A5078439021- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Neurosurgical Procedures and Complications
- Radiation Dose and Imaging
- Cell Adhesion Molecules Research
- Neurological Disorders and Treatments
- Medical Imaging and Analysis
- S100 Proteins and Annexins
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Organ Donation and Transplantation
- Blood Pressure and Hypertension Studies
- Advanced MRI Techniques and Applications
- Blood Coagulation and Thrombosis Mechanisms
- Erythropoietin and Anemia Treatment
Mercy Health
2022
University of Kansas
2022
SUNY Upstate Medical University
2013-2022
Medical University of South Carolina
2022
University of Alabama at Birmingham
2019-2021
Northwestern University
2015-2018
Northwestern Memorial Hospital
2015-2017
Neurological Surgery
2017
Northwestern Medicine
2014-2015
<h3>Background and Objectives</h3> To review treatments for reducing the risk of recurrent stroke or death in patients with symptomatic intracranial atherosclerotic arterial stenosis (sICAS). <h3>Methods</h3> The development this practice advisory followed process outlined American Academy Neurology <i>Clinical Practice Guideline Process Manual, 2011 Edition,</i> as amended. systematic included studies through November 2020. Recommendations were based on evidence, related principles care,...
<h3>Objective:</h3> We investigated health-related quality of life (HRQOL) in patients with TIA and minor ischemic stroke (MIS) using Neuro-QOL, a validated, patient-reported outcome measurement system. <h3>Methods:</h3> Consecutive or MIS who had (1) modified Rankin Scale (mRS) score 0 1 at baseline, (2) initial NIH Stroke ≤5, (3) no acute reperfusion treatment, (4) 3-month follow-up, were recruited. Recurrent stroke, disability by mRS Barthel Index, Neuro-QOL scores 5 prespecified domains...
Since the SAMMPRIS trial (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis), aggressive medical management (AMM), which includes dual antiplatelet therapy (DAPT) high-dose statin (HDS) therapy, is recommended patients with symptomatic intracranial atherosclerotic disease. However, limited data on real-world application of this regimen exist. We hypothesized that recurrent stroke risk among treated AMM similar to arm cohort.
<h3>Objective:</h3> We tested the hypothesis that admission serum magnesium levels are associated with hematoma volume, growth, and functional outcomes in patients intracerebral hemorrhage (ICH). <h3>Methods:</h3> Patients presenting spontaneous ICH were enrolled an observational cohort study prospectively collected demographic, clinical, laboratory, radiographic, outcome data. performed univariate adjusted multivariate analyses to assess for associations between initial final in-hospital...
Background and Purpose: While prior studies identified risk factors for recurrent stroke in patients with symptomatic intracranial atherosclerotic disease, few have assessed early infarct recurrence. Methods: We performed a post hoc analysis of the MYRIAD study (Mechanisms Early Recurrence Intracranial Atherosclerotic Disease) disease recent (<21 days) stroke/transient ischemic attack, 50% to 99% stenosis who underwent 6- 8-week magnetic resonance imaging (MRI) per protocol. Infarct...
<b><i>Background:</i></b> Prognostic assessments, which are crucial for decision-making in critical illnesses, have shown unsatisfactory reliability. We compared the accuracy of a widely used prognostic score against model derived from clinical data obtained 5 days after admission patients with intracerebral hemorrhage (ICH), condition prognostication has proven notoriously challenging and prone to bias. <b><i>Methods:</i></b> Patients enrolled...
Background A carotid web can be defined as an endoluminal shelf-like projection often noted at the origin of internal artery (ICA) just beyond bifurcation. Diagnosis a underlying cause recurrent ischemic stroke is infrequent and easily misdiagnosed atheromatous plaque. Surgery has traditionally been used to resect symptomatic lesions while there no enough evidence supporting medical therapy sole management. To our knowledge only one report about stenting (CAS) definite management previous...
Objectives: We sought to determine the effect of acute electrolyte and osmolar shifts on brain volume neurologic function in patients with liver failure severe hepatic encephalopathy. Design: Retrospective analysis CT scans clinical data. Setting: Tertiary care hospital ICUs. Patients: Patients or acute-on-chronic Interventions: Clinically indicated serum laboratory studies. Measurements Main Results: Change intracranial cerebrospinal fluid between sequential was measured as a biomarker...
Background In patients with mild ischemic stroke, small but eloquent infarcts may have devastating effects, particularly on health-related quality of life. Aim This study investigates the association between acute infarct location and three-month life in stroke. Methods We evaluated consecutively enrolled from a single center August 2012 July 2013. Our primary outcome at three months was impairment any domain (upper extremity, lower executive function, general concerns) defined by T-score...
Introduction: While much is known about recurrent clinical events in patients with intracranial atherosclerotic disease (ICAD), there limited data on characteristics of infarcts. Methods: The NIH-funded MyRIAD prospective, observational study was designed to identify mechanisms ischemia and predictors recurrence ICAD. Recurrent infarction assessed MRI at 6–8 weeks. We reviewed the DWI/ADC FLAIR sequences stroke characterized number infarcts, infarct location, size, patterns based whether...
Introduction: Despite aggressive medical management, patients with symptomatic intracranial atherosclerotic disease (ICAD) remain at high risk for recurrent stroke. There are no reliable biomarkers to identify those highest and in whom flow restorative procedures may be warranted. We hypothesized that a borderzone infarct pattern would predict 90-day stroke the territory of ICAD. Methods: Using prospective registry single center, we identified consecutive admitted between 2012 2017 confirmed...
Introduction: Prior studies have evaluated risks factors for recurrent stroke in patients with symptomatic intracranial atherosclerotic disease (ICAD). However, few reports assessed risk early infarct recurrence the territory distal to artery. Methods: We analyzed data from who underwent study-paid brain MRI at 6-8 weeks after enrollment ongoing MyRIAD study, an NIH/NINDS funded prospective multicenter observational study of recent ( < 21 days) or TIA (recurrent DWI) caused by ICAD 50-99%...
OBJECTIVE: A comparison of Neuro-QOL: cognitive health domains with mRS in acute ischemic stroke BACKGROUND: The modified Rankin scale (mRS) is a reliable objective measure disability which has been widely applied clinical trials. Health-related quality life (QOL) measurements using Neuro-QOL acts as continuous measurement function from the patient perspective and provides validated measures patient- reported outcomes. We compared QOL scores at 3 months after stroke or transient attack...
Introduction: The modified Rankin scale (mRS) is a reliable objective measure of disability and widely applied in clinical trials. Health-related quality life (QOL) measurements using Neuro-QOL provide validated measures patient-reported outcomes. We compared changes physical function QOL scores with transitions mRS after ischemic stroke or transient attack (TIA). Methods: From single-center prospective cohort study, we identified TIA patients admitted between August 2012 April 2013 who...
Background: Since the SAMMPRIS trial, aggressive medical management (AMM) with use of dual antiplatelets (aspirin, clopidogrel) and high dose statin therapy has been standard care for patients symptomatic intracranial atherosclerotic disease (ICAD). However, there is limited data on “real-world” application this regimen. We hypothesized that 30-day recurrent stroke risk among treated AMM would be similar to in medically-treated patients. Methods: Using prospective Northwestern University...
Objective:We hypothesized that 30-day and 90-day recurrent stroke risk among patients treated with AMM would be similar to SAMMPRIS medically-treated (5.8[percnt] at 30 days 8.6[percnt] 90 days). Background:The trial included aggressive medical management (AMM) composed of dual antiplatelets (aspirin, clopidogrel), high dose statin therapy lifestyle changes (exercise diet modification), becoming the ideal treatment for symptomatic intracranial atherosclerotic disease (ICAD). However, there...
Introduction: Neuro-QOL was developed to provide researchers with a continuous, validated, patient-reported measurement of quality life. Previous studies suggest that minor ischemic stroke (MIS) can lead disability and impaired life in substantial proportion patients. We hypothesized infarct location predicts 3-month QOL patients MIS. Methods: identified MIS (NIHSS ≤ 5) confirmed acute infarcts on DWI, admitted between August 2012 July 2013, who underwent outcomes assessments at 3 months....
Introduction: The modified Rankin scale (mRS) is a reliable objective measure of disability and widely applied in clinical trials. Health-related quality life (QOL) measurements using Neuro-QOL provide validated measures patient-reported outcomes. In matched case-control study, we hypothesized that differences QOL favor tPA would be readily detectable compared to the dichotomous mRS outcome traditionally acute stroke research. Methods: From single-center prospective cohort identified...