A5023770920- Osteoarthritis Treatment and Mechanisms
- Cannabis and Cannabinoid Research
- Advanced Drug Delivery Systems
- Total Knee Arthroplasty Outcomes
- Inflammatory mediators and NSAID effects
- Curcumin's Biomedical Applications
- Paraquat toxicity studies and treatments
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemokine receptors and signaling
- Neurogenesis and neuroplasticity mechanisms
- Plant Stress Responses and Tolerance
- Ginger and Zingiberaceae research
- Nanoplatforms for cancer theranostics
- Orthopedic Infections and Treatments
- Parkinson's Disease Mechanisms and Treatments
First Affiliated Hospital of GuangXi Medical University
2021-2023
Guangxi Medical University
2021-2023
Fujian Medical University
2017-2020
Stimulus-responsive therapy that allows precise imaging-guided is limited for osteoarthritis (OA) due to the selection of proper physiological markers as stimulus. Based on over-production Reactive Oxygen Species (ROS) associated with progression in OA, we selected ROS and designed a cartilage targeting ROS-responsive theranostic nanoprobe can be used effective bioimaging OA. This was fabricated by using PEG micelles modified ROS-sensitive thioketal linkers (TK) cartilage-targeting peptide,...
Abstract Intra-articular (IA) injection is an efficient treatment for osteoarthritis, which will minimize systemic side effects. However, the joint experiences rapid clearance of therapeutics after intra-articular injection. Delivering system modified through active targeting strategies to facilitate localization within specific tissues such as cartilage hopeful increase therapeutic In this study, we designed a nanoscaled amphiphilic and cartilage-targeting polymer-drug delivery by using...
Abstract Cannabidiol (CBD) is a non‐intoxicating cannabinoid from cannabis sativa that has demonstrated efficacious against inflammation, which can be considered as potential drug for arthritis treatment. However, the poor solubility and low bioavailability limit its clinical application. Here, we report an effective strategy to fabricate Cannabidiol‐loaded poly(lactic‐co‐glycolic acid) copolymer (CBD‐PLGA) nanoparticles (NPs), with spherical morphology average diameter of 238 nm. CBD was...
Abstract Recent evidence indicates that microRNAs (miRNAs) play a key role in neurodegenerative diseases. However, the toxic effects of paraquat (PQ) and 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) on miRNA expression profiles dopaminergic neurons have not been investigated. In present study, we used microarray analysis to show PQ MPTP induce alterations neuro‐2a cells. The results reveal treatment with 300 μ m caused deregulation, such 60 miRNAs were upregulated 228 downregulated....
Abstract Laboratorial and epidemiological research has established a relationship between paraquat (PQ) exposure risk for Parkinson’s disease. Previously, we have investigated the effects of nuclear factor erythroid 2 related (Nrf2) microRNAs in PQ-induced neurotoxicity, addressing function miR-380-3p, microRNA dysregulated by PQ, as well Nrf2 deficiency. is known to mediate expression variety genes, including noncoding genes. By chromatin immunoprecipitation, identified miR-380-3p...
There is emerging evidence suggesting that oxidative stress and DNA methylation can alter miRNA expression. However, little known on the mechanism of miR-17-5p expression changes in paraquat (PQ)-induced nerve cell damage. In present study, neuro-2a cells were pretreated with antioxidant N-acetylcysteine (NAC) or inhibitor decitabine (DAC), then exposed to different concentrations PQ, while levels detected by qRT-PCR. Here, it showed PQ downregulated dose-dependently cells. The level was...
Abstract Cannabidiol (CBD) is a non-intoxicating cannabinoid from cannabis sativa that has demonstrated efficacious against inflammation, which can be considered as potential drug for arthritis treatment. However, the poor solubility and low bioavailability limit its clinical application. Here, we report an effective strategy to fabricate CBD-loaded poly lactic-co-glycolic acid nanoparticles (CBD-PLGA-NPs). The CBD-PLGA-NPs exhibited spherical morphology average diameter of 238 nm. CBD was...
Abstract Intra-articular (IA) injection is an efficient treatment for osteoarthritis. Such a will minimize systemic side effects and avoid the inconvenience of frequent injections. However, joint has poor bioavailability systemically administered drugs experiences rapid clearance therapeutics after intra-articular injection. Delivering system modified through active targeting strategies to facilitate localization within specific tissues such as cartilage hopeful increase therapeutic effects....
Abstract Stimulus-responsive therapy that allows precise imaging-guided is limited for osteoarthritis (OA) due to the selection of proper physiological markers as stimulus. Based on over-production Reactive Oxygen Species (ROS) one leading causes OA, we selected ROS and designed a cartilage-targeting ROS-responsive theranostic nanoprobe highly specific effective bioimaging OA. This was fabricated by using PEG micelles modified with ROS-sensitive thioketal linkers (TK) peptide, termed TKC,...