A5067610322- Biomarkers in Disease Mechanisms
- CAR-T cell therapy research
- Hematological disorders and diagnostics
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Clusterin in disease pathology
- SARS-CoV-2 and COVID-19 Research
- Inflammatory Biomarkers in Disease Prognosis
- Monoclonal and Polyclonal Antibodies Research
- CRISPR and Genetic Engineering
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- HIV-related health complications and treatments
- MXene and MAX Phase Materials
- Acute Myeloid Leukemia Research
- Silicon Carbide Semiconductor Technologies
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Aluminum Alloys Composites Properties
- Immunotherapy and Immune Responses
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Neutropenia and Cancer Infections
Guangdong Provincial People's Hospital
2023-2025
Guangdong Academy of Medical Sciences
2023-2025
Southern Medical University
2023-2025
Sun Yat-sen University
2019-2024
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic and claimed over million lives worldwide. Although the genetic sequences of SARS-CoV SARS-CoV-2 have high homology, clinical pathological characteristics COVID-19 differ significantly from those SARS. How whether evades (cellular) immune surveillance requires further elucidation. In this study, we show that infection leads to major histocompability complex class Ι (MHC-Ι)...
Abstract The inhibitory receptors PD-1, Tim-3, and Lag-3 are highly expressed on tumor-infiltrating lymphocytes compromise their antitumor activity. For efficient cancer immunotherapy, it is important to prevent chimeric antigen receptor T (CAR-T)-cell exhaustion. Here we downregulate these three checkpoint simultaneously CAR-T cells that show the resulting PTL-CAR-T undergo epigenetic modifications better control tumor growth. Furthermore, unexpectedly find increased infiltration by...
BACKGROUND. Chimeric antigen receptor (CAR) T cells have emerged as an approach to treat malignant tumors. This strategy has also been proposed for the treatment of HIV-1 infection. We developed a broadly neutralizing antibody–derived (bNAb-derived) CAR cell therapy that can exert specific cytotoxic activity against HIV-1–infected cells.
Abstract Background Existing treatments for cholangiocarcinoma have poor efficacy. However, chimeric antigen receptor‐T (CAR‐T) cells are emerging as a potential therapeutic strategy. Solid tumors possess multiple adverse factors in an immunosuppressive microenvironment that impair CAR‐T cell infiltration and function. This study aimed to improve the function of through knock down immune checkpoints molecular receptors. Methods We evaluated expression epidermal growth factor receptor (EGFR)...
Chimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in the study of targeted therapy multiple tumor-associated antigens hepatocellular carcinoma (HCC). However, suppressive microenvironment and individual heterogeneity results downregulation these certain patients' cancer cells. Therefore, optimizing CAR-T for HCC is imperative.
Abstract Since the outbreak of coronavirus disease 2019 (COVID-19), it has become a global pandemic. The spike (S) protein etiologic severe acute respiratory syndrome 2 (SARS-CoV-2) specifically recognizes human angiotensin-converting enzyme (hACE2) as its receptor, which is recently identified an interferon (IFN)-stimulated gene. Here, we find that hACE2 exists on surface exosomes released by different cell types, and expression exosomal increased IFNα/β treatment. In particular, can block...
COVID-19 has caused a severe global pandemic. Until now, there been no simple and reliable system available in lower-biosafety-grade laboratory for SARS-CoV-2 virologic research inhibitor screening.
T cell lymphoma (TCL) is a highly heterogeneous group of diseases with poor prognosis and low 5-year overall survival rate. The current therapeutic regimens have relatively efficacy rates. Clinical studies single-target chimeric antigen receptor (CAR-T cell) therapy in lymphocytes require large multiple infusions, increasing the risks cost treatment; therefore, optimizing targeted way to improve prognosis. Despite significant advances bispecific CAR-T avoid escape treatment B lymphoma,...
Abstract Background Chimeric antigen receptor-T (CAR-T) cells therapy is one of the novel immunotherapeutic approaches with significant clinical success. However, their applications are limited because long preparation time, high cost, and interpersonal variations. Although manufacture universal CAR-T (U-CAR-T) have significantly improved, they still not a stable unified cell bank. Methods Here, we tried to further improve convenience flexibility U-CAR-T by constructing modular (MU-CAR-T)...
Abstract Background: Clonal hematopoiesis of indeterminate potential (CHIP) has been shown to be associated with the occurrence solid tumors, but its relationship colorectal cancer still needs studied. Methods: We conducted a prospective matched case-control study using data from UK Biobank, including 5,310 incident (CRC) cases and 26,550 controls for age, sex, body mass index (BMI). Results: Analysis Biobank revealed that presence CHIP was an increased risk CRC. The odds ratio (OR) CRC in...
<div>AbstractBackground:<p>Clonal hematopoiesis of indeterminate potential (CHIP) has been shown to be associated with the occurrence solid tumors, but its relationship colorectal cancer still needs studied.</p>Methods:<p>We conducted a prospective matched case–control study using data from UK Biobank, including 5,310 incident cases and 26,550 controls for age, sex, body mass index.</p>Results:<p>Analysis Biobank revealed that presence CHIP was an...
<p>Supplementary Figure S1: Overview of the study design. Flowchart showing selection population.</p>
Current combined antiretroviral therapy (cART) mainly targets 3 of the 15 HIV proteins leaving many potential viral vulnerabilities unexploited. To purge HIV-1 latent reservoir, various strategies including "shock and kill" have been developed. A key question is how to restore impaired immune surveillance. protein Nef has long known mediate downregulation cell-surface MHC-I assist evade system. Through high throughput screening Food Drug Administration (FDA) approved drugs, we identified...
The human immunodeficiency virus type 1 (HIV-1) reservoir consists of latently infected cells which present a major obstacle to achieving functional cure for HIV-1. formation and maintenance HIV-1 latency have been extensively studied, latency-reversing agents (LRAs) that can reactivate latent by targeting the involved host factors are developed; however, their clinical efficacies remain unsatisfactory. Therefore, it is imperative identify novel targets more potential candidates or better...
Background The failure of conventional therapies and the propensity for recurrence metastasis make triple-negative breast cancer (TNBC) a formidable challenge with grim prognoses diminished survival rates. Immunotherapy, including immune checkpoint blockade chimeric antigen receptor (CAR)-T cell therapy, presents innovative potentially more effective strategies addressing TNBC. Within this context, inducible costimulator (ICOS), member CTLA4/CD28 family, plays crucial role in regulating...
Human immunodeficiency virus type 1 (HIV-1) can integrate viral DNA into host cell chromosomes to establish a long-term stable latent reservoir, which is major obstacle cure HIV-1 infection. The characteristics of the reservoir have not been fully understood. Here, we identified 126 upregulated plasma membrane proteins in latently infected cells by label-free liquid chromatography-tandem mass spectrometry analysis. higher levels CD98 expression multiple lines and primary CD4+ T compared...
HIV-1 can integrate viral DNA into host cell chromosomes and establish a long-term stable latent reservoir, major obstacle in curing infection. The reactivation of proviruses with latency-reversing agents (LRAs) is prerequisite for the eradication reservoirs. Previous reports have shown that tannic acid (TA) exerts several biological functions, including antioxidant antitumor activities. Here, we identified novel function TA as reactivator latency. showed similar features to transactivator...