A5102788566- Breast Cancer Treatment Studies
- Spinal Fractures and Fixation Techniques
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Spine and Intervertebral Disc Pathology
- Respiratory viral infections research
- DNA Repair Mechanisms
- Scoliosis diagnosis and treatment
- Breast Lesions and Carcinomas
- Influenza Virus Research Studies
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Animal Virus Infections Studies
- Anesthesia and Pain Management
- Gallbladder and Bile Duct Disorders
- MRI in cancer diagnosis
- RNA Research and Splicing
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- PARP inhibition in cancer therapy
- Systemic Lupus Erythematosus Research
Beijing Information Science & Technology University
2025
Guangzhou Medical University
2018-2025
State Key Laboratory of Respiratory Disease
2022-2025
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2024
First Hospital of China Medical University
2010-2024
China Medical University
2010-2024
Xi'an Medical University
2024
Yunnan University
2024
Inner Mongolia Medical University
2006-2023
Guangzhou Experimental Station
2022
The ellipse fitting (EF) algorithm has attracted extensive attention in phase demodulation schemes for eliminating nonlinear errors. When the amplitude of change interference spectrum caused by signal to be measured is weak, error EF results large, which leads failure and differential-cross-multiplying (EF-DCM) demodulation. This paper proposes a presetting parameters (PEP-DCM) scheme based on an orthogonal Fabry–Perot fibre optic acoustic sensor. sensing system sensitive strong sound...
Atherosclerosis (AS) seriously affects human health. The role of microRNAs (miRNAs) in the pathogenesis and progression AS has become a focus research. Our goal was to identify biological effect differentially expressed miRNAs (DE-miRNAs) AS.To analyze genes (DEGs), including mRNAs (DE-mRNAs) DE-miRNAs, by using Gene Expression Omnibus (GEO) database limma package. DEGs protein-protein interaction (PPI) network functional enrichment analysis were constructed search tool for retrieval...
The incidence of melanoma, the most aggressive and life-threatening form skin cancer, has significantly risen over recent decades. Therefore, it is essential to identify mechanisms that underlie melanoma tumorigenesis metastasis explore novel effective treatment strategies. Accumulating evidence s uggests aberrantly expressed long noncoding RNAs (lncRNAs) have vital functions in multiple cancers. However, lncRNA remain unclear. In this study, we investigated messenger RNA (mRNA) expression...
DNA‑dependent protein kinase catalytic subunit (‑PKcs) is the core involved in non‑homologous end‑joining repair of double‑strand breaks. In addition, it can form a complex with poly(ADP‑ribose) polymerase 1 (PARP1), which catalyzes PARylation. However, unclear how DNA‑PKcs interacts PARP1 DNA damage response and PARylation affects DNA‑PK activity. Using immunoprecipitation, immunofluorescence flow cytometry present study found that was PARylated after damage, PARP1/2 inhibitor olaparib...
Preoperative assessment of nodal stage is importance in breast cancer treatment decision-making. This study was done to determine the power combined mammography and ultrasonography differentiating N0–N1 from N2–N3 cancer. We retrospectively reviewed clinical data 3944 female patients with invasive by preoperative between January 2006 December 2013 at our hospital. Pathological diagnosis available for each patient. Sensitivity, specificity, positive predictive value (PPV), negative (NPV),...
Serum hepatitis B surface antigen (HBsAg) level has been developed as an important marker to predict treatment outcome recent years. The authors aimed identify the correlation between quantitative HBsAg and virus (HBV) DNA in chronic (CHB) patients explore whether can be used a surrogate of serum HBV for CHB patients. One hundred seventy‐three were included this study. Patients divided into two groups: Hepatitis e (HBeAg) positive negative There was HBeAg ( r = 0.509, P < 0.001) poor...
Abstract Background The complications of postoperative pain, such as hypertension, hypermetabolism, irritability, and cognitive dysfunction, significantly affect the rehabilitation elderly patients. Intrathecal morphine prolongs analgesia after surgery, but has been implicated in nausea vomiting, pruritus, respiratory depression, or apneic episodes. present study explored effect safety low-dose used adjunctively with bupivacaine during single spinal anesthesia sufentanil patient-controlled...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially emerging variants, poses an increased threat to global public health. The significant reduction in neutralization activity against the variants such as B.1.351 serum of convalescent patients and vaccinated people calls for design new potent vaccines targeting variant. However, since most approved clinical trials are based on sequence original SARS-CoV-2 strain, immunogenicity protective efficacy variant remain largely...
Background CD8+ cytotoxic T lymphocytes (CTLs) are crucial for eliminating hepatitis B virus (HBV) infected cells. DNA vaccination, a novel therapeutic strategy chronic infection, has been shown to induce CTL responses. However, accumulated data have that CTLs could not be effectively induced by HBV vaccination. Methodology/Principal Findings Here, we report praziquantel (PZQ), an anti-schistoma drug, act as adjuvant overcome the lack of potent responses vaccination in mice. PZQ combination...
Occupational and environmental exposure to uranium has been confirmed cause tissue injury carcinogenesis.
The association between selenium and peptide in gastric cancer is an important research topic. present study reported the facile synthesis of anticancer bioactive (ACBP)‑functionalized (ACBP‑S‑Se) particles with enhanced activities a detailed mechanistic evaluation their ability to regulate oxidative stress vitro. Structural chemical characterizations were revealed by ultraviolet absorption, Fourier transform infrared, X‑ray photoelectron, nuclear magnetic resonance carbon hydrogen, energy...
Breast cancer is the most frequent malignancy and leading cause of death among females. Long noncoding RNAs (lncRNAs) are under investigation as novel prognostic biomarkers in cancer. The aim study was to investigate expression, clinical implications significance lncRNA SPRY4-IT1, identify predictive value SPRY4-IT1 on outcome chemotherapy breast patients undergoing neoadjuvant (NACT). Bioinformatics indicated related chemo-resistance expression assessed by qRT-PCR tissues matched normal...
This study aimed to explore the characteristics of changes in sagittal arrangement spine between adolescent patients with idiopathic scoliosis (AIS) and normal adolescents, risk factors for AIS affecting progress AIS.X-ray images full length standing position were taken adolescents. Radiographic measurements made at intermediate follow-up included following:C1 C2 cervical lordosis - C7 curvature lordosis, C2-C7sagittal horizontal distance (C2-C7SagittalVerticalAxis, C2-C7SVA), TS-CL, after...
In this study, we evaluate the performance of enzyme‐linked immunosorbent assays (ELISAs) for HCV Ag detection in diagnosis and antiviral therapy management infections. For an active infection, limit corresponding to RNA level was approximately 7300 IU/mL; sensitivity, specificity, positive predictive value (PPV), negative (NPV) HCV‐Ag were 88.96, 100, 91.33%, respectively. The Pearson's correlation coefficient between 0.891. All patients with at interferon‐α2α/ribavirin week 1 achieved a...
Lumbar spine hyperosteogeny and ligament calcification are common in the elderly anesthesia puncture through conventional approach is difficult this age group, repeated can increase risk of spinal hematoma nerve injury. This study aimed to observe feasibility safety single administered with 25G needle lateral crypt for lower-extremity fracture surgery patients.The subjects were 60 patients our hospital (aged 65-80 years; ASA grades I II) scheduled (procedure was predicted last within 2 h)...
Abstract Background Neurodevelopmental disorders (NDD), such as autism spectrum (ASD) and intellectual (ID), are highly debilitating childhood psychiatric conditions. Genetic factors recognized playing a major role in NDD, with multitude of genes genomic regions implicated. While the functional validation NDD-associated has predominantly been carried out using mouse models, significant differences brain structure gene function between mice humans have limited effectiveness models exploring...