A5067031241- Cancer, Hypoxia, and Metabolism
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Adipose Tissue and Metabolism
- Cellular Mechanics and Interactions
- Birth, Development, and Health
- Force Microscopy Techniques and Applications
- Reproductive System and Pregnancy
- Nitric Oxide and Endothelin Effects
- Neurological Disease Mechanisms and Treatments
- Reproductive Physiology in Livestock
- Autophagy in Disease and Therapy
- Low-power high-performance VLSI design
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Cardiovascular Health and Disease Prevention
- Advanced Chemical Physics Studies
- Nerve injury and regeneration
- Sperm and Testicular Function
- Growth Hormone and Insulin-like Growth Factors
- Advancements in Semiconductor Devices and Circuit Design
- Pregnancy and preeclampsia studies
- Hydrocarbon exploration and reservoir analysis
- HIV/AIDS Research and Interventions
- Parallel Computing and Optimization Techniques
Fujian Normal University
2015-2024
Xi'an University of Architecture and Technology
2024
Xinjiang Academy of Agricultural and Reclamation Science
2020-2023
Bioscience (China)
2020
DuPont (China)
2020
Shanghai Jiao Tong University
2020
Xian Yang Central Hospital
2019
Hubei University of Medicine
2018
General Administration of Sport of China
2018
Tarim University
2018
Neuronal migration involves coordinated extension of the leading process and translocation soma, but relative contribution different subcellular regions, including cell rear, in driving soma remains unclear. By local manipulation cytoskeletal components restricted regions cultured neurons, we examined molecular machinery underlying generation traction force for during neuronal migration. In actively migrating cerebellar granule cells culture, a growth cone (GC)-like structure at tip exhibits...
Traction force against the substrate is required for neuronal migration, but how it generated and regulated remains controversial. Using traction microscopy, we showed in cultured granule cells coexistence of three distinct contraction centers (CCs) that are located at distal proximal regions leading process as well trailing process, exhibiting high-level myosin-II activities. The CC activities depended on myosin-II, actin filaments, microtubules, adhesion, exhibited apparently independent...
It is challenging to manage the thermal behavior of many-core microprocessors while still keeping them running at high performance since control complexity increases as core number increases. In this article, a novel hierarchical dynamic management method proposed overcome challenge. The new employs model predictive (MPC) with task migration and DVFS scheme ensure smooth negligible computing sacrifice. order be scalable systems, designed two levels. At lower level, cores are spatially...
During the luteinization after ovulation in mammalian ovary, containing cells undergo an energy consuming function re-determination process to differentiate into luteal under avascular environment. Previous evidences have delineated contribution of autophagy cell differentiation and catabolic homeostasis various types cells, whereas few interest had been focused on involvement granulosa during formation early corpus luteum. Herein, present study investigated that expression development...
Testes produce sperms, and gamete generation relies on a proper niche environment. The disruption of hierarchical regulatory homeostasis in Leydig or Sertoli cells may evoke sterile phenotype humans. In this study, we recapitulated type 2 diabetes mellitus by using high-fat diet- (HFD-) fed mouse model to identify the potential mechanism diabetes-induced testicular impairment. At end blood glucose levels, testosterone structure, antioxidant capacity, level expression hypoxia-inducible...
ABSTRACT Vascular endothelial growth factor (VEGF)‐dependent angiogenesis is crucial for corpus leteum formation and their functional maintenance in mammalian ovaries. The present study was designed to test the hypothesis that hypoxia‐inducible (HIF)‐1α‐mediated transcriptional activation contributes increased expression of VEGF gene response hypoxia bovine developing luteal cells (LCs). By real‐time RT‐PCR analysis, messenger RNA (mRNA) found significantly increase under or treatment with...
Endothelin (ET)-2 plays a crucial role in ovarian ovulation mammals. The present study was designed to test the hypothesis that hypoxia-inducible factor (HIF)-1α-mediated transcriptional activation contributes increased expression of ET-2 gene response hCG rat granulosa cells (GCs) during gonadotropin-induced superovulation. By real-time RT-PCR analysis, mRNA found significantly increase cultured GCs after treatment with hCG, or even N-carbobenzoxyl-L-leucinyl-L-leucinyl-L-norvalinal...
It is established that the physiological effects of insulin are primarily mediated by signaling pathway. However, a defective closely associated with clinical manifestations polycystic ovary syndrome (PCOS), which include excess androgen levels, resistance and anovulation, involved in pathophysiology PCOS at molecular level. Dimethyldiguanide (DMBG) has been widely employed to alleviate reproduction dysfunction women PCOS, however, exact mechanism this effect remains unclear. The objective...
The contribution of autophagy to catabolic balance has been well-established in various types cells, whereas the involvement progesterone synthesis during rat pregnancy still remains unknown. Therefore, present study was designed evaluate role production luteal development pregnant rats. results showed autophagy-related proteins maintained at a low level on day 10 after pregnancy, significantly induced 16 and subsided relative 21, which consistent with changes serum levels. findings further...
The mechanical properties of cells could serve as an indicator for disease progression and early cancer diagnosis. This study utilized atomic force microscopy (AFM) to measure the viscoelastic ovarian then examined association with invasion at level living single cells. Elasticity viscosity OVCAR-3 HO-8910 are significantly lower than those human surface epithelial cell (HOSEpiC) control. Further examination found a dramatic increase migration/invasion obvious decease microfilament density...
G protein–coupled receptor 3 (GPR3) is an orphan (GPCR) predominantly expressed in mammalian brain and oocytes. GPR3 plays important roles these two organs known as a G<i>α</i><sub>s</sub>-coupled receptor–activated constitutively cells. However, the signal transduction pathway pharmacological function of remain unclear because lack specific ligand. By use human embryonic kidney 293 cell line stably expressing FLAG-GPR3-green fluorescent protein, chemical screening for ligands was performed...
Owing to the avascular structure of ovarian follicle, proliferation granulosa cells (GCs) and development follicles occur under hypoxia, which is obviously different from cell survival requirements most mammalian cells. We hypothesized that autophagy may exert an inhibitory effect on GC apoptosis. To decipher underlying mechanism, we constructed a rat follicular model using pregnant mare serum gonadotropin culture experiment in hypoxic conditions (3% O 2 ). The present results showed level...
Obesity has a negative effect on ovarian functions, which is reported to increase the risk of infertility. The mechanism underlying obesity‑induced infertility not yet clear. present study established high‑fat diet (HFD)‑induced obesity mouse model elucidate mechanisms HFD‑induced follicular development in ovary. 4‑week‑old female mice were fed with HFD or normal control (NC) for 15 20 weeks. Body mass index was used demonstrate that obese following treatment. ovaries from group retarded...
Follicular development and following ovulation induced by luteinizing hormone (LH) surge are critical for ovarian functions, but the molecular mechanism regulating attracts more attention remains mainly unknown. Recent researches on nucleotide leukin rich polypeptide 3 (NLRP3) inflammasome shred light it. Given pregnant mare serum gonadotropin (PMSG) can not only trigger follicular development, also induce ovulation, present study therefore examined that expression localization of NLRP3...