A5051281073- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Virus-based gene therapy research
- Synthesis and Characterization of Heterocyclic Compounds
- CAR-T cell therapy research
- DNA and Nucleic Acid Chemistry
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Bone and Joint Diseases
- Circular RNAs in diseases
- Biopolymer Synthesis and Applications
- Bacterial Identification and Susceptibility Testing
- Extracellular vesicles in disease
- Immunodeficiency and Autoimmune Disorders
- Aerodynamics and Acoustics in Jet Flows
Xi'an Jiaotong University
2023-2024
Fujian Medical University
2013-2023
Union Hospital
2012-2023
Tokushima University
2023
Rural Resources
2014
First Affiliated Hospital of Fujian Medical University
2007
Fujian Institute of Microbiology
1994
Antwerp University Hospital
1989
University of Antwerp
1989
Background: Bloodstream infection (BSI) is a common and serious complication after patients with hematologic malignancies (HM) receiving chemotherapy.This study examined real-world data seeking to characterize HM BSI identify risk factors for emergence mortality.Methods: We retrospectively analyzed the pathogenic epidemiology, antibiotic resistance, in single-center cohort including 3014 consecutive chemotherapy between 2013 2016.Results of epidemiology were validated via comparison...
// Yan-Ling Zeng 1, 2, * , Hao Zheng Qiu-Ru Chen Xiao-Hong Yuan 1 Jin-Hua Ren Xiao-Feng Luo Ping Zhe-Yao Lin 2 Shao-Zhen Xue-Qiong Wu Min Xiao Yong-Quan Zhi-Zhe Jian-Da Hu Ting Yang Department of Hematology, Fujian Institute Provincial Key Laboratory Medical University Union Hospital, Fuzhou 350001, P. R. China Affiliated Nanping First Hospital University, 353000, These authors are regarded as co-first author Correspondence to: Yang, email: yang.hopeting@gmail.com Hu, drjiandahu@163.com...
The evolution of transient flow structures and mass transport in cavitating around a pitching hydrofoil is investigated qualitatively quantitatively, the interaction between cavitation patterns vortices elucidated from Lagrangian viewpoint. First, turbulence effects are estimated by density-corrected k–ω model to account for local compressibility multiphase at Reynolds number Re=6.4×105. Then, formation vorticity during whole cycle analyzed using averaged deviation method. By comparing...
NOTCH1 mutations occur in approximately 10% of patients with chronic lymphocytic leukemia (CLL). However, the relationship between genetic aberrations and tumor cell drug resistance or disease progression remains unclear. Frameshift deletions were detected by gene sequencing PEST domain three naive CLL patients. These associated chromosomal abnormalities including trisomy 12 13q deletion. Of note, one developed Richter's transformation during FCR treatment. Immunofluorescent western blot...
The aim of this study was to explore the predictive value procalcitonin (PCT) in Gram-negative bloodstream infections (BSIs) hematological patients with febrile neutropenia. A total 1466 samples (396 blood culture (BC)-positive, 1052 BC-negative, and 18 contaminated specimens) were included, comprising 268 Gram-negative, 88 Gram-positive, 19 fungal, 21 polymicrobial BSIs. Median PCT (0.72 ng/mL; IQR: 0.23-3.87) significantly higher than Gram-positive (0.34 0.14-2.23; p < .01), or fungal...
Chronic lymphocytic leukemia (CLL) is characterized by high heterogeneity in clinical features and outcomes Western countries China. In this study, the laboratory data of 210 CLL patients who were admitted to a single center China between 2002 2011 retrospectively analyzed. had median age 60.2 years (range, 35-92 years) occurred more often elderly female than male (female:male, 1.2:1). The overall response rate [ORR, complete remission (CR) + partial (PR)] entire cohort was 69.5% survival...
Regulatory T cells (Tregs), a subset of CD4+ cells, may exert inhibitory effects on alloimmune responses including acute graft-versus-host disease (aGVHD), and several microRNAs are implicated in the pathophysiological process GVHD. Therefore, we aimed present study to characterize functional relevance epidermal growth factor (EGF)-stimulated microRNA-21 (miR-21) regulating bone marrow-derived mesenchymal stem (BMSCs) mouse model aGVHD. We first isolated cultured BMSCs Tregs. Then, examined...
High-grade B-cell lymphoma (HGBL) is a newly introduced category of rare and heterogeneous invasive (BCL), which diagnosed depending on fluorescence in situ hybridization (FISH), an expensive laborious analysis. In order to identify HGBL with minimal workup costs, total 187 BCL patients were enrolled cohort study. As result, the overall survival (OS) progression-free (PFS) group inferior those non-HGBL group. (n = 35) was more likely have high-grade histomorphology appearance, extranodal...
The present study aimed to establish an induced pluripotent stem cell (iPSC) line from acute myelogenous leukemia (AML) cells in vitro and identify their biological characteristics.Cells the AML-infiltrated skin M6 patient were infected with a lentivirus carrying OCT4, SOX2, KLF4 C-MYC induce iPSCs. characteristics of iPSCs confirmed by alkaline phosphatase (ALP) staining. proliferation ability was detected CCK-8 assay. expression pluripotency markers measured immunostaining, cell-related...
Haplo-HSCT has been used when HLA-matched siblings are not available. Conditioning regimens aim to reduce tumor burden prior HSCT and provide sufficient immunoablation. We report the outcome of haplo-HSCT in 63 consecutive patients from 2/2013 12/2015 (19 females/44 males) with high-risk or relapsed/refractory hematological malignancies (n=29-AML; 8-sAML; 19-ALL; 5-advanced-MDS; 2-CML-BC). Median age was 20 years (range: 1.1-49). Twenty-one achieved remission transplant, while 42 did not....
Background Survivin is a rather specific gene in tumor tissue. We transfected dendritic cells (DCs) with recombinant adenovirus (Ad) containing survivin and granulocyte-macrophage colony-stimulating factor (GM-CSF) tested the inducing effect of DCs on cytotoxic T lymphocytes (CTL) to kill leukemic cells. Methods After derived from peripheral, was assayed by mixed leukocyte reaction (MLR) tests. Lactate dehydrogenase (LDH) release test used evaluate cytotoxicity CTL. Results Expression...
Ultra early posttransplantation lymphoproliferative disorder (PTLD) is a rare and fatal complication after hematopoietic stem cell transplantation (HSCT). Here we report, by lymph node (LN) flowcytometry, that recognized ultra PTLD an HLA-matched sibling allo-HSCT followed successful treatment with anti-CD20 antibody (rituximab) in patient progress disease for angioimmunoblastic T-cell lymphoma (AITL). The was conditioned reduced intensity conditioning (RIC) regimen. One week...
Abstract Hematological malignancies are increasingly treated with allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Unfortunately, iron overload is a frequent adverse effect of allo‐HSCT and associated poor prognosis. In the present study, we investigated hematopoiesis in iron‐overloaded mice elucidated effects on bone marrow (BM) microenvironment. Iron‐overloaded BALB/C were generated by injecting 20 mg/mL saccharated oxide intraperitoneally. Hematoxylin‐eosin staining was...
Abstract Killer cell immunoglobulin‐like receptor (KIR) receptor‐ligand mismatch has been shown to be protective for acute and chronic graft‐versus‐host disease (aGVHD, cGVHD) following allogeneic hematopoietic stem transplantation (allo‐HSCT) leukemia. Mesenchymal cells (MSC) have considered as one of the most promising prophylaxis severe GVHD. However, there are no prospective or retrospective studies determining whether they can work synergistically on To investigate potential influence...
To compare the differences of biological characteristics between human umbilical cord-derived mesenchymal stem cells (UC-MSCs) cultured by serum-free medium or fetal bovine serum-contained complete to establish a xenogeneic protein-free UC-MSCs culture system.Healthy cord segments were digested with collagenase. MesenCult-XF and FBS-based αMEM medium, then analyzed morphology, immunophenotype, expansion potential, lineage differentiation karyotype immunosuppression early passages.The average...
The energy transport in aero-acoustics is investigated the Lagrangian frame. First, based on finite-time Lyapunov exponent (FTLE) and momentum potential theory, a approach proposed to identify barriers of acoustic energy. Specifically, method, named relative flux gradient (RFG), presented detail. Then, verify it applied analytical fields, showing that could reveal wavefronts depending time interval computation. Moreover, RFG analyze simulated flow field an open cavity flow, results are...