A5103189487- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- Tissue Engineering and Regenerative Medicine
- Cancer Diagnosis and Treatment
- Neurological Complications and Syndromes
- Renal Transplantation Outcomes and Treatments
- Adenosine and Purinergic Signaling
- Immune Cell Function and Interaction
- Congenital Anomalies and Fetal Surgery
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Hybrid Renewable Energy Systems
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Polyomavirus and related diseases
- Transplantation: Methods and Outcomes
- Gestational Trophoblastic Disease Studies
- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Acute Lymphoblastic Leukemia research
Soochow University
2012-2024
First Affiliated Hospital of Soochow University
2012-2024
Tianjin Nankai Hospital
2018
We conducted a single-arm, open-label, single-center phase 1 study to assess the safety and efficacy of multicycle-sequential anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in combination with autologous CD19+ feeding T cells (FTCs) tyrosine kinase inhibitor (TKI) as consolidation patients under age 65 years de novo Ph-positive B-cell acute lymphoblastic leukemia. Participants were given induction chemotherapy well systemic TKI. Afterward, they received single cycle CD19 CAR...
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is closely associated with airway inflammation including monocytes, lymphocytes, and neutrophils. Monocytes play an essential role in the pathogenesis (COPD). To elucidate association circulating monocyte alteration AECOPD, we analyzed subpopulation peripheral blood 16 healthy volunteers 22 AECOPD patients at stages admission remission after clinical therapy. We found a dramatic increase previously unreported population...
To compare the differences of biological characteristics between human umbilical cord-derived mesenchymal stem cells (UC-MSCs) cultured by serum-free medium or fetal bovine serum-contained complete to establish a xenogeneic protein-free UC-MSCs culture system.Healthy cord segments were digested with collagenase. MesenCult-XF and FBS-based αMEM medium, then analyzed morphology, immunophenotype, expansion potential, lineage differentiation karyotype immunosuppression early passages.The average...
This study was purposed to explore the correlation of regenerating Islet-derived 3-alpha(Reg3α) protein level in plasma with diagnosis and prognosis gastrointestinal acute graft-versus-host disease (GI-aGVHD) after all-HSCT, 103 patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) were observed our hospital from December 2011 2012. Peripheral blood samples routinely collected at 9 d before allo-HSCT, 0 d, 14 28 allo-HSCT as well aGVHD 1 4 weeks therapy. The...
This study was purposed to investigate the engraftment, graft-versus-host disease (GVHD), transplantation related mortality (TRM), relapse and survival in hematologic patients received unrelated umbilical cord blood (UCBT). A total of 25 with hematological underwent UCBT, including 8 pediatric 17 young adult patients. Among them 3 cases single unit UCBT 22 double units UCBT. For donor/recipients human leukocyte antigen (HLA) matching: HLA 6/6 loci matched 9 cases, 4-5/6 16 cases. There were...
This study was aimed to explore the method for induction and expansion of EB virus specific cytotoxic T lymphocytes (EBV-CTL) in vitro, detect their killing effect. Peripheral blood mononuclear cells (PBMNC) were collected from 6 EBV seropositive healthy donors, EBV-transformed B lymphoblastoid (BLCL)were used as antigen-presenting antigen stimulant which irradiated by 40 Gy (60)Co irradiator. The autologous PBMNC BLCL cultured induce expand EBV-CTL, immunophenotype identified flow...
Viral infections remain the common cause of morbidity and mortality in immunocompromised patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT).Virus antigens can be recognized by cytotoxic T-lymphocytes (CTL) context HLA class Ⅰ molecules.T-cell-based immunotherapies are now being included clinical practice transplant recipients to prevent treat viral complications associated with CMV,AdV EBV.Here,the current status future feasibility CTL immunotherapy for virus...
Objcetive To study the chimerism status ot bone marrow mesenchymal stem cells (BMSC) following double-unit cord blood cell transplantation (DCBT).Methods Bone mononuclear were isolated by ficoll density gradient centrifugation from patient DCBT and healthy donors.After cultured for about 20 days,BMSC surface makers,the ability to differentiate into adipocytes osteoblast expression of hematopoietic immune molecules detected,moreover,chimerism BMSC also evaluated STR-PCR.Results MSC derived...
To compare the clinical efficacy and safety of hypomenthylating agents (HMA) combined with Venetoclax (VEN) half dose priming regimen (CAG-like) in treatment elderly patients newly diagnosed acute myeloid leukemia (AML) who were not suitable for intensive chemotherapy.The data 43 AML chemotherapy our hospital from April 2019 to October 2020 retrospectively analyzed. Among them, 16 cases received HMA-VEN 27 HMA-CAG-like regimen. The remission rate, early mortality survival compared between...