A5087424628- Cellular transport and secretion
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- Lipid Membrane Structure and Behavior
- Inflammatory mediators and NSAID effects
- Pancreatic function and diabetes
- Total Knee Arthroplasty Outcomes
- Cytokine Signaling Pathways and Interactions
- Shoulder Injury and Treatment
- Orthopedic Infections and Treatments
- Shoulder and Clavicle Injuries
- 3D Printing in Biomedical Research
- Liver physiology and pathology
- Renal and related cancers
- Apelin-related biomedical research
- Renal cell carcinoma treatment
- Protease and Inhibitor Mechanisms
- Retinal Development and Disorders
- Endoplasmic Reticulum Stress and Disease
- Sports injuries and prevention
- Renal and Vascular Pathologies
- Cell Adhesion Molecules Research
- Tissue Engineering and Regenerative Medicine
Guilin Medical University
2024
Shaoxing People's Hospital
2014-2024
Zhejiang University
2010-2023
Zhejiang University of Technology
2023
First Affiliated Hospital of GuangXi Medical University
2018-2021
Guangxi Medical University
2011-2021
University of Colorado Boulder
2014-2018
Affiliated Hospital of Guilin Medical College
2014
Georgia Regents Medical Center
2014
Augusta University
2014
Neuregulin 1 (NRG1) is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 multiple isoforms are generated by usage of different promoters alternative splicing single gene. However, little known about isoform composition profile, whether it changes during or the underlying mechanisms. We found each six types distinct expression pattern brain at ages, resulting change composition. In both human rat, most dominant III II, followed...
Diabetes is a metabolic disorder characterized by hyperglycemia. Insulin, which secreted pancreatic beta cells, recognized as the critical regulator of blood glucose, but molecular machinery responsible for insulin trafficking remains poorly defined. In particular, roles cytosolic factors that govern formation and maturation granules are unclear. Here we report PICK1 ICA69, two lipid-binding proteins, formed heteromeric BAR-domain complexes associated with at different stages their...
Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environment overexpressed matrix metalloproteinases-13 (MMP-13) are typical markers in osteoarthritis (OA), enables the development stimulus-responsive drug delivery system with high specificity OA. We herein demonstrate nano-micelle based stimuli-responsive theranostic strategy reporting release...
Stimulus-responsive therapy that allows precise imaging-guided is limited for osteoarthritis (OA) due to the selection of proper physiological markers as stimulus. Based on over-production Reactive Oxygen Species (ROS) associated with progression in OA, we selected ROS and designed a cartilage targeting ROS-responsive theranostic nanoprobe can be used effective bioimaging OA. This was fabricated by using PEG micelles modified ROS-sensitive thioketal linkers (TK) cartilage-targeting peptide,...
The fusion of neurotransmitter-filled synaptic vesicles with the plasma membrane requires two classes molecules—SNAP receptor (SNARE) and Sec1/Munc18 (SM) protein. Reconstitution studies suggest that SM protein Munc18-1 promotes zippering trans-SNARE complexes accelerates kinetics SNARE-dependent fusion. However, physiological role this trans-SNARE-regulating function in exocytosis remains to be established. Here we first demonstrate mutations vesicle-anchored v-SNARE selectively impair...
The purpose of the present study was to investigate underlying molecular mechanism osteoarthritis (OA) and rheumatoid arthritis (RA) based on microarray profiles. Three human joint fibroblast‐like synoviocytes (FLSs) profiles including 26 OA samples, 33 RA 20 healthy control (HC) samples were downloaded from GEO database. Differentially expressed genes (DEGs) between HC (DEGsOA) (DEGsRA) identified. Co‐expressed specific analysed DEGsOA DEGsRA. Gene ontology, KEGG pathway enrichment, PPI...
The trafficking of AMPA-type glutamate receptors to and from synapses is an important mechanism underlying synaptic plasticity, a cellular model learning memory. PICK1 (protein interacts with C-kinase 1) peripheral membrane protein that AMPA regulates their trafficking. contains PDZ (PSD-95/Dlg/ZO1) domain BAR (Bin/amphiphysin/Rvs) domain. the intracellular C-terminal tails receptors, while binds lipid membranes. Both receptor interaction binding are plasticity. Here, we identified ICA69...
Intracellular vesicle fusion is mediated by SNAREs and Sec1/Munc18 (SM) proteins. Despite intensive efforts, the SNARE-SM reaction has not been faithfully reconstituted in biochemical assays. Here, we present an unexpected discovery that macromolecular crowding required for reconstituting vitro. Macromolecular known to profoundly influence kinetic thermodynamic behaviors of macromolecules, but its role membrane transport processes such as remains unexplored. We introduced agents into...
Background/Aims: Current drug therapies for osteoarthritis (OA) are not practical because of the cytotoxicity and severe side-effects associated with most them. Artemisinin (ART), an antimalarial agent, is well known its safety selectivity to kill injured cells. Based on anti-inflammatory activity role in inhibition OA-associated Wnt/β-catenin signaling pathway, which crucial pathogenesis OA, we hypothesized that ART might have effect OA. Methods: The chondro-protective antiarthritic effects...
Introduction: Bladder cancer (BC) has a high incidence and mortality rate worldwide.Suppressor anaphasepromoting complex domain containing 2 (SAPCDC2) is over-expressed in variety of tumors.Objectives: This study investigated the effects SAPCD2 knockdown on BC cells.Methods: T24 UMUC3 cell models xenografted tumor model with were established to observe malignant phenotype cells by counting kit-8 assay, colony formation test, wound healing, Transwell mRNA proteins expressions measured...
Abstract Intervertebral disc degeneration (IDD) is among the most common spinal disorders, pathologically characterized by excessive cell apoptosis and production of proinflammatory factors. Pharmacological targeting nucleus pulposus (NP) may hold promise in IDD therapy, but it limited adverse side effects nonspecificity drugs. In this study, we used a natural compound, andrographolide (ANDRO), which has been widely to intervene inflammatory apoptotic diseases investigation NP based on...
In vitro expansion of mesenchymal stem cells (MSCs) has been implicated in loss multipotency, leading to impaired chondrogenic potential and an eventual therapeutic effect, as reported our previous study. However, the precise regulatory mechanism is still unclear. Here, we demonstrate that endoplasmic reticulum (ER) stress unfolded protein response (UPR) were involved transformation MSCs induced by culture based on comparative profiling cultured bone marrow at passage 3 (P3 BMSCs) vs. fresh...
Abstract In the context of severe burn injuries, presence excessive reactive oxygen species (ROS), prolonged microbial infection, and compromised angiogenesis can contribute to metabolic reprogramming macrophages, resulting in a dysregulated inflammatory response that hinders healing process. this study, cerium oxide nanoparticles (CeNPs) are encapsulated within silk fibroin‐poly(e‐caprolactone) polymer create an electrospun PSF/CeNPs nanofiber membrane (PSF/membrane). This is further...