A5100753927- Sarcoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Gout, Hyperuricemia, Uric Acid
- Acute Ischemic Stroke Management
- TGF-β signaling in diseases
- Neuroscience and Neuropharmacology Research
- Spine and Intervertebral Disc Pathology
- Protein Kinase Regulation and GTPase Signaling
- Musculoskeletal pain and rehabilitation
- Cellular Mechanics and Interactions
- RNA modifications and cancer
- Neurological Disease Mechanisms and Treatments
- Radiopharmaceutical Chemistry and Applications
- Cell death mechanisms and regulation
- Chemokine receptors and signaling
- Medical Imaging and Analysis
- Circular RNAs in diseases
- Spinal Fractures and Fixation Techniques
- Oral and Maxillofacial Pathology
- Case Reports on Hematomas
- RNA Interference and Gene Delivery
- Protein Degradation and Inhibitors
- Polysaccharides and Plant Cell Walls
- Receptor Mechanisms and Signaling
- Orthopedic Infections and Treatments
Sichuan Agricultural University
2024
Guangxi Medical University
2013-2022
Capital Medical University
2011-2020
Beijing Shijitan Hospital
2011-2020
Peking University
2020
First Affiliated Hospital of GuangXi Medical University
2013-2019
Abstract Although a promising strategy, the mesenchymal stem cell (MSC)-based therapy of cartilage defects is sometimes accompanied with chronic inflammation during remodeling status, which may hinder regeneration. During this process, inflammatory cytokine tumor necrosis factor α (TNFα) plays an important role and be potential target. In study, we investigated effect Tnfα RNA interference by introducing functional highly safe carbon dot (CD)-SMCC nanovector synthesized bioconjugation CDs...
Osteosarcoma is a life-threatening malignancy that often occurs in teenagers. Collagen type I alpha 1 (COL1A1) polymorphism reportedly associated with the occurrence of several human diseases. However, relationship between COL1A1 and osteosarcoma remains unknown, there no report about prevalence osteosarcoma. The purpose this study to investigate associations susceptibility survival relative risk develop osteosarcomas overall were investigated homogeneous group 189 patients. Correlations...
Abstract Intervertebral disc degeneration (IDD) is among the most common spinal disorders, pathologically characterized by excessive cell apoptosis and production of proinflammatory factors. Pharmacological targeting nucleus pulposus (NP) may hold promise in IDD therapy, but it limited adverse side effects nonspecificity drugs. In this study, we used a natural compound, andrographolide (ANDRO), which has been widely to intervene inflammatory apoptotic diseases investigation NP based on...
Abstract Asparagus is a nutritionally dense stem vegetable whose growth and development are correlated with its quality yield. To investigate the dynamic changes underlying mechanisms during elongation process of asparagus stems, we documented pattern selected segments from four consecutive stages using physiological transcriptome analyses. Notably, rate accelerated at length 25 cm. A significant decrease in concentration sucrose, fructose, glucose, additional sugars was observed region...
Recent studies have suggested that G-protein-coupled receptor kinase 5 (GRK5) deficiency plays a significant role in the pathogenesis of early Alzheimer's disease. Mild soluble β-amyloid accumulation can result reduced membrane (functional) and elevated cytosolic levels GRK5. Dysfunction GRK5 impairs desensitization presynaptic muscarinic 2 (M2) autoreceptors, which results M2 hyperactivity inhibits acetylcholine (ACh) release. GRK dysfunction also promotes deleterious cycle further...
The Rho GTPase-activating protein 35 (ARHGAP35), an important family protein, may be associated with tumorigenesis of some tumors. Here, we investigated the relationship between polymorphic variant at 3′-UTR this gene (rs1052667) and osteosarcoma risk prognosis. This hospital-based case-control study, including 247 patients 428 age-, sex-, race-matched healthy controls, was conducted in Guangxi population. Genotypes were tested using TaqMan PCR technique. We found a significant difference...
Osteosarcoma is the most frequent malignant primary bone tumor. GRM4 expressed in human osteosarcoma cells, and high expression of mGluR4 tissues related to poor prognosis. The aim this study was investigate association between polymorphism gene susceptibility a Chinese population. In case-control study, we investigated polymorphisms (rs2229901, rs733457, rs1906953) with real-time quantitative polymerase chain reaction (PCR) assay (TaqMan). conducted 126 patients 168 subjects control group....
Background:Glutamate metabotropic receptor 4 (GRM4) has been correlated with the pathogenesis of osteosarcoma.The objective this study was to explore underlying molecular mechanism GRM4 in osteosarcoma. Material/Methods:The expression levels four human osteosarcoma cell lines and hFOB1.19 cells were examined by real-time quantitative PCR (RT-qPCR).The U2OS highest transfected lentivirus-mediated small interfering RNA (siRNA).The differentially expressed genes (DEGs) after gene silencing...
Glucocorticoid receptor DNA binding factor 1 (GRF-1) is an important Rho family GTPase-activating protein, and the dysregulation of GRF-1 expression maybe involved in tumor progression. However, role osteosarcoma prognosis has been well less elaborated. Here, we conducted a hospital-based case study, including 247 patients with pathologically confirmed to evaluate associations between prognosis. We found that high was correlated poor outcome compared low (the median recurrence-free survival...
Transforming growth factor (TGF)-β1 is the most abundant in human bone. Several polymorphisms have been described TGF-β1 gene. To explore correlation between gene single nucleotide polymorphism and clinicopathological characteristics of osteosarcoma. TaqMAN PCR technique was used to detect 124 patients with osteosarcoma from last follow-up 136 healthy controls. The difference gender, age, allele frequency patient group control χ 2 text were tested. relationship risk logistic regression...
Osteosarcoma (OS) is a malignant bone tumor common in children and adolescents. The 5-year survival rate only 67-69% there an urgent need to explore novel drugs effective for the OS. G protein-coupled receptors (GPCRs) are drug targets have been found be associated with OS, but seldom used OS.The GPCRs were obtained from GPCRdb, expression profile of OS was downloaded UCSC Xena platform including clinical data. 10-GPCRs model signatures related risk identified by analysis R software....