A5001571967- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Gastric Cancer Management and Outcomes
- Ultrasound and Hyperthermia Applications
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Photoacoustic and Ultrasonic Imaging
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Bacterial Infections and Vaccines
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Immune Cell Function and Interaction
- Immune cells in cancer
- Antimicrobial agents and applications
- Inflammasome and immune disorders
- Hernia repair and management
- Biochemical Acid Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Supramolecular Self-Assembly in Materials
- Clostridium difficile and Clostridium perfringens research
- Antioxidant Activity and Oxidative Stress
- Antioxidants, Aging, Portulaca oleracea
- Advanced Glycation End Products research
Air Force Medical University
2023-2024
Xijing Hospital
2022-2024
Fuzhou University
2023
Yantai Academy of Agricultural Sciences
2023
Guangxi Medical University
2021
Shenhua Group (China)
2020
Zhengzhou People's Hospital
2019
Renmin Hospital of Wuhan University
2017
Wuhan University
2017
Abstract Pyroptosis is a newly discovered inflammatory form of programmed cell death, which promotes systemic immune response in cancer immunotherapy. GSDMD one the key molecules executing pyroptosis, while therapeutical delivery to tumor cells great challenge. In this study, an extracellular vesicles‐based GSDMD‐N mRNA system (namely EV Tx ) developed for enhanced immunotherapy, with encapsulated inside, Ce6 (Chlorin e6 (Ce6), hydrophilic sensitizer) incorporated into vesicular membrane,...
Abstract Immunotherapy holds great promise for the treatment of malignant cancer. However, lack sufficient tumor neoantigens and incomplete dendritic cell (DC) maturation compromise efficacy immunotherapy. Here, a modular hydrogel‐based vaccine capable eliciting powerful sustained immune response is developed. Briefly, CCL21a Exo GM‐CSF+Ce6 (tumor cell‐derived exosomes with granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) mRNA encapsulated inside sonosensitizer chlorin e6 (Ce6)...
A fully synthetic self-adjuvanting cancer vaccine candidate was constructed through covalent conjugation of invariant natural killer T (iNKT) cell ligand α-galactosylceramide (αGalCer) with sialyl Tn (STn), a representative tumor-associated carbohydrate antigen (TACA). This two-component STn-αGalCer is devoid antigenic peptide, featuring the well-defined structure high simplicity. showed remarkable efficacy in inducing antibody class switching from IgM to STn-specific IgG. Subtypes IgG were...
Cancer vaccine has been considered as a promising immunotherapy by inducing specific anti-tumor immune response. Rational vaccination at suitable time to efficiently present tumor associated antigen will boost immunity and is badly needed. Here, poly (lactic-co-glycolic acid) (PLGA)-based cancer of nanoscale designed, in which engineered cell membrane proteins, mRNAs, sonosensitizer chlorin e6 (Ce6) are encapsulated high efficiency. The nanosized can be delivered into presentation cells...
Extracellular vesicle (EV)-based low-density lipoprotein receptor (
PDL1 blockade therapy holds great promise in cancer immunotherapy. Ultrasound imaging of expression the tumor is importance predicting therapeutic efficacy. As a proof-of-concept study, novel ultrasound contrast agent has been innovated here to image and block tissue. Briefly, extracellular vesicles (EVs) are engineered display truncated PD1 (tPD1) on surface bind with high affinity by fusion EV-abundant transmembrane protein PTGFRN. The EVs then encapsulated Ca(HCO
Tumor-draining lymph nodes (TDLNs) are the primary sites to initiate immune responses against cancer, as well origin of metastasis for most breast cancer cases. Reverting immunosuppression microenvironment in TDLNs is critical improving outcome malignancy, though still a big technical challenge. In this study, type smart exosomes was developed which exosome surface functionally engineered with CD62L (L-selectin, gene lymphocyte homing nodes) and OX40L (CD134L, effector T cell expansion...
Abstract Increased expression of immune check point genes, such as PD‐L1, is one the main reasons for immunosuppression, especially colon cancer. Development novel therapeutic strategies great importance to improve prognosis. In this study, outer membrane vesicles (OMV) derived from Gram‐negative bacteria are engineered checkpoint blockade nanosystem efficient elicitation anti‐tumor immunity. Briefly, OMVs with Lyp1‐Traptavidin (S52G, R53D mutant streptavidin) fusion protein displayed on...
Abstract Unravelling the mechanisms for immunosuppressive tumor microenvironment and developing corresponding therapeutic strategies are of great importance to improve cancer immunotherapy. This study has revealed that there abundant senescent cells accumulated in colon tissue, which contributes greatly microenvironment. Oral delivery Dasatinib Quercetin (D+Q) eliminates with compromised efficiency due poor penetration short half‐life. To efficacy cell clearance, this work developed an...
Abstract Accurately evaluating tumor neoangiogenesis and conducting precise interventions toward an immune‐favorable microenvironment are of significant clinical importance. In this study, a novel nanodroplet termed as the nanodroplet‐based ultrasound contrast agent therapeutic (NDs UCA/Tx ) is designed for imaging neoangiogenesis. Briefly, NDs shell constructed from engineered CMs containing antigen, vascular endothelial growth factor receptor 1 (VEGFR1) extracellular domain 2–3, CD93...
The aim of the present study was to investigate effect fecal microbiota transplantation (FMT) on acute inflammatory response in a murine model dextran sulfate sodium (DSS)‑induced colitis, and delineate putative underlying mechanism(s). Mice were divided into four groups, namely normal control, DSS, 5‑aminosalicylic acid (5‑ASA) FMT group. 5‑ASA groups orally administered 3% DSS (w/v) solution for 7 days induce colitis. On 1, 3, 5 7, mice respectively 0.5% carboxymethylcellulose sodium,...
The chelation of zinc to adjacent keto and phenoxy position was critical for enhancing rutin flavonoids' inhibition PDI, which provides a new strategy the clinical translation flavonoids.
Engineered Extracellular Vesicles In article number 2204031, Jing Zhao, Guodong Yang, Angang and co-workers develop an extracellular vesicle-based GSDMD-N mRNA delivery system (EVTx), in which is encapsulated inside the vesicle, HER2 antibody displayed on surface, sonosensitizer Ce6 incorporated into membrane. When endocytosed by HER2+ cancer cells, EVTx efficiently induces pyroptosis thus enhances immunotherapy.
Inhibition of aging vascular endothelial cells (VECs) may delay and prolong life. The goal this study was to prepare anti-CD31 monoclonal antibody conjugated PEG-modified liposomes containing the AU-rich region connecting factor 1 (AUF1) gene (CD31-PILs-AUF1) explore effects targeting CD31-PILs-AUF1 VECs.The mean particle sizes various PEGylated immunoliposomes (PILs) were measured using a Zetasizer Nano ZS. Gel retardation assay used confirm whether PILs had encapsulated AUF1 plasmid...
Total laparoscopic total gastrectomy (TLTG) for gastric cancer, especially with overlap esophagojejunostomy, has been verified that it advantages of minimally invasion, less intraoperative bleeding, and faster recovery. Meanwhile, early oral feeding (EOF) after the operation demonstrated to significantly promote rehabilitation in patients, particularly distal gastrectomy. However, due limited application TLTG, there is few related research proving whether credible or safe adopt EOF TLTG...
Objective: In this study, we aimed to compare the short-term safety of two digestive tract reconstruction techniques, laparoscopic total abdominal overlap anastomosis and laparoscopic-assisted end-to-side anastomosis, following radical resection Siewert Type II adenocarcinoma esophagogastric junction. Methods: retrospective cohort analyzed relevant clinical data 139 patients who had undergone surgery for junction adenocarcinoma. These included 89 treated at First Affiliated Hospital Air...
Immunotherapy involving PDL1 degradation holds great potential in anti-tumor treatment. Optimal design of degraders and subsequent efficient delivery into tumors are essential for expected efficacy, especially when abnormal tumor vasculature is considered. Herein, a nanodroplet-based novel drug platform termed as NDs
Background Siewert type II adenocarcinoma of the esophagogastric junction (Siewert AEG) can be resected by right thoracoabdominal surgical approach (RTA) or abdominal-transhiatal (TH) under minimally invasive conditions. Although both methods achieve complete tumor resection, there is a debate as to whether former method superior at least noninferior latter in terms safety. Currently, small number retrospective studies have compared two approaches, with inconclusive results. As such,...
Double direct seeding of cotton (with wheat or rapeseed) is a new method for cotton-growing regions in the Yangtze River Basin to adapt development mechanization. It would help reduce manual labor, optimize amount nitrogen fertilizer be used, physical and chemical production costs, improve benefits fields. We selected five counties from major cotton-producing areas Hubei Province three consecutive seasons, winter 2020 spring 2022. The experimental sites used no tillage with straw returning...