A5100703520- Protein Hydrolysis and Bioactive Peptides
- NF-κB Signaling Pathways
- Epigenetics and DNA Methylation
- Lipid metabolism and disorders
- Receptor Mechanisms and Signaling
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Traditional Chinese Medicine Studies
- Neuroscience and Neuropharmacology Research
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Plant tissue culture and regeneration
- Angiogenesis and VEGF in Cancer
- Acupuncture Treatment Research Studies
- Aquaculture Nutrition and Growth
- Adenosine and Purinergic Signaling
- Congenital heart defects research
- Insect Utilization and Effects
- Sphingolipid Metabolism and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Alkaloids: synthesis and pharmacology
- Cell death mechanisms and regulation
- Phytochemistry and Biological Activities
Hunan Province Chest Hospital
2025
Wenzhou Medical University
2025
Dongyang People's Hospital
2025
Chengdu University of Traditional Chinese Medicine
2021-2024
Guangzhou University of Chinese Medicine
2009-2024
Shenzhen Pingle Orthopedic Hospital
2024
National Institutes of Pharmaceutical Research and Development (China)
2024
Tangshan Normal University
2023
Union Hospital
2007-2023
Huazhong University of Science and Technology
2014-2023
The nuclear protein high-mobility group box 1 (HMGB-1) promotes inflammation in sepsis, but little is known about its role brain ischemia-induced inflammation. We report that HMGB-1 and receptors, receptor for advanced glycation end products (RAGE), Toll-like 2 (TLR2), TLR4, were expressed normal cultured neurons, endothelia, glial cells. During middle cerebral artery occlusion (MCAO), mice, immunostaining rapidly disappeared from all cells within the striatal ischemic core h after onset of...
For making full use of aquatic by-products to produce high value-added products, Siberian sturgeon (Acipenser baerii) cartilages were degreased, mineralized, and separately hydrolyzed by five kinds proteases. The collagen hydrolysate (SCH) generated Alcalase showed the strongest 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·) hydroxide (HO·) scavenging activity. Subsequently, thirteen antioxidant peptides (SCP1-SCP3) isolated from SCH, they identified as GPTGED, GEPGEQ, GPEGPAG, VPPQD, GLEDHA,...
This study suggested that bioactive peptides from blue mussel could serve as a therapeutic alternative in the treatment of hypertension because their ACE inhibitory activity and protective effects on oxidative damaged HUVECs.
The aim of this study was to investigate the protective function and mechanism TCP3 (PKK), TCP6 (YEGGD) TCP9 (GPGLM) from skipjack tuna cardiac arterial bulbs on skin photoaging using UVB-irradiated HaCaT cell model. present results indicated that had significant cytoprotective effect cells (p < 0.001). Hoechst 33342 staining showed apoptosis UV-irradiated could be significantly reduced by treatment (GPGLM); JC-1 protect restoring mitochondrial membrane potential (MMP); Furthermore,...
Antarctic krill (Euphausia superba) is the world's largest resource of animal proteins and thought to be a high-quality for future marine healthy foods functional products. Therefore, was degreased separately hydrolyzed using flavourzyme, pepsin, papain, alcalase. Protein hydrolysate (AKH) prepared by trypsin showed highest Ca-chelating rate under optimized chelating conditions: pH 8.0, reaction time 50 min, temperature °C, material/calcium ratio 1:15. Subsequently, fourteen peptides were...
Excitotoxin-induced destruction of striatal neurons, proposed as a model Huntington's disease, involves process having the biochemical stigmata apoptosis. Recent studies suggested that transcription factor nuclear (NF)-κB may be involved in excitotoxicity. To further analyze contribution NFκB to excitotoxic neuronal death <i>in vivo</i>, changes binding activities and other factors well consequences inhibiting translocation were measured after infusion quinolinic acid (120 nmol) into rat...
Intergenomic gene transfer (IGT) is continuous in the evolutionary history of plants. In this field, most studies concentrate on a few related species. Here, we look at IGT from broader perspective, using 24 We discover many events by assessing data nuclear, mitochondrial and chloroplast genomes. Thus, summarize two roles mitochondrion: source pool. That is, mitochondrion gives massive sequences integrates nuclear transposons tRNA genes. Though directions are opposite, lots likenesses...
Diabetes is a recognized high-risk factor for the development of atherosclerosis, in which macroautophagy/autophagy emerging to play essential roles. The retention low-density lipoprotein (LDL) particles subendothelial space following transcytosis across endothelium initial step atherosclerosis. Here, we identified that high glucose could promote atherosclerosis by stimulating LDL. By inhibiting AMPK-MTOR-PIK3C3 pathway, suppresses CAV-CAVIN-LC3B-mediated autophagic degradation CAV1;...
Oxidative stress is the main factor responsible for induction of diabetic renal fibrosis. Thus, improving state oxidative can effectively prevent further deterioration nephropathy (DN). Previous research has shown that formononetin (FMN), a flavonoid with significant antioxidant activity and Sirt1 activation effect, improve However, exact mechanisms underlying effect FMN on fibrosis have yet to be elucidated. In this study, we carried out in vivo experiments db/db (diabetic) mouse model...
Background: Excessive inflammation results in severe tissue damage as well serious acute or chronic disorders, and extensive research has focused on finding new anti-inflammatory hit compounds with safety efficacy profiles from natural products. As promising therapeutic entities for the treatment of inflammation-related diseases, fusaproliferin its analogs have attracted great interest. However, underlying mechanism is still poorly understood deserves to be further investigated. Methods: For...
Cerebral preconditioning provides insights into endogenous mechanisms that protect the brain from ischemic injury. Hypoxia and anesthetic isoflurane are powerful agents. Recent data show sphingosine 1-phosphate receptor stimulation improves outcome in rodent models of stroke. Endogenous levels controlled by expression activity kinases (SPK). We hypothesize SPK upregulation mediates induced hypoxia reduces injury.Male wild-type C57BL/J, SPK1(-/-) SPK2(-/-) mice were exposed to or before...
Neuronal damage is correlated with vascular dysfunction in the diseased retina, but underlying mechanisms remain controversial because of lack suitable models which vasoregression related to neuronal initiates mature retinal vasculature. The aim this study was assess temporal link between and patency a transgenic rat (TGR) overexpression mutant cilia gene polycystin-2.Vasoregression, neuroglial changes expression neurotrophic factors were assessed TGR control rats time course. Determination...
Background Dipeptidyl peptidase 4 (DPP4) and angiotensin-converting enzyme (ACE) are important target enzymes in glycemic control renovascular protection. Here, we studied the effect of NWT-03, an egg protein hydrolysate with DPP4- ACE-inhibitory activity, on damage Zucker diabetic fatty (ZDF) rats. Comparisons were made to rats treated vildagliptin (VIL), included as a positive for DPP4 inhibition. Methods ZDF received NWT-03 (1 g/kg/day) or VIL (3 mg/kg/day) from 10 25 weeks age. Metabolic...
Tuberculous meningitis (TBM) is the most serious type of tuberculosis infection, and there a lack accurate diagnostic targets for TBM. Therefore, it great clinical public health significance to find specific target early diagnosis prediction prognosis From January 2021 February 2024, 110 TBM patients 122 with non-tumor, non-infectious headaches were admitted Hunan Chest Hospital. To compare two groups, cerebrospinal fluid (CSF) levels sCD163 MMP-9, as well serum NCAM1 protein levels,...
When the pulp is inflamed or injured, cell morphology, gene expression, and synaptic connections change occur in medullary dorsal horn, causing inflammation pain formatting pulpitis pain. To examine impact of lncRNA GATA3-AS1 regulation miR-17-3p on bioactivity lipopolysaccharides (LPS)-stimulated human dental stem cells (hDPSCs). The expression serum samples from patients with pulpitis, caries, healthy control was examined using RT-qPCR. verified GSE198359 dataset. hDPSCs were exposed to...