A5050126444- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Effects of Radiation Exposure
- Mechanical and Optical Resonators
- Radiomics and Machine Learning in Medical Imaging
- Computational Drug Discovery Methods
- Pharmaceutical and Antibiotic Environmental Impacts
- Quantum Mechanics and Non-Hermitian Physics
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Water Treatment and Disinfection
- Sirtuins and Resveratrol in Medicine
- Advanced Battery Materials and Technologies
- Histone Deacetylase Inhibitors Research
- Inflammatory Biomarkers in Disease Prognosis
- Spectroscopy and Quantum Chemical Studies
- Inhalation and Respiratory Drug Delivery
- Microbial Natural Products and Biosynthesis
- Biofield Effects and Biophysics
- Bioinformatics and Genomic Networks
- Neurobiology and Insect Physiology Research
- Breast Lesions and Carcinomas
- Quantum Electrodynamics and Casimir Effect
- Heavy Metal Exposure and Toxicity
- Neuroblastoma Research and Treatments
Hangzhou Normal University
2024
Fudan University Shanghai Cancer Center
2020-2024
Shanghai Medical College of Fudan University
2019-2024
Shanghai Clinical Research Center
2024
Shanghai Institute of Hematology
2024
Huaqiao University
2024
Fudan University
2019-2020
Abstract There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient‐derived organoid (PDO) has become an important preclinical model. Herein, a living biobank with 50 CRLM organoids derived from primary tumors paired metastatic lesions successfully constructed. PDOs the multiomics levels (histopathology, genome, transcriptome single‐cell sequencing) are comprehensively analyzed confirmed that this...
Triple-negative breast cancer (TNBC) poses a therapeutic challenge due to its aggressive nature and lack of targeted therapies. Epigenetic modifications contribute TNBC tumorigenesis drug resistance, offering potential targets. Recent advancements in three-dimensional (3D) organoid cultures, enabling precise screening, hold immense promise for identifying novel compounds targeting TNBC. In this study, we established two patient-derived organoids implemented high-throughput screening system...
Metformin (MET), a worldwide used drug for type 2 diabetes, has been found with the largest amount by weight among all drugs in aquatic environment, including drinking water systems where this emerging micropollutant is inevitably transformed during chlorination process. Whether MET byproducts Y (C4H6ClN5) and C (C4H6ClN3) exist remains unknown. Although health-promoting properties, whether or how its affect health still uncharacterized. Here we reveal that byproduct are present highest...
Organoids are three-dimensional structures that closely recapitulate tissue architecture and cellular composition, thereby holding great promise for organoid-based drug screening. Although growing in provides the possibility organoids to main features of corresponding tissues, it makes incommodious imaging two-dimensional identifying surviving from surrounding dead cells after being treated by irradiation or chemotherapy. Therefore, significant work remains establish high-quality controls...
BackgroundDachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. However, the roles of DACH1 cell stemness tumorigenesis remain largely undefined.MethodsWe used immunohistochemistry, western blotting quantitative real-time PCR to analyse expression cancer (CRC) samples. CRISPR/Cas9 gene editing lentiviral vector-mediated overexpression shRNA-mediated knockdown were utilized modulate lines organoids. An organoid-based functional model was...
Abstract Purpose Breast cancer (BC) is diagnosed as the most common in women 2022 according to American Cancer Society. It essential detect early and treat early. Several studies have shown that some blood parameters important predictive value for BC. In this study, we aim explore whether immune‐associated are relevant disease‐free survival (DFS) early‐stage Methods A single‐center, regression cohort study of 1490 patients with BC Shanghai Center was conducted from January 2008 December...
The objective of this study is to comprehensively evaluate the therapeutic efficacy postmastectomy radiotherapy (PMRT) in treating patients with pT3N0-1M0 breast cancer within context modern strategies.
Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury, although the repair mechanisms are unclear. Here, we found that Bach2 deficiency promotes epithelial cell proliferation during homeostasis. Moreover, genetic inactivation of in mouse epithelium facilitated crypt irradiation, resulting a reduction mortality. RNA-sequencing analysis isolated crypts revealed altered expression numerous genes, including those regulating double-strand break...
Epithelial regeneration is critical for barrier maintenance and organ function after intestinal radiation injury. Accumulating evidence indicates that the interleukin family members play roles in stem-cell-mediated epithelial regeneration. However, little known about relationship between 33 (IL-33)/ST2 axis We demonstrate here IL-33 expression significantly increased treatment. Deficiency of IL-33/ST2 promotes regeneration, resulting a reduction mortality during radiation-induced intestine...
Estrogen is very important to the differentiation of B lymphocytes; lymphopoiesis induced by OVX was supposedly involved in osteoporosis. But effects lymphocytes on osteogenic bone mesenchymal stem cells (BMSCs) are not clear. In this study, we detected quality and loss a trabecular electronic universal material testing machine microcomputed tomography (micro-CT) splenectomized-ovariectomy (SPX-OVX) rats. Additionally, changes (B lymphocyte, CD4+ CD8+ T lymphocytes, macrophages) marrow were...
Dear Editor, Patients diagnosed with metastatic colorectal cancer (mCRC) often suffer from unresectable metastases, which lead to a rather poor prognosis.1 Although efforts have been made, the need for personalized therapy mCRC patients is still urgent. Human CRC organoids derived patients' primary tumor samples closely recapitulate several properties of original and provide platform design.2, 3 However, dependence resected PDO model limited its application in patients. Circulating cells...
The fundamental concept underlying topological phenomena posits the geometric phase associated with eigenstates. In contrast to this prevailing notion, theoretical studies on time-varying Hamiltonians allow for a new type of phenomenon, known as dynamics, where evolution process allows hidden invariant continuous flows. To validate conjecture, we study chiral and nonreciprocal dynamics by encircling exceptional points (EPs) non-Hermitian in trapped ion system. These are topologically robust...
To explore novel terpenoid repellents, 22 candidate derivatives were synthesized and tested for their electroantennogram (EAG) responses repellent activities against
In recent years, some components and active ingredients from the herbal formula “eight famous herbals in Zhejiang” (Zhe-Ba-Wei) have been reported to possess antitumor properties. However, there is still no systemic study on role mechanism of Zhe-Ba-Wei cancer. To systematically investigate anticancer efficacy Zhe-Ba-Wei, we first identified 17 with gene targets associated various types tumors. Second, screened these their responding multiple shared by analyzing convergence diverse...
Recently, experiments aimed at measuring gravity mediated entanglement (GME) using quantum information techniques have been proposed, based on the assumption that if two systems get entangled through local interactions with gravitational field, then this field must be quantum. While there is a debate about what could drawn from GME, simulation might provide some clarification. Here, we present electromagnetic analogy of GME magnetic-field interaction between electron and nucleus in single...
Objective To establish an intestinal organoid-based assay to investigate the radiation mitigation effect of epiregulin in vitro. Methods Intestinal crypts were released from tissue incubated with EDTA. Intestinal seeded 3D matrigel irradiated at 24 h after plating. The was evaluated by measuring survival rate, size and budding numbers organoid irradiation, basic FGF used as a positive control epiregulin. Results Radiation-induced lethality dose-dependent curve consistent vivo...