A5088849156- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects of Natural Compounds
- Diet and metabolism studies
- Ion Channels and Receptors
- Neuroscience and Neuropharmacology Research
- Inflammasome and immune disorders
- Cancer therapeutics and mechanisms
- Pharmacological Effects and Toxicity Studies
- Phytoestrogen effects and research
- Inflammatory mediators and NSAID effects
- Bipolar Disorder and Treatment
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Gastroesophageal reflux and treatments
- Cholinesterase and Neurodegenerative Diseases
- Ion Transport and Channel Regulation
- Helicobacter pylori-related gastroenterology studies
- Piperaceae Chemical and Biological Studies
- Medicinal Plant Pharmacodynamics Research
- Nausea and vomiting management
- Gut microbiota and health
- Neutropenia and Cancer Infections
Huazhong University of Science and Technology
2016-2025
Union Hospital
2016-2025
China International Science and Technology Cooperation
2025
Army Medical University
2025
Southwest Hospital
2025
John Wiley & Sons (United States)
2023
Liechtenstein Institute
2023
Hudson Institute
2023
Wuhan Union Hospital
2021
Zhejiang Chinese Medical University
2007
Abstract Non‐alcoholic steatohepatitis (NASH) is a severe inflammatory phase of the non‐alcoholic fatty liver disease (NAFLD) spectrum and can progress to advanced stages NAFLD if left untreated. This study uses multi‐omics data elucidate underlying mechanism naringenin's reported benefit in alleviating (NASH). Male mice were fed NASH‐inducing (methionine‐choline‐deficient) MCD diet with or without naringenin supplementation for 6 weeks. Naringenin prevented NASH‐induced histopathological...
It is worthwhile to establish a prognostic prediction model based on microenvironment cells (MCs) infiltration and explore new treatment strategies for triple-negative breast cancer (TNBC). The xCell algorithm was used quantify the cellular components of TNBC bulk RNA sequencing (bulk RNA-seq) data. MCs index (MCI) constructed using least absolute shrinkage selection operator Cox (LASSO-Cox) regression analysis. Single-cell (scRNA-seq), spatially resolved transcriptomics (SRT), multiplex...
Traditional Chinese medicine Chaihu Shugan San (CSGS) is a classic herb prescription for improving depression, but its specific molecular mechanism has not been fully clarified. This study integrates network pharmacology and experimental validation to investigate CSGS's antidepressant effects, focusing on impact GC metabolism related pathways. In this research, the of CSGS in relation depression model induced by chronic unpredictable mild stress will be discussed. High-performance liquid...
Shugan Jieyu Capsule (SG) has been widely used in China to treat mild moderate depression. Hypericum perforatum L. (St John's Wort, SJW) is the main ingredient of SG and as herbal medicine depression western countries. However, it known that SJW low bioavailability does not easily get through blood-brain barrier. Therefore, how plays an antidepressant effect central nervous system (CNS) remains urgent problem be solved. Mounting research described relationship between antidepressants...
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide, CAP) is a naturally occurring alkaloid extracted from the fruit of Capsicum plant family. It represents an important ingredient in spicy foods consumed throughout world. However, little known about metabolic interactions between CAP and clinically used drugs. This study attempted to investigate effect on pharmacokinetics galantamine, competitive reversible cholinesterase inhibitor. CAP, dexamethasone or sodium salt carboxymethyl cellulose...
Diclofenac is a nonsteroidal anti-inflammatory drug used for the treatment of patients with osteoarthritis.Our primary objective was to compare bioavailability and tolerability generic sustained-release tablet established reference diclofenac sodium in fasting, healthy Chinese male population.A randomized, open-label, single- multiple-dose study design used. After single dose, volunteers received once daily 5 days. In single-dose phase, blood samples were collected from 0 36 hours after...
Abstract Capsaicin ( trans‐8‐methyl‐N‐vanillyl‐6‐nonenamide , CAP) is an important ingredient in spicy foods consumed throughout the world. Vinblastine (VBL) a naturally occurring alkaloid prescribed to cancer patients. Many patients treated with VBL were taking CAP at same time. This study attempted investigate effect of on pharmacokinetics VBL, which substrate CYP3A, P‐gp, and Mrp2. CAP, cyclosporine (CsA) or olive oil was given rats for seven consecutive days, seventh day, (1.3 mg/kg)...
1. Capsaicin (CAP) is the primary pungent principle in peppers and an inhibitor of CYP3A subfamily P-gp.2. Pitavastatin mainly metabolized via glucuronidation metabolism by hepatic CYPs minimal. taken up Oatp1b2 (encoded Slco1b2) rat.3. The pharmacokinetics results showed that AUC Cmax group pre-treated with 3 mg/kg/d CAP were increased 1.2 fold 1.6 fold; 8 2.1 (p < 0.05) 2.9 0.05); 25 2.0 1.9 fold. RT-PCR data indicated pretreatment had little influence on mRNA expression level Slco1b2...
Abstract Many amino acid neurotransmitters in urine are associated with chronic stress as well major depressive disorders. To better understand depression, an analytical LC‐MS/MS method for the simultaneous determination of 11 underivatized (4‐aminohippurate, 5‐HIAA, glutamate, glutamine, hippurate, pimelate, proline, tryptophan, tyramine, tyrosine and valine) a single run was developed. The advantage this is simple preparation that there no need to deconjugate samples. quantification range...
Breast cancer resistance protein (BCRP/Abcg2 in human, Bcrp/Abcg2 rat), a member of the ATP-binding cassette (ABC) transporter family, acts as an efflux pump for xenobiotics, with ability to transport various drugs out cells. Capsaicin may have potential modulate function Bcrp transport. This study was evaluate effects capsaicin on pharmacokinetics sulfasalazine, substrate, rats and investigate mechanism this food-drug interaction.The were pre-treated 5% carboxymethylcellulose sodium...
A sensitive and specific high-performance liquid chromatography-tandem mass spectrometry method has been developed to determine the pharmacokinetic interactions of antiplatelet agents aspirin clopidogrel combined with dl-3-n-butylphthalide. For determination metabolite salicylic acid, inactive SR26334 NBP prototype drug in rat plasma, plasma samples were prepared by precipitation proteins using methanol containing 0.1% formic followed centrifugation. Chromatography was performed on a C18...
Aprepitant (APT), an antiemetic drug belonging to the class of substance P antagonists is efficiently used in both acute and delayed chemotherapy-induced nausea vomiting. Nausea vomiting induced by imatinib (IMA) as a chemotherapeutic could be reduced APT. This study investigated effect APT on pharmacokinetics IMA its major metabolite N-desmethyl (N-D IMA) rats mechanism this drug-drug interaction. The results indicated that after 3 days pretreatment with (10 mg/kg), blood concentration was...