A5018396033- Catalysis for Biomass Conversion
- HIV Research and Treatment
- Hepatitis C virus research
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Synthesis and Characterization of Pyrroles
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- HIV/AIDS Research and Interventions
- Catalytic Processes in Materials Science
- Catalysis and Oxidation Reactions
- Catalysis and Hydrodesulfurization Studies
- Medical Research and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Plant Pathogens and Fungal Diseases
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Inflammasome and immune disorders
- Fungal and yeast genetics research
- Systemic Lupus Erythematosus Research
- Fungal Biology and Applications
Shihezi University
2022-2024
Guangzhou Eighth People's Hospital
2009-2023
Guangzhou Medical University
2016-2023
Xinjiang Production and Construction Corps
2022
BACKGROUND. Chimeric antigen receptor (CAR) T cells have emerged as an approach to treat malignant tumors. This strategy has also been proposed for the treatment of HIV-1 infection. We developed a broadly neutralizing antibody–derived (bNAb-derived) CAR cell therapy that can exert specific cytotoxic activity against HIV-1–infected cells.
Although the outbreak of human immunodeficiency virus type 1 (HIV-1) in Guangdong has been documented for more than a decade, molecular characteristics such regional HIV-1 epidemic remained unknown.By sequencing pol/env genes and phylogenetic analysis, we performed epidemiologic study representative subset (n = 200) 508 HIV-1-seropositive individuals followed up at center HIV/AIDS care treatment Guangzhou Hospital Infectious Diseases. Of 157 samples (54.1% heterosexual acquired adults, 20.4%...
We examined the safety and efficacy of human umbilical cord mesenchymal stem cell (hUC-MSC) infusion for immune non-responder (INR) patients with chronic HIV-1 infection, who represent an unmet medical need even in era efficient antiretroviral therapy (ART). Seventy-two INR HIV were enrolled this phase II randomized, double-blinded, multicenter, placebo-controlled, dose-determination trial (NCT01213186) from May 2013 to March 2016. They assigned receive high-dose (1.5 × 10
Phospholipase B is a virulence factor for several clinically important pathogenic fungi, including Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, but its role in the thermally dimorphic fungus Talaromyces marneffei remains unclear. Here, we provide first report of expression novel phospholipase gene, designated TmPlb1, from T. eukaryotic system Pichia pastoris GS115. Sensitive real-time quantitative reverse-transcription PCR (qRT-PCR) demonstrated that TmPlb1 increased...
Background Talaromycosis (TM) caused by Talaromyces marneffei ( T. ) is a growing public health concern. Although Toll-like receptor (TLR) genes play critical role in the host defense against fungal infection, influence of polymorphisms these on susceptibility acquired immune deficiency syndrome (AIDS) patients to TM remains unknown. This study aims uncover associations single nucleotide (SNPs) TLR with among AIDS. Methods Altogether 200 AIDS complicated TM, matched without and 76 healthy...
Objectives This study aimed to investigate the influencing factors of delayed clearance Talaromyces marneffei ( T . ) in blood culture patients with acquired immune deficiency syndrome (AIDS) complicated talaromycosis after antifungal therapy. Methods The AIDS were retrospectively enrolled, and divided into two groups according results weeks baseline clinical data collected susceptibility was tested. Results A total 190 whom 101 cases remained positive for (Pos-group) while other 89 negative...
Abstract We studied the characteristics of immune activation and investigated underlying mechanisms in patients with human immunodeficiency virus‐1/hepatitis B virus (HIV/HBV) coinfection after receiving HBV‐active antiretroviral therapy. Forty HIV/HBV coinfection, 38 HIV monoinfection 20 healthy controls were enrolled. CD4 + count, load, HBV markers regulatory T‐cell (Treg cell) frequency assessed compared between HIV‐monoinfected HIV/HBV‐coinfected at week 0 (baseline), 12, 24, 36 48 onset...
Background: Although the outbreak of human immunodeficiency virus type 1 (HIV-1) in Guangdong has been documented for more than a decade, molecular characteristics such regional HIV-1 epidemic remained unknown.Methodology/Principal Findings: By sequencing pol/env genes and phylogenetic analysis, we performed epidemiologic study representative subset (n = 200) 508 HIV-1-seropositive individuals followed up at center HIV/AIDS care treatment Guangzhou Hospital Infectious Diseases.Of 157 samples...
Mercuric chloride catalysts are used to catalyze acetylene hydration for acetaldehyde production with high activity, but toxicity limits its practical application. Here we present a phosphorus and sulfur ligands-complexed copper catalyst assessed hydration. The optimum gave more than 94.0% conversion 88.4% aldehyde selectivity at 10 h. After running 20 h, the showed stability. remained stable over 93.3% of decreased from 92.2% 79.7%. accession could be highly vigorous reaction. results...
Dimerization of acetylene to monovinylacetylene (MVA) is a vital process for producing chloroprene rubber in the industry and highly attractive challenging. To study influence ligands on catalytic performance Cu-based catalyst mechanism gas–solid dimerization reaction, modified with N,N-dimethylformamide (DMF) was prepared via an incipient wetness method, which increased average MVA yield by 50% compared Cu/AC catalysts. X-ray photoelectron spectroscopy, absorption fine structure hydrogen...
This randomised controlled, open-label, non-inferiority trial was conducted in antiretroviral-naïve HIV-1-infected patients to assess the efficacy and safety of 48-week dual therapy LPV/r plus 3TC (DT group) compared with Chinese first-line triple-therapy regimen (TT group).198 were DT (n = 100) or TT 98).Ninety-two (92%) 88 (89.8%) achieved HIV-1 RNA <50 copies/ml at week 48 (P 0.629). Moreover, profile similar between two groups, no secondary HIV resistance observed.The results suggest...
Abstract Biomarkers of monocyte‐macrophages activation and inflammation in plasma such as interleukin‐18 (IL‐18), soluble leukocyte differentiation antigen 14 (sCD14), sCD163 are associated with disease severity prognosis HIV‐1 infected patients, however, their relationships efficacy antiretroviral therapy (ART) need further investigation. We aimed to characterize explore the clinical significance IL‐18, sCD14, this population. This was a retrospective cohort study consisting patients...
Linghua Liab, Fengyu Hub, Wanshan Chenb, Xiaoping Tang*ab, Weinan Songb, Yangling Kuangb, Weiping Caib & Xiejie Chenba Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Chinab Institute for Guangzhou No.8 People's China
Background: Although the outbreak of human immunodeficiency virus type 1 (HIV-1) in Guangdong has been documented for more than a decade, molecular characteristics such regional HIV-1 epidemic remained unknown.Methodology/Principal Findings: By sequencing pol/env genes and phylogenetic analysis, we performed epidemiologic study representative subset (n = 200) 508 HIV-1-seropositive individuals followed up at center HIV/AIDS care treatment Guangzhou Hospital Infectious Diseases.Of 157 samples...
Chronic liver disease has emerged as a leading cause of non-acquired immune deficiency syndrome (AIDS)-related mortality in hepatitis C virus (HCV)/human immunodeficiency (HIV)-coinfected patients. The relationship between CD4 cell count and HIV-related opportunistic infections tumors been well characterized; however, it is unclear whether associated with HCV-related hepatic events.