoma (HepG2 cells).The optimal...
<abstract> <p>Medical image segmentation of the liver is an important prerequisite for clinical diagnosis and evaluation cancer. For automatic from Computed Tomography (CT) images, we proposed a Multi-scale Feature Extraction Enhancement U-Net (mfeeU-Net), incorporating Res2Net blocks, Squeeze-and-Excitation (SE) Edge Attention (EA) blocks. The blocks which are conducive to extracting multi-scale features were used as backbone encoder, while SE also added encoder enhance channel...
Catheter Digital Subtraction Angiography (DSA) is markedly degraded by all voluntary, respiratory, or cardiac motion artifact that occurs during the exam acquisition. Prior efforts directed toward improving DSA images with machine learning have focused on extracting vessels from individual, isolated 2D angiographic frames. In this work, we introduce improved + t deep models leverage rich temporal information in timeseries. A total of 516 cerebral angiograms were collected 8784 individual...
Abstract Purpose Numerous research has reported that total knee arthroplasty (TKA) cannot reproduce axial tibial rotations of normal knees. The objective this study was to measure the tibiofemoral articular contact motions and TKA knees investigate mechanism causing kinematics change after TKAs. Methods Eleven patients with unilateral cruciate retaining (CR) were tested for measurements motion during a weight-bearing flexion from 0° 105° using an imaging technique. determined points on...
Prediction of the biomechanical effects fusion surgery on adjacent segments is a challenge in computational biomechanics spine. In this study, two-segment L3-L4-L5 model was developed to simulate spinal segment responses under follower load condition. The interaction between degenerative (L4-5) and (L3-4) simulated using an equivalent spring. spring stiffness calibrated rigid completely degenerated disc at L4-5 level, resulting upper bound response segment. obtained used with different...
Fe 3 O 4 @SiO 2 @UiO-66 exhibits excellent adsorption capacity of uranium( vi ) and easy separation.
Soft tissues observed in clinical medical images are often prestrained tension by internal pressure or tissue hydration. For a native disc, nucleus swelling occurs equilibrium with osmotic induced the high concentration of proteoglycan nucleus. The objective this computational study was to investigate effects on disc geometry, fiber orientation, and mechanical behavior comparing those zero-pressure (unswelled) discs. Thermoelastic analysis techniques were repurposed order determine geometry...
Mechanical thrombectomy has become the standard of care for acute ischemic stroke due to large vessel occlusions. Racial differences in outcomes after mechanical have not been extensively studied. We evaluate real-world evidence between races occlusions using NeuroVascular Quality Initiative-Quality Outcomes Database (NVQI-QOD).
Using large femoral heads in total hip arthroplasty (THA) has been widely advocated to improve the function and longevity of components. However, increasing head size shown accelerate polyethylene liner wear. Few studies have investigated effect other important structural parameters (such as thickness, metal cup size, head-liner conformity, loading conditions, etc.) on biomechanical functions THAs. In this study, an analytical model was used evaluate wear characteristics THAs (defined using...
Leucine-rich α2-glycoprotein-1 (LRG1) is overexpressed in various cancers, including non-small cell lung cancer (NSCLC), but its role NSCLC metastasis not well understood. In this study, exosomes were analyzed using different techniques, and the impact of exosomal LRG1 on behavior was investigated through assays both vitro vivo. The study revealed that LRG1, found abundantly cells exosomes, enhanced proliferation, migration, invasion, epithelial-mesenchymal transition (EMT). Exosomal shown...
Accurate segmentation of liver tumor regions in medical images is great significance for clinical diagnosis and the planning surgical treatments. Recent advancements machine learning have shown that convolutional neural networks are powerful such image processing while largely reducing human labor. However, variable shape, fuzzy boundary, discontinuous region tumors bring challenges to accurate segmentation. The feature extraction capability a network can be improved by expanding its...
Abstract Total disk arthroplasty (TDA) using an artificial (AD) is attractive surgical technique for the treatment of spinal disorders, since it can maintain or restore motion (unlike interbody fusion). However, adverse outcomes contemporary lumbar TDAs have been reported. We previously proposed a new mobile-bearing AD design concept featuring biconcave ultrahigh-molecular-weight polyethylene (UHMWPE) mobile core. The objective this study was to develop neural network (NN) based...
Accurate biomechanical investigation of human intervertebral discs (IVDs) is difficult because their complicated structural and material features.To investigate probabilistic distributions the responses IVD by considering varying nonlinear properties using a stochastic finite element (FE) model.A FE model L3-4 disc was reconstructed, including nucleus pulposus (NP), annular matrix fibers. A Monte Carlo method used to randomly generate 500 sets fiber orientations that were implemented into...
(2020). Sensitivities of lumbar segmental kinematics and functional tissue loads in sagittal bending to design parameters a ball-in-socket total disc arthroplasty prosthesis. Computer Methods Biomechanics Biomedical Engineering: Vol. 23, No. 9, pp. 536-547.