A5086812553- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Medical Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Ultrasound in Clinical Applications
- Advanced SAR Imaging Techniques
- Cancer-related gene regulation
- Thermal Regulation in Medicine
- Respiratory Support and Mechanisms
- Probabilistic and Robust Engineering Design
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Mathematical Biology Tumor Growth
- Hepatocellular Carcinoma Treatment and Prognosis
- Nonlinear Dynamics and Pattern Formation
- Cytokine Signaling Pathways and Interactions
- COVID-19 diagnosis using AI
- Biopolymer Synthesis and Applications
- Molecular Biology Techniques and Applications
- Mathematical and Theoretical Epidemiology and Ecology Models
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- COVID-19 epidemiological studies
- Cancer Research and Treatments
- Sarcoma Diagnosis and Treatment
Zhejiang University
2021-2025
Huzhou University
2017-2024
Hunan Normal University
2014-2023
Hunan Provincial People's Hospital
2019-2023
Peking University
2020-2023
Peking University Cancer Hospital
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Harbin University of Commerce
2022
Fourth Affiliated Hospital of Anhui Medical University
2021
Anhui Medical University
2021
Tumor microenvironment and host immunity are closely related to outcome in patients with mantle cell lymphoma ( MCL ). However, few researchers have focused on the prognostic value of peripheral blood lymphocyte subsets counts. The purpose this study was investigate absolute monocyte Sixty‐eight were analyzed retrospectively. Absolute CD 4 + T counts ACD 4C), 8 counts, nature killer 4/ ratios assessed by flow cytometry correlated clinical parameters long‐term outcomes. median follow‐up for...
Angiotensin II (Ang II) induces a prominent and sustained nitration activation of ERK1/2 in rat vascular smooth muscle cells, both mediated via AT1 receptor. Nitration was also shown for recombinant non‐activated extracellular signal‐regulated kinase (ERK) MEK. phosphorylation by Ang significantly inhibited NAD(P)H inhibitors scavengers oxygen nitrogen reactive species completely blocked selective inducible nitric‐oxide synthase inhibitor. MEK inhibitor U0126 did not affect ERK but...
Previous studies have shown that the renin-angiotensin system (RAS) plays an important role in pathogenesis of hepatic fibrosis, and blockers RAS may be active as antifibrogenic goal. However, potential inhibition on expression transforming growth factor (TGF)-beta-Smads fibrosis remains unknown. The aim this study was to investigate effect mechanism angiotensin-converting enzyme inhibitor (perindopril) angiotensin II receptor blocker (valsartan) TGF-beta1 TGF (TRII) mRNA, Smad3 Smad7...
Previous studies have demonstrated that Smyd1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization. In this study, we uncovered novel function of the regulation endothelial cells (ECs). Our data showed is expressed vascular cells, knockdown SMYD1 impairs EC migration tube formation. Furthermore, Co-IP GST pull-down assays associated with Serum Response Factor (SRF). EMSA further forms complex SRF enhances DNA binding activity. indicate...
Abstract Objective To investigate the protective effect and possible mechanisms of vitamin B6 against renal injury in patients with sepsis. Methods A total 128 sepsis who met entry criteria multiple centres were randomly divided into experimental (intravenous therapy) control 0.9% sodium chloride groups based on usual care. Clinical data, inflammatory response indicators interleukin 6 (IL-6), 8 (IL-8), tumour necrosis factor (TNF-α) endothelin-1 (ET-1), oxidative stress superoxide dismutase,...
Primary gastric high-grade B-cell lymphoma (HGBL) is a special type of non-Hodgkin's lymphoma. So far, the genetic features this tumor have not been well characterized. Recently, high incidence BCL6 rearrangements has detected in HGBL. However, no previous cytogenetic studies found translocations involving locus (3q27) HGBL, and basis underlying remains unclear. We therefore characterized partner genes five primary HGBLs with rearranged gene by analyzing transcripts using 5′ RACE (rapid...
Wnt/β-catenin signaling plays a key role in pathological cardiac remodeling adults. The identification of tissue-specific interaction factor may provide clinical targeting strategy. Drosophila Pygo encodes the core Wnt/β-catenin. Two homologs (Pygo1 and Pygo2) have been identified mammals. Different from ubiquitous expression profile Pygo2, Pygo1 is enriched tissue. However, mammalian disease yet to be elucidated. In this study, we found that was upregulated human tissues with hypertrophy....
Abstract Background Retinitis pigmentosa (RP) is the most common type of inherited retinopathy. At least 69 genes for RP have been identified. A significant proportion RP, however, remains genetically unsolved. In this study, genetic basis a Chinese consanguineous family with presumed autosomal recessive retinitis (arRP) was investigated. Methods Overall ophthalmic examinations, including funduscopy, decimal best-corrected visual acuity, axial length and electroretinography (ERG) were...
Replication error (RER) phenotype, caused by deficiency of DNA mismatch repair genes and revealed widespread microsatellite instability, has been detected in subsets a wide variety solid tumors, but rarely lymphomas general. So far, the involvement RER phenotype pathogenesis gastric lymphoma mucosa-associated lymphoid tissue (MALT) type not conclusively established. We therefore examined 9 loci on 5 chromosomes [D2S123, D3S11, D3S1261, D3S1262, D3S1265, D6S262, D18S559, CTTT(T) repeat intron...
The presence of the bcl‐6 gene hypermutation was studied in 40 Hong Kong Chinese patients with diffuse large B‐cell lymphoma. primary sites involvement were nodal 18 cases and gastric 22. Hypermutations at E1.11 segment detectable 16/22 (73%) 4/18 (22%) lymphoma ( P < 0.01). Three 22 but none had mutations E1.12. proportion hypermutated group rearrangement similar to that germ‐line (70% v 75%). High frequency hypermutations found stomach they independent as detected by Southern analysis....
Longevity Assurance 5 (LASS5), a member of the LASS/Ceramide Synthases family, synthesizes C16-ceramide and is implicated in tumor biology. However, its precise role not yet well understood. A yeast two-hybrid screen was performed using human cDNA library to identify potential LASS5- interaction partners. One identified clone encodes succinate dehydrogenase subunit B (SDHB). Mammalian assays showed that LASS5 interacts with SDHB, result also confirmed by GST pull-down coimmunoprecipitation...
Ortleppascaris sinensis is the dominant nematode species infecting gastrointestinal tract of captive Chinese alligator, a critically endangered species. Gastrointestinal infection may cause loss appetite, growth, development disorder, and even mortality in alligators, especially young ones. This research first establishment loop-mediated isothermal amplification (LAMP) assay rapidly identifying O. sinensis, upon basis complete internal transcribed spacers (ITS) gene. Eight sets primers were...