A5100615396- Semiconductor Lasers and Optical Devices
- Cancer-related molecular mechanisms research
- Conducting polymers and applications
- Photonic and Optical Devices
- Organic Light-Emitting Diodes Research
- Cancer-related gene regulation
- Solid State Laser Technologies
- Luminescence and Fluorescent Materials
- Wnt/β-catenin signaling in development and cancer
- Natural product bioactivities and synthesis
- Photorefractive and Nonlinear Optics
- S100 Proteins and Annexins
- RNA Research and Splicing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA modifications and cancer
- Hydrogels: synthesis, properties, applications
- Cancer Genomics and Diagnostics
- Polymer-Based Agricultural Enhancements
- Plant and Fungal Species Descriptions
- Organic Electronics and Photovoltaics
- Cancer Cells and Metastasis
- Plant Diversity and Evolution
- Circular RNAs in diseases
- Semiconductor Quantum Structures and Devices
- MicroRNA in disease regulation
Army Medical University
2025
China International Science and Technology Cooperation
2025
Southwest Hospital
2025
Union Hospital
2023
Huazhong University of Science and Technology
2023
Hunan Normal University
2010-2023
Chengdu University of Traditional Chinese Medicine
2022
Fudan University Shanghai Cancer Center
2015-2022
Shanghai Medical College of Fudan University
2022
Chengdu Fifth People's Hospital
2022
Abstract There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient‐derived organoid (PDO) has become an important preclinical model. Herein, a living biobank with 50 CRLM organoids derived from primary tumors paired metastatic lesions successfully constructed. PDOs the multiomics levels (histopathology, genome, transcriptome single‐cell sequencing) are comprehensively analyzed confirmed that this...
Abstract A series of π‐conjugated chelating polymers with charged iridium (Ir) complexes in the backbones were synthesized by a Suzuki polycondensation reaction, leading to homogeneous polymeric materials that phosphoresce red light. The fluorene and bipyridine (bpy) segments used as polymer backbones. 5,5′‐Dibromobipyridine served ligand form complex monomer 1‐(9′9‐dioctylfluorene‐2‐yl)isoquinoline (Fiq) cyclometalated ligand. Chemical photophysical characterization confirmed Ir...
Background: Excessive inflammation results in severe tissue damage as well serious acute or chronic disorders, and extensive research has focused on finding new anti-inflammatory hit compounds with safety efficacy profiles from natural products. As promising therapeutic entities for the treatment of inflammation-related diseases, fusaproliferin its analogs have attracted great interest. However, underlying mechanism is still poorly understood deserves to be further investigated. Methods: For...
HOXA11 antisense RNA (HOXA11-AS) has been shown to be involved in tumorigenesis and development of different cancers. However, the role HOXA11-AS non-small cell lung cancer (NSCLC) remains unclear. In this study, we firstly explored confirmed expression NSCLC tissues cells. Cytometry, CCK-8, scratch, migration, Matrigel invasion flow cytometry assays were performed determine biological impact vitro. Furthermore, a chick embryo chorioallantoic membrane (CAM) model was constructed explore...
It is worthwhile to establish a prognostic prediction model based on microenvironment cells (MCs) infiltration and explore new treatment strategies for triple-negative breast cancer (TNBC). The xCell algorithm was used quantify the cellular components of TNBC bulk RNA sequencing (bulk RNA-seq) data. MCs index (MCI) constructed using least absolute shrinkage selection operator Cox (LASSO-Cox) regression analysis. Single-cell (scRNA-seq), spatially resolved transcriptomics (SRT), multiplex...
Objectives We previously identified a hypomorphic variant, p.Arg90His (p.R90H) of neutrophil cytosolic factor 1 ( NCF1, regulatory subunit phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 complex), as an putative causal variant for systemic lupus erythematosus (SLE), and established knock-in (KI) H90 in the C57BL/6 background to study how this promotes development. Methods Wild type (WT) KI littermates were assessed immune profiles lupus-like features. Disease activity...
The altered expression of homeobox (HOX)A11 has been observed in various malignant tumor types, but it remained to be determined human lung adenocarcinoma (LUAD). In the present study, HOXA11 LUAD and potential associated mechanisms were assessed. Data from Cancer Genome Atlas Oncomine microarrays gathered in‑house polymerase chain reaction data produced investigate its association with clinicopathological characteristics. Genes co‑expressed also identified by searching cBioPortal Multi...
Previous studies have investigated the association between HOXA13 and non-small cell lung cancer. However, role of expression in occurrence progression adenocarcinoma (LUAD) has not yet been investigated. In present study, HOXA13-related data mining The Cancer Genome Atlas (TCGA), polymerase chain reaction (PCR) from our cases case information Oncomine was conducted for validation. cancer lines were also collected Cell Line Encyclopedia (CCLE) database further verification. A comprehensive...
Although the molecular studies of single gastrointestinal tumors have been widely reported by media, it is not clear about function small nucleolar RNA (snoRNA) in progression, development and prognostic significance colon adenocarcinoma, its certain mechanisms functions remain to be studied. This study aims dig out gene expression data profile adenocarcinoma construct pathology prediction-evaluation, ultimately revealing clinical value snoRNA adenocarcinoma. 932 differentially expressed...
A series of π-conjugated chelating polymers with charged iridium (Ir) complex units based on 1,10-phenanthroline in the backbones were synthesized by Suzuki polycondensation, and homogeneous polymeric phosphorescent materials obtained. 3,8-Dibromo-1,10-phenanthroline served as an N∧N ligand to form a Ir monomer 1-(9,9-dioctylfluorene-2-yl)isoquinoline (Fiq) cyclometalated ligands. Chemical photophysical characterization confirmed that was incorporated into one repeat units. Chelating showed...
Human YPEL4 is a member of YPEL family. It contains Yippee domain, which putative zinc-finger-like, metal-binding domain. The human gene maps to chromosome 11q12.1, ubiquitously expressed in adult tissues, and encodes nuclear protein 127 amino acids, the function remains unknown. To gain insights into cellular this protein, we searched for YPEL4-interacting proteins using yeast two-hybrid screen. major vault (MVP), lung resistance associated was identified as binding partner YPEL4....
Homeobox A1 (HOXA1) serves an oncogenic role in multiple cancer types. However, the of HOXA1 non‑small cell lung (NSCLC) remains unclear. In present study, use reverse transcription-quantitative polymerase chain reaction and databases The Cancer Genome Atlas (TCGA), Oncomine, Gene Expression Profiling Interactive Analysis Multi Experiment Matrix were combined to assess expression its co-expressed genes NSCLC. Bioinformatic analyses, such as Ontology (GO), Kyoto Encyclopedia Genes Genomes...
Abstract In this contribution, we demonstrate a new effective methodology for constructing highly efficient and durable poly( p ‐phenyleneethynylene) (PPE) containing emissive material with nonaggregating hole‐facilitating properties through the introduction of hole‐transporting blocks into PPE system as grafting coils well building energy donor–acceptor architecture between backbone. Poly(2‐(carbazol‐9‐yl)ethyl methacrylate) (PCzEMA), herein, is chosen blocks, incorporated via atom transfer...
Objectives Following up the systemic lupus erythematosus (SLE) genome-wide association studies (GWAS) identification of NMNAT2 at rs2022013, we fine-mapped its 150 kb flanking regions containing and SMG7 in a 15 292 case–control multi-ancestry population tested functions identified variants. Methods We performed genotyping using custom array, imputation by IMPUTE 2.1.2 allele specific quantitative real-time PCR luciferase reporter transfections. SLE peripheral blood mononuclear cells (PBMCs)...
A superabsorbent polymer (SAP) was synthesized by solution polymerization. The influence of synthesis technology studied and optimized, FTIR, SEM, TGA were used to characterize the structure morphology material. Under optimal conditions, water absorption material can achieve about 80% saturation value in first 20 min, absorbs distilled up 2013 g/g. SAP also has remarkable retention reswelling capability. excellent performance makes it have a promising application agriculture. In addition,...
We demonstrate the continuous wave p-polarized single longitudinal mode (SLM) operation of an Er:YAG laser at 1617.6nm pumped by a diode-laser with three inserted Fabry—Perot (FP) etalons room temperature. The Brewster angle FP is applied to obtain laser. For free running, maximum output power 570mW pump 12.5 W. An incident 12.5W used generate 78.5mW, corresponding slope efficiency 1.6% and optical-to-optical 0.61%. beam quality M2 measured be 1.15 highest SLM power. This stable polarized...
Abstract Background Retinitis pigmentosa (RP) is the most common type of inherited retinopathy. At least 69 genes for RP have been identified. A significant proportion RP, however, remains genetically unsolved. In this study, genetic basis a Chinese consanguineous family with presumed autosomal recessive retinitis (arRP) was investigated. Methods Overall ophthalmic examinations, including funduscopy, decimal best-corrected visual acuity, axial length and electroretinography (ERG) were...