Long-chain amidopropyl betaines are known for their ability to self-assemble into viscoelastic wormlike micellar structures. Here, we explore the effect of tailgroup molecular architecture on this process, comparing five molecules, each with C18 chains but different levels unsaturation and branching. The surfactants synthesized from stearic, oleic, linoleic, linolenic, isostearic acids. self-assembly these molecules in aqueous solutions is explored using small- ultra-small-angle neutron...

Hydration kinetics controls ‘bolus’ rheology and starch digestion of comminuted snack foods; <italic>in vitro</italic> provides new insights into oral processing food design.

Abstract Background Large vessel vasculitis (LVV) can be characterized based on symptom severity, and this characterization helps clinicians decide upon treatment approach. Our aim was to compare the imaging findings of combined modality positron emission tomography/magnetic resonance (PET/MR) inflammatory markers between severe non-severe LVV. A retrospective query performed identify all patients with LVV who underwent PET/MR at our institution January 2015 2021. Results Eleven (nine...

The spontaneous adsorption of graphene oxide (GO) sheets at the air-water interface is explored using X-ray reflectivity (XRR) measurements. As a pure aqueous dispersion, GO do not spontaneously adsorb due to their high negative surface potential (-60 mV) and hydrophilic functionality. However, when incorporated with surfactant molecules optimal ratios loadings, can be driven surface. It hypothesised that experience favourable attractive interactions surfaces sheets, resulting in co-assembly...

Background Pulmonary hypertension (PH) contributes to restricted flow through the pulmonary circulation characterized by elevated mean artery pressure acquired from invasive right heart catheterization (RHC). MRI may provide a noninvasive alternative for diagnosis and characterization of PH. Purpose To characterize PH via quantification regional transit times (rPTT). Study Type Retrospective. Population A total 43 patients (58% female); 24 controls (33% female). RHC‐confirmed classified as...

Cerebrovascular imaging assessments are particularly challenging in adolescent cohorts, where not all modalities appropriate, and rapid brain maturation alters hemodynamics at both macro- microvascular scales. In a preliminary sample of healthy adolescents (n=12, 8-25 years), we investigated relationships between 4D flow MRI-derived blood velocity bilateral anterior, middle, posterior cerebral arteries BOLD cerebrovascular reactivity associated vascular territories. As hypothesized, higher...

Introduction Intracranial 4D flow MRI enables quantitative assessment of hemodynamics in patients with intracranial atherosclerotic disease (ICAD). However, assessments are still challenging due to the time-consuming vessel segmentation, especially presence stenoses, which can often result user variability. To improve reproducibility and robustness as well accelerate data analysis, we developed an accurate, fully automated segmentation for stenosed vessels using deep learning. Methods 154...

Cerebrovascular dual-venc 4D flow MRI enables measurement of global and local intracranial 3D hemodynamics with full volumetric coverage the circle Willis. Hemodynamic analysis was completed using a semi-automated voxel-wise parametric mapping tool, enabling assessment velocity-based parameters, including mean velocity, peak kinetic energy time-to-peak velocity. The workflow reproducibility evaluated scan-rescan for 10 subjects who underwent two scans within 30 days. Global Willis...

Intracranial atherosclerotic disease (ICAD) accounts for 10-50% of acute ischemic strokes and is a leading cause global morbidity mortality. We used semi-automated voxel-wise velocity-based mapping approach to visualize quantify regional peak velocities (PVs) in the Circle Willis (CoW) 31 ICAD patients with moderate severe MCA or ICA stenosis 23 healthy controls. Our findings indicate 4D flow MRI-based cerebrovascular PV can detect asymmetric distribution CoW on hemispheric vessel levels....

In a preliminary sample of healthy adolescents, we evaluated the relationship between hemodynamic function in large cerebral arteries and smaller cortical vessels. Specifically, investigated correlations 4D flow MRI-derived systolic blood velocity anterior, middle, posterior BOLD cerebrovascular reactivity (CVR) associated vascular territories. Both amplitude delay CVR were negatively correlated with velocity. These results provide new insights into mechanism measures macrovascular flow, but...

In vivo measurements of intracranial pressure differences using 4D flow are useful to assess health risks associated with atherosclerotic disease (ICAD). the clinical routine, approximations Navier-Stokes equation used derive relative values, which can be inaccurate in vessels. Recently we presented an algorithm a virtual work-energy formulation(vWERP). While this technique yields more accurate estimations settings, still systematic errors due insufficient spatial resolution were observed....

Cerebrovascular imaging assessments are particularly challenging in adolescent cohorts, where not all modalities appropriate, and rapid brain maturation alters hemodynamics at both macro- microvascular scales. In a preliminary sample of healthy adolescents (n = 12, 8–25 years), we investigated relationships between 4D flow MRI-derived blood velocity bilateral anterior, middle, posterior cerebral arteries BOLD cerebrovascular reactivity (CVR) associated vascular territories. As hypothesized,...

Contrast Agent Arrival Time Maps for A Representative Control and PH Patient. All Eight Analysis Regions are Shown with RPTTS Relative to T0 from MPA (RPTT). Color Coding on Images Denotes CA in Seconds. Example RPTT Data Show Increased Between Patient Control. is 70 Year-Old-Female WHO Group 4 (MPAP = 29 MMHG, PCWP 9 PVR 5.7 WU). L R Denote Left Right, Respectively. SUP Superior; INF Inferior; PULM Pulmonary. BY Jackson E. Moore et al. (727-737).

Background Gadobutrol (GB) and gadoterate meglumine (GM) are contrast agents used for contrast‐enhanced magnetic resonance angiography (CEMRA). Supraaortic vasculature (SAV) CEMRAs to evaluate stroke risk neurologic symptoms. There is a need compare the SAV CEMRA image quality obtained with GB GM. Purpose To intra‐individually MRA images equimolar GM at 1.5 T in SAV. Study Type Prospective, crossover. Population Twenty‐eight subjects (54 ± 13 years; 17 female). Field Strength/Sequence ;...

Mechanisms underlying heart-brain hemodynamic coupling and effects on the brain remain unclear due to challenges of measuring both heart in a single MRI exam. We have developed comprehensive protocol that incorporates 1) 4D flow chest, 2) head 3) structural neuroimaging into one exam assess cardiovascular cerebrovascular as well white matter lesions atrophy. This study demonstrates utility viable new tool for vivo evaluation along entire pathway.

Cerebrovascular dual-venc 4D Flow MRI has utility in evaluating intracranial hemodynamics - benefitting from full circle of Willis (CoW) volumetric coverage, time-resolved, three-directional velocity encoding, and dynamic range. Analysis hemodynamic measures was completed using a comprehensive, semi-automated vessel identification segmentation workflow for 10 subjects who underwent two scans within 30 days. Test-retest analysis cerebrovascular CoW 3D flow dynamics demonstrated excellent...

Combined modality PET/MR may be a sensitive to detect severe large vessel vasculitis. To distinguish vasculitis, qualitative review of PET imaging findings appears more useful than standardized uptake values patient&amp;rsquo;s highest-uptake vessel. Inflammatory marker levels and trends, as well single-modality scan findings, were not significantly different between non-severe vasculitis patients.

Abstract Background Cardiovascular risk factors have been linked with dementia in aging adults. However, mechanisms underlying heart‐brain hemodynamic coupling and effects on the brain remain unclear. 4D flow MRI is uniquely poised to systematically evaluate complex hemodynamics along pathway. Owing advancements yielding shorter scan times, can be acquired approximately 7 minutes (heart) 10 (brain). This supports practical add‐on of neuroimaging scans for comprehensive evaluation under an...

Abstract Background Cardiovascular risk factors have been linked with dementia in aging adults. However, mechanisms underlying heart‐brain hemodynamic coupling and effects on the brain remain unclear. 4D flow MRI is uniquely poised to systematically evaluate complex hemodynamics along pathway. Owing advancements yielding shorter scan times, can be acquired approximately 7 minutes (heart) 10 (brain). This supports practical add‐on of neuroimaging scans for comprehensive evaluation under an...