A5035325211- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- MRI in cancer diagnosis
- Cerebral Venous Sinus Thrombosis
- Meningioma and schwannoma management
- Spinal Fractures and Fixation Techniques
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Medical Imaging and Analysis
- Neurosurgical Procedures and Complications
- Moyamoya disease diagnosis and treatment
- Advanced Neuroimaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Vascular Procedures and Complications
- Medical Imaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Vascular Anomalies and Treatments
- Bone Tumor Diagnosis and Treatments
Northwestern University
2016-2025
Neurological Surgery
2016-2025
Northwestern Medicine
2021-2025
Assam Down Town University
2024-2025
King Hamad University Hospital
2023-2024
Lurie Children's Hospital
2013-2024
Cleveland Clinic
2023
Northwestern Memorial Hospital
2016-2022
University of Iowa
2020
Government Medical College
2016-2019
Thrombectomy is currently recommended for eligible patients with stroke who are treated within 6 hours after the onset of symptoms.We conducted a multicenter, randomized, open-label trial, blinded outcome assessment, thrombectomy in to 16 they were last known be well and had remaining ischemic brain tissue that was not yet infarcted. Patients proximal middle-cerebral-artery or internal-carotid-artery occlusion, an initial infarct size less than 70 ml, ratio volume on perfusion imaging 1.8...
Table 1 Randomized trials and registries of modern approaches to thrombectomy Trial no patients, total/Ia (when applicable) lVo location Time window for thrombectomy, hours Stroke severity (nIhSS score) Imaging criteria Treatment groups mrS score=0-2 at 90 days trials: Endovascular vs medical MR CLEAN 8 500/223 ICA, M1, M2, A1, A2 0-6 ≥2 No limit arm: stent retrievers in 97% IA cases, 87% IA-treated patients received IV rtPA first.Control 91% group: 33% Control 19% NNT=7.1 ESCAPE 13 215/165...
Objective To summarize the current literature regarding initial hospital management of patients with acute ischemic stroke (AIS) secondary to emergent large vessel occlusion (ELVO), and offer recommendations designed decrease time endovascular treatment (EVT) for appropriately selected stroke. Methods Using guidelines evidenced-based medicine proposed by Stroke Council American Heart Association, a critical review all available medical supporting best AIS ELVO was performed. The purpose...
Cerebral and cardiac blood flow are important to the pathophysiology development of cerebro- cardiovascular diseases. The purpose this study was investigate age dependence normal cerebral hemodynamics in children adults over a broad range ages.
To improve velocity-to-noise ratio (VNR) and dynamic velocity range of 4D flow magnetic resonance imaging (MRI) by using dual-velocity encoding (dual-venc) with k-t generalized autocalibrating partially parallel acquisition (GRAPPA) acceleration.A dual-venc MRI sequence GRAPPA acceleration was developed a shared reference scan followed three-directional low- high-venc scans (repetition time / echo flip angle = 6.1 msec 3.4 15°, temporal/spatial resolution 43.0 msec/1.2 × 1.2 mm3 ). The data...
Stenosis of major intracranial arteries is a significant cause stroke, with assessment trans-stenotic pressure drops being key marker functional stenosis severity. Non-invasive methods for quantifying changes are hence crucial; however, the narrow and tortuous cerebrovascular network poses challenges to traditional such as transcranial Doppler. This study investigates use novel deep learning-enhanced super-resolution (SR) four-dimensional (4D) flow magnetic resonance imaging (MRI) in...
Background and Purpose— The durability of aneurysm coil embolization is thought to depend on packing density. expansile property hydrogel coating coils increases volumetric per length. We describe our experience using hydrogel-coated (HydroCoils) compared with inert platinum in intracranial embolization. Methods— Fifty aneurysms embolized primarily HydroCoils from 2003 2004 were 57 volume- shape-matched treated standard 2000 2003. Outcome measures included percentage occlusion (VPO), length...
<h3>BACKGROUND AND PURPOSE:</h3> Arteriovenous malformations are an important etiology of hemorrhagic stroke. However, current imaging modalities and risk do not provide insights into individual AVM hemodynamics its role in pathophysiology. The aims this study to determine whether intracranial 4D flow MR can arteriovenous malformation independent the Spetzler-Martin grade report changes observed during staged embolization. <h3>MATERIALS METHODS:</h3> Intracranial 3D blood was assessed 20...
Purpose To use four‐dimensional (4D)‐flow MRI for the comprehensive in vivo analysis of hemodynamics and its relationship to size morphology different intracranial aneurysms (IA). We hypothesize that IA groups, defined by morphology, exhibit velocity fields, wall shear stress, vorticity. Materials Methods The 4D‐flow (spatial resolution = 0.99–1.8 × 0.78–1.46 1.2–1.4 mm 3 , temporal 44–48 ms) was performed 19 IAs (18 patients, age 55.4 ± 13.8 years) with saccular (n 16) fusiform 3) sizes...
Recent randomized clinical trials1–5 established the superiority of endovascular recanalization techniques, specifically mechanical embolectomy, compared with best medical therapy alone for treatment patients emergent large vessel occlusion (ELVO) stroke. ELVO stroke is defined as a secondary to anterior circulation (LVO) internal carotid, middle cerebral (M1 segments) arteries documented by imaging, without completed infarct and presenting within 6 hours symptom onset.6 Given overwhelming...
The Solitaire stent retriever registry showed improved reperfusion, faster procedure times, and better outcome in acute stroke patients with large vessel occlusion treated a balloon guide catheter (BGC) compared conventional catheter. goal of this study was to evaluate whether use BGC the Trevo improves outcomes catheter.The TRACK recruited 23 sites submit demographic, clinical, site adjudicated angiographic data on consecutive retriever. at discretion physician.536 anterior circulation (of...
Mechanical thrombectomy (MT) is the standard-of-care treatment for stroke patients with emergent large vessel occlusions. Despite this, little known about physician decision making regarding MT and prognostic accuracy.A prospective multicenter cohort study of undergoing was performed at 11 comprehensive centers. The attending neurointerventionalist completed a preprocedure survey prior to arterial access identified key factors most likely radiographic clinical outcome 90 days. Post hoc...
In this study, we evaluated the use of a part-task simulator with 3-dimensional and haptic feedback as training tool for percutaneous spinal needle placement.To evaluate learning effectiveness in terms entry point/target point accuracy placement on high-performance augmented-reality technology workstation ability to control duration computer-simulated fluoroscopic exposure, thereby simulating an actual situation.Sixty-three fellows residents performed simulator. A virtual was percutaneously...
Since the SAMMPRIS trial (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis), aggressive medical management (AMM), which includes dual antiplatelet therapy (DAPT) high-dose statin (HDS) therapy, is recommended patients with symptomatic intracranial atherosclerotic disease. However, limited data on real-world application of this regimen exist. We hypothesized that recurrent stroke risk among treated AMM similar to arm cohort.
The authors undertook this study to assess the safety and efficacy of Onyx embolization in treatment intracranial arteriovenous malformations (AVMs) pediatric patients.All AVM cases performed consecutively at a single children's hospital over 5-year period were collected evaluated.Twenty-five patients (mean age 10.5 years) underwent total 38 procedures. An aggregate 56 pedicles embolized 1.47 per session). Spetzler-Martin grade was determined all cases. resulted complete obliteration 3 (12%)...
<h3>BACKGROUND AND PURPOSE:</h3> Contrast enhancement of intracranial atherosclerotic plaques has recently been investigated using high field and resolution MR imaging as a risk factor in the development ischemic stroke. We studied reliability conventional at 1.5T evaluating intraplaque its relationship with acute cerebrovascular presentations patients severe disease. <h3>MATERIALS METHODS:</h3> retrospectively identified analyzed 19 22 high-grade disease (>70% stenosis) vessels...