A5100635689- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- Cancer-related gene regulation
- Genetic Syndromes and Imprinting
- Ferroptosis and cancer prognosis
- DNA Repair Mechanisms
- Kruppel-like factors research
- Veterinary medicine and infectious diseases
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Liver physiology and pathology
- Reproductive System and Pregnancy
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Genetic factors in colorectal cancer
- Protein Tyrosine Phosphatases
- Korean Peninsula Historical and Political Studies
- Single-cell and spatial transcriptomics
- Plant pathogens and resistance mechanisms
Hangzhou Medical College
2020-2025
Zhejiang Provincial People's Hospital
2025
Second Affiliated Hospital of Shantou University Medical College
2024
Shantou University
2022-2024
Tsinghua University
2019-2023
Guangxi University
2023
Gansu University of Traditional Chinese Medicine
2023
Shandong University
2022
Kunming Medical University
2022
Shantou University Medical College
2022
Abstract Plant genomes harbor dozens to hundreds of nucleotide‐binding site‐leucine‐rich repeat (NBS‐LRR) genes; however, the long‐term evolutionary history these resistance genes has not been fully understood. This study focuses on five Brassicaceae and Carica papaya genome explore changes in NBS‐LRR that have taken place this Rosid II lineage during past 72 million years. Various numbers were identified from Arabidopsis lyrata (198), A. thaliana (165), Brassica rapa (204), Capsella rubella...
BACKGROUND: Pathological cardiac hypertrophy can result in heart failure. Protein dephosphorylation plays a primary role the mediation of various cellular processes cardiomyocytes. Here, we investigated effects protein tyrosine phosphatase, PRL2 (phosphatase regenerative liver 2), on pathological hypertrophy. METHODS: The knockout mice were subjected to angiotensin II infusion or transverse aortic constriction induce myocardial and dysfunction. RNA-sequencing analysis was performed explore...
Cardiac fibrosis is a pathological change leading to cardiac remodeling during the progression of myocardial ischemic diseases, and its therapeutic strategy remains be explored. S100A4, calcium-binding protein, participates in fibrotic diseases with an unclear mechanism. This study aimed investigate role S100A4 fibrosis.Cardiac fibroblasts from neonatal C57BL/6 mouse hearts were isolated cultured. Myocardial infarction was induced by ligating left anterior descending coronary artery (LAD)....
<h3>Background & Aims</h3> Severe acute pancreatitis can easily lead to systemic inflammatory response syndrome and death. Macrophages are known be involved in the pathophysiology of (AP), macrophage activation correlates with disease severity. In this study, we examined role ubiquitin-specific protease 25, a deubiquitinating enzyme regulator macrophages, pathogenesis AP. <h3>Methods</h3> We used L-arginine, cerulein, choline-deficient ethionine-supplemented diet–induced models AP...
Five diets (D1, D2, D3, D4 and D5) containing 0, 50, 100, 150 200 g starch per kg diet were formulated to investigate the effects of level on largemouth bass, Micropterus salmoides. Fish (initial weight: 22.00 ± 0.02 g) fed five for 90 days. Results indicated that weight gain, specific growth rate survival fish higher dietary (200 g/kg) lower than those levels (0–50 g/kg). Higher (150–200 have a negative effect antioxidant ability (total superoxide dismutase: T-SOD; malonyldialdehyde: MDA;...
The Brother of Regulator Imprinted Sites (BORIS, gene symbol CTCFL) has previously been shown to promote colorectal cancer cell proliferation, inhibit apoptosis, and resist chemotherapy. However, it is unknown whether Boris plays a role in the progression situ cancer. Here knockout (KO) mice were constructed. function loss cloned mutation that was retained KO verified by testing its activities lines compared with wild-type gene. reduced incidence severity azoxymethane/dextran sulfate-sodium...
Abstract Identifying oncogenes that promote cancer cell proliferation or survival is critical for treatment of colorectal cancer. The Brother Regulator Imprinted Sites ( BORIS ) frequently expressed in most types cancer, but rarely normal tissues. Aberrantly relates to its function cells remains unclear. In addition, previous studies indicated the significance cytoplasm-localized cells. However, none them investigated function. Herein, we functions and apoptosis role expression correlated...
The chimeric RNA, SLC45A3-ELK4, was found to be a product of cis-splicing between the two adjacent genes (cis-SAGe). Despite biological and clinical significance its generating mechanism has not been elucidated. It shown in one cell line that binding transcription factor CTCF insulators located at or near gene boundaries, inversely correlates with level chimera. To investigate such cis-SAGe events, we sequenced potential regions may play role transcriptional read-through. We could detect...
Abstract The early diversification of angiosperms is thought to have been a rapid process, which may complicate phylogenetic analyses angiosperm relationships. Plastid and nuclear phylogenomic studies raised several conflicting hypotheses regarding overall phylogeny, but mitochondrial genomes largely ignored as relevant source information. Here we sequenced from 18 fill taxon‐sampling gaps in Austrobaileyales, magnoliids, Chloranthales, Ceratophyllales, major lineages eudicots monocots. We...
Liver fibrosis, a compensatory repair response to chronic liver injury, is caused by various pathogenic factors, and hepatic stellate cell (HSC) activation phenotypic transformation are regarded as key events in its progression. Ferroptosis, novel form of programmed death, also closely related different pathological processes, including those associated with diseases. Here, we investigated the effect doxofylline (DOX), xanthine derivative potent anti-inflammatory activity, on fibrosis well...
Brother of regulator imprinted sites (BORIS) is expressed in most cancers and often associated with short survival poor prognosis patients. BORIS inhibits apoptosis promotes proliferation cancer cells. However, its mechanism action has not been elucidated, there no known inhibitor BORIS.A phage display library was used to find the inhibitory peptides BTApep-TAT identified. The RNA sequencing profile BTApep-TAT-treated H1299 cells compared that BORIS-knockdown Antitumor activity evaluated a...
Circular RNAs (circRNAs), which are more stable than linear mRNAs and long non-coding (LncRNAs), detected in body fluids such as plasma, serum, exosomes. Disease-associated circRNAs have significant clinical roles due to their diagnostic prognostic values. Brother of regulator imprinting site (BORIS) promotes cancer progression is specifically highly expressed the majority carcinoma. However, mechanism underlying regulation by oncoprotein BORIS role regulating inflammation immunity remain be...
Tumor metastasis causes over 90% of cancer related death and no currently available therapies target it. However, there is limited understanding regarding the epigenetic regulation genes during this complex process. Here by integrating single-cell ATAC-seq (scATAC-seq), RNA-seq (scRNA-seq), microarray, bulk RNA-seq, immunohistochemistry (IHC) staining, as well proteomics datasets from paired primary liver metastatic colorectal (CRC) patient-derived xenograft (PDX) model patients, we...
Autophagy regulates many cell function related to cancer, including proliferation, invasion and apoptosis. Therefore, we investigated the potential value of crosstalk between autophagy The present study demonstrated that seven genes were screened from biological network salidroside (Sal) acting on liver cancer. GO analysis showed these mainly involved in apoptosis autophagy. KEGG regulated process cancer through Th17 differentiation, PI3K-Akt signaling pathway other pathways. Moreover,...
Advanced glycation end products (AGEs) accumulate in the retinal vascular cells, neurons, and glias of patients with diabetes mellitus lead to pathogenesis diabetic retinopathy (DR).In present study, elucidate orchestrated interactions high mobility group box 1 (HMGB1) silent mating type information regulation 2 homolog (Sirt 1) AGE-induced pro-inflammatory toxicity epithelial we investigated role HMGB1 Sirt cytokines chemokines.It was demonstrated that expression TNF-α, IL-1β, IL-6, MCP-1,...