A5041026092- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Fire dynamics and safety research
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- Combustion and flame dynamics
- Combustion and Detonation Processes
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Valve Diseases and Treatments
- Acute Ischemic Stroke Management
- Heat Transfer and Optimization
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Adsorption and Cooling Systems
- Atomic and Subatomic Physics Research
- Solar-Powered Water Purification Methods
- MRI in cancer diagnosis
- Trigeminal Neuralgia and Treatments
- Fire Detection and Safety Systems
- Advanced X-ray Imaging Techniques
- Environmental and Industrial Safety
- Model Reduction and Neural Networks
Northwestern University
2017-2020
University of Alberta
2012-2016
Medical College of Wisconsin
2016
University of Saskatchewan
2009
Purpose To evaluate the accuracy and feasibility of a free‐breathing 4D flow technique using compressed sensing (CS), where imaging thoracic aorta is performed in 2 min with inline image reconstruction on MRI scanner less than 5 min. Methods The 10 vitro scans were different acceleration rates pulsatile phantom (9 CS factors [R = 5.4–14.1], 1 generalized autocalibrating partially parallel acquisition [GRAPPA] R 2). Based results, CS‐accelerated was acquired 20 healthy volunteers (38.3 ± 15.2...
Purpose This study evaluated the feasibility of using 4D flow MRI and a semi‐automated analysis tool to assess hemodynamic impact intracranial atherosclerotic disease (ICAD). The ICAD was investigated by evaluating pressure drop (PD) at stenosis changes in cerebral blood distribution patients compared healthy controls. Methods Dual‐venc acquired 25 volunteers 16 (ICA, N = 3; MCA, 13) with mild (<50%), moderate (50–69%), or severe (>70%) stenosis. A developed quantify velocity from...
Background Cerebral arteriovenous malformations (AVMs) are pathological connections between arteries and veins. Dual‐ venc 4D flow MRI, an extended MRI method with improved velocity dynamic range, provides time‐resolved 3D cerebral hemodynamics. Purpose To optimize dual‐ imaging parameters for AVM; to assess the relationship spatial resolution, acceleration, quantification accuracy; introduce apply distribution network graph (FDNG) paradigm storing analyzing complex neurovascular data. Study...
Background Systematic evaluation of complex flow in the true lumen and false (TL, FL) is needed to better understand which patients with chronic descending aortic dissection (DAD) are predisposed complications. Purpose To develop quantitative hemodynamic maps from 4D MRI for evaluating TL FL characteristics. Study Type Retrospective. Population In all, 20 DAD (age = 60 ± 11 years; 12 male) (six medically managed type B AD [TBAD], 14 repaired A [rTAAD] now ascending graft [AAo] or elephant...
Background Stroke etiology is undetermined in approximately one‐sixth to one‐third of patients. The presence aortic flow reversal and plaques the descending aorta (DAo) has been identified as a potential retrograde embolic mechanism. Purpose To assess relationships between stiffness, wall thickness, patients with cryptogenic stroke healthy controls. Study Type Prospective. Population Twenty one proven DAo (69 ± 9 years, 43% female), 18 age‐matched controls (age: 65 8 61% 14 younger (36 57%...
Purpose To evaluate the utility of an efficient triple velocity‐encoding (VENC) 4D flow MRI implementation to improve velocity unwrapping data with same scan time as interleaved dual‐VENC acquisition. Methods A balanced 7‐point acquisition was used derive 3 sets images corresponding different VENCs. These datasets were then unwrap aliased lowest VENC into a minimally aliased, triple‐VENC dataset. Triple‐VENC evaluated and compared over ranges (50‐150, 60‐150, 60‐180 cm/s) in vitro steadily...
This study focuses on quantifying the effects of liquid-side boundary conditions burning characteristics a laboratory-scale methanol pool fire. Pool walls were constructed from copper, stainless steel, or quartz, and bottom temperature was altered 0°C to 50°C. Burning rate, flame height, wall liquid distributions measured. The rate increased with decrease in thermal conductivity. Significantly different vertical profiles fuel resulted materials. Wall heat fluxes estimated these measurements...
Purpose Simultaneous multislab (SMSb) 4D flow MRI was developed and implemented at 7T for accelerated acquisition of the 3D blood velocity vector field in both carotid bifurcations. Methods SMSb applied to acquire velocities bifurcations sagittal orientation using a local transmit/receive coil 7T. transmit efficiency optimized by shimming. obtained 8 healthy subjects single‐band (SB) multiband (MB) fashion. Additionally, MB data were retrospectively undersampled simulate GRAPPA R = 2...
To develop a reliable, consistent, and reproducible reference phantom for error quantification of phase-contrast MRI so it can be used validation quality control.An air-driven rotation consisting steadily rotating cylinder surrounded by static ring both filled with agarose gel was developed. Rotational speed measured controlled in real time using an optical counter closed-loop controller. Consistency the assessed recording variations rotational speed. The imaged 2D MRI, velocity at each...
In vivo measurements of intracranial pressure differences using 4D flow are useful to assess health risks associated with atherosclerotic disease (ICAD). the clinical routine, approximations Navier-Stokes equation used derive relative values, which can be inaccurate in vessels. Recently we presented an algorithm a virtual work-energy formulation(vWERP). While this technique yields more accurate estimations settings, still systematic errors due insufficient spatial resolution were observed....
Background Blood flow reversal is a possible mechanism for retrograde embolism in the setting of high‐risk atherosclerotic plaques descending aorta (DAo). Evidence suggests that pulse wave velocity (PWV) determinant blood and can be reduced by destiffening effect renin‐angiotensin system inhibitors (RASI). Purpose To evaluate impact antihypertensive therapy on vivo changes PWV patients with cryptogenic stroke. Study Type Prospective. Population Sixteen (69 ± 9 years; 10 males) included after...
Introduction: There is recent evidence that diastolic flow reversal in the descending thoracic aorta (DAo) prevalent patients with atherosclerosis, enabling a mechanism for cerebral embolism. Specifically, aortic stiffness (assessed by pulse wave velocity, PWV ) precursor of plaque formation and reverse . The aim this study was to 1) employ 4D MRI quantification both regional 2) evaluate relationships between PWV, age cohort cryptogenic stroke plaques DAo age-matched controls. Methods:...