Journal Article Clinical trials of artemisinin and its derivatives in the treatment malaria China Get access Guo-Qiao Li, Li Sanya Tropical Medicine Institute, Guangzhou College Traditional Chinese Medicine, Guangzhou, People's Republic Search for other works by this author on: Oxford Academic PubMed Google Scholar Xing-Bo Guo, Guo Lin-Chun Fu, Fu Hua-Xiang Jian, Jian Xin-Hua Wang Transactions The Royal Society Hygiene, Volume 88, Issue Supplement_1, June 1994, Pages 5–6,...

The use of chloroquine treatment for Plasmodium falciparum malaria was abandoned in China 1979 because widespread drug resistance. Subsequent studies found decreases the prevalence chloroquine-resistant strains. To evaluate these and assess current status sensitivity Hainan, China, we determined P. resistance transporter (PfCRT) 76T marker DNA blood samples collected from 1978 to 2001. Results showed presence PfCRT 101 112 (90%) 1981, 30 43 (70%) 1986, 22 34 (65%) 1997 1998, 37 68 (54%) thus...

Slow transit constipation (STC) has become an epidemic medical problem. There are several kinds of drugs for constipation; however, each drug its limitations. The gut microbiota a close relationship with STC. Lactulose is effective because it kind bulking laxative and microbioecologic, relieves the syndromes We found that Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweet almond, semen sesami nigrum, hemp seed, similar effect on...

Dihydroartemisinin (DHA) is a derivative of artemisinin and an effective anti-malaria therapeutic used worldwide. In this report, we report that DHA as potential anti-cancer drug for prostate cancer. Our data indicate suppresses the PI3-K/Akt ERK cell survival pathways triggers induction death receptor DR5 activation extrinsic intrinsic signaling. DHA-mediated appears to occur via increased transcriptional activity promoter. also show that, while has strong cytotocixity in tumor cells, it...

3'-Deoxy-4-O-methylepisappanol, a new 3-benzylchroman derivative, was isolated from Sappan Lignum, together with thirteen known chemical compounds identified as protosappanin A, sappanchalcone, sappanone B, palmitic acid, (+)-(8S,8'S)-bisdihydrosiringenin, brazilein, 3-deoxysappanchalcone, (+)-lyoniresinol, 3-deoxysappanone isoprotosappanin 3'-O-methylbrazilin and brazilin, respectively. Among these compounds, this is the first time that (+)-(8S,8'S)-bisdihydrosiringenin obtained family...

Mechanism through which psyllium husk and orlistat lower cholesterol LPS.

SummaryEfforts to develop a vaccine against HIV have so far met with limited success. Given that CD4+ T cell activation drives the initial burst of viral replication, we explored in macaques whether an oral comprised Lactobacillus plantarum, commensal bacterium favors immune tolerance, and inactivated simian immunodeficiency virus mac239 (SIVmac239) would induce unresponsiveness/tolerance toward SIV antigens thereby prevent establishment infection. The tolerogenic induced MHC-Ib/E-restricted...

Tenacissimoside A (1) and 11α-O-benzoyl-12β-O-acetyltenacigenin B (2), two derivatives of tenacigenin (3) from the plant Marsdenia tenacissima, reversed multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells. The sensitivity HepG2/Dox cells to antitumor drugs doxorubicin, vinblastine, puromycin, paclitexel was increased by 18-, 10-, 11-, 6-fold 20 μg/mL (or 25 µM) 1 16-, 53-, 326-fold 39 2, respectively. preliminary mechanistic study has suggested that...

Background We have previously reported in Xishuangbanna (Banna) Dai Autonomous Prefecture, a well-developed tourist destination the southwest border of China, that HIV-1 transmitted dominantly through heterosexual contact with less divergent genotypes and few drug resistant mutations [1]. Due to rapid increase newly diagnosed cases per year Banna recent years, it's important evaluate evolution molecular epidemiology for better understanding ongoing outbreak this region. Methodology/Principal...

We previously demonstrated in the Chinese macaque model that an oral vaccine made of inactivated SIV and Lactobacillus plantarum induced CD8(+) regulatory T-cells, which suppressed activation SIV(+)CD4(+) prevented replication, protected macaques from challenges. Here, we sought whether a similar population T-regs would induce suppression HIV replication elite controllers (ECs), small (3‰) HIV-infected patients with undetectable replication. For purpose, investigated vitro antiviral activity...

It is need for development of new means against influenza virus due to the lack efficacy available therapeutic strategies. In previous research, 1,8‐cineol exert its inhibition nuclear factor (NF)‐κB, main regulator cytokine and chemokine production in influenza, anti‐inflammatory activity. These fact supports helps establish hypothesis that may have synergism with an antiviral on infection. The combined effect oseltamivir a mouse type A (Victoria/3/75,H3N2) model were examined. We initially...

Background Although Chinese-origin Rhesus macaques (Ch RhMs) infected with simian immunodeficiency virus (SIV) have been used for many years to evaluate the efficacy of AIDS vaccines and therapeutics, bio-clinical variability such a nonhuman primate model was so far not established. Methodology/Principal Findings By randomizing 150 (78 male 72 female) Ch RhMs diverse MHC class I alleles into 3 groups (50 animals per group) challenged intrarectal (ir) SIVmac239, intravenous (iv) or iv...

6α-Hydroxylup-20(29)-en-3-on-28-oic acid (1), a natural triterpenoid, was found to possess the ability in dose-dependent manner inhibiting hormone-induced adipocyte differentiation 3T3-L1 preadipocytes, and restoring glucose consuming dexamethasone (DXM)-induced insulin resistant adipocytes. Compound 1 also ameliorate DXM-induced dysfunction lipolysis adipokine secretion. Mechanistic studies revealed that inhibited preadipocytes via down-regulating hormone-stimulated gene transcription of...

Cajanolactone A (CLA) is a stilbenoid discovered by us from Cajanus cajan (L.) Millsp. In our study, CLA was found to promote osteoblast differentiation in human bone marrow mesenchymal stem cells (hBMSCs), as judged increased cellular alkaline phosphatase activity and extracellular calcium deposits, elevated protein expression of Runx2, collagen-1, morphogenetic protein-2, osteopontin. Mechanistic studies revealed that hBMSCs undergoing expressed upregulated mRNA levels Wnt3a, Wnt10b,...

Journal Article Antioxidant vitamins in acute malaria Get access T.M.E. Davis, Davis ∗ 1University of Western Australia Department Medicine, Fremantle Hospital, P.O. Box 480, Fremantle, WA 6160, ∗Author for correspondence and offprint requests. Search other works by this author on: Oxford Academic PubMed Google Scholar P. Garcia-Webb, Garcia-Webb 2Department Biochemistry, Sir Charles Gairdner Nedlands, 6009, Lin-Chun Fu, Fu 3Sanya Tropical Medicine Institute, Guangzhou College Traditional...

Aikeqing (AKQ) has been shown in clinical studies to improve quality of life HIV/AIDS patients, but anti-HIV activity not determined. The SHIV-infected macaque is an important animal model for testing antiviral drugs. This study aimed determine the AKQ chronically SHIV89.6-infected Chinese rhesus macaques.Nine macaques were inoculated intravenously with SHIV89.6 virus. At 11 weeks post-infection, animals arbitrarily divided into three groups: high-dose (AKQ 1.65 g/kg; n = 3), low-dose 0.55...

Abnormally increased immune activation is one of the main pathological features acquired immunodeficiency syndrome (AIDS). This study aimed to determine whether long-term nonprogression (LTNP) suppresses upregulation and elucidate mechanisms whereby LTNP state maintained.For this we selected 4 rhesus macaques(RMs) infected with simian virus (SIV) that were nonprogressors (LTNP); for comparison chose healthy RMs seronegative SIV (hereafter referred as Control group), progressing infection...

Journal Article Double-blind dose finding study of mefloquine-sulfadoxine-pyrimethamine in children with acute falciparum malaria Get access X.B. Guo, Guo 1Malaria Research Unit, Guangzhou College Traditional Chinese Medicine, Guangzhou, Guangdong, People's Republic China Search for other works by this author on: Oxford Academic PubMed Google Scholar K. Arnold, Arnold ∗ 2Roche Asian Foundation, P.O. Box 98595, Tsimshatsui, Hong Kong ∗Author correspondence. L.C. Fu, Fu P.Q. Chen, Chen G.Q. Li...

Background: Although the outbreak of human immunodeficiency virus type 1 (HIV-1) in Guangdong has been documented for more than a decade, molecular characteristics such regional HIV-1 epidemic remained unknown.Methodology/Principal Findings: By sequencing pol/env genes and phylogenetic analysis, we performed epidemiologic study representative subset (n = 200) 508 HIV-1-seropositive individuals followed up at center HIV/AIDS care treatment Guangzhou Hospital Infectious Diseases.Of 157 samples...