A5101901822- Mosquito-borne diseases and control
- Heart Failure Treatment and Management
- HIV Research and Treatment
- Cardiac Health and Mental Health
- Radiomics and Machine Learning in Medical Imaging
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- CAR-T cell therapy research
- Animal Virus Infections Studies
- HIV/AIDS Research and Interventions
- Job Satisfaction and Organizational Behavior
- Medication Adherence and Compliance
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 and Mental Health
- Immune Cell Function and Interaction
- Radioactivity and Radon Measurements
- Respiratory viral infections research
- Renal cell carcinoma treatment
- HIV/AIDS drug development and treatment
- Virus-based gene therapy research
- Innovation and Socioeconomic Development
- Digital Mental Health Interventions
- Perfectionism, Procrastination, Anxiety Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- GDF15 and Related Biomarkers
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Sun Yat-sen University
2015-2024
Zhengzhou University
2023-2024
Henan Provincial People's Hospital
2024
InferVision (China)
2022-2024
Digital China Health (China)
2024
Huashan Hospital
2020-2022
Shanghai Public Health Clinical Center
2020-2022
Shandong University
2019-2022
Hefei University
2022
Despite the advent of combined antiretroviral therapy (cART), persistence viral reservoirs remains a major barrier to curing human immunodeficiency virus type 1 (HIV-1) infection. Recently, shock and kill strategy, by which such are eradicated following reactivation latent HIV-1 latency-reversing agents (LRAs), has been extensively practiced. It is important reestablish virus-specific reliable immune surveillance eradicate reactivated virus-harboring cells. In this report, we attempted reach...
Abstract Cytoskeleton is extensively recruited by flaviviruses for their infection. In this study, we uncovered an essential role of a nuclear membrane protein, SAD1/UNC84 domain protein 2 (SUN2) linking cytoskeleton and nucleoskeleton in the flavivirus replication. CRISPR/Cas9-mediated knockout SUN2, but not SUN1, significantly reduces replication Zika virus (ZIKV), dengue (DENV), Japanese encephalitis (JEV). contrast, SUN2 does affect infection non-flaviviridae RNA viruses. All three...
Heterologous boost vaccination has been proposed as an option to elicit stronger and broader, or longer-lasting immunity. We assessed the safety immunogenicity of heterologous immunization with a recombinant adenovirus type-5-vectored Coronavirus Disease 2019 (COVID-19) vaccine (Convidecia, hereafter referred CV) protein-subunit-based COVID-19 (ZF2001, ZF). conducted randomized, observer-blinded, placebo-controlled trial, in which healthy adults aged 18 years older, who have received 1 dose...
Abstract Background To establish a predictive model based on multisequence magnetic resonance imaging (MRI) using deep learning to identify wild-type (WT) epidermal growth factor receptor (EGFR), EGFR exon 19 deletion (19Del), and 21-point mutation (21L858R) simultaneously. Methods A total of 399 patients with proven brain metastases non-small cell lung cancer (NSCLC) were retrospectively enrolled divided into training ( n = 306) testing 93) cohorts separately two timepoints. All underwent...
Chimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in the study of targeted therapy multiple tumor-associated antigens hepatocellular carcinoma (HCC). However, suppressive microenvironment and individual heterogeneity results downregulation these certain patients' cancer cells. Therefore, optimizing CAR-T for HCC is imperative.
Zika virus (ZIKV) is genetically and biologically related to other Flaviviridae family members has disseminated many countries. It associated with severe consequences, including the abnormal development of neural system in fetuses neurological diseases adults. Therefore, anti-ZIKV drugs paramount importance. Screening generic revealed that several nonsteroidal anti-inflammatory (NSAIDs), aspirin, ibuprofen, naproxen, acetaminophen, lornoxicam, potently inhibited entry Env/HIV-1-pseudotyped...
T cell lymphoma (TCL) is a highly heterogeneous group of diseases with poor prognosis and low 5-year overall survival rate. The current therapeutic regimens have relatively efficacy rates. Clinical studies single-target chimeric antigen receptor (CAR-T cell) therapy in lymphocytes require large multiple infusions, increasing the risks cost treatment; therefore, optimizing targeted way to improve prognosis. Despite significant advances bispecific CAR-T avoid escape treatment B lymphoma,...
Previous investigators have demonstrated that uncertainty in illness is associated with quality of life (QoL) patients chronic illness. However, little known about the mechanism underlying relationship heart failure.The aim this study was to examine multiple mediating effects perceived stress and coping strategies on between QoL failure.We conducted a cross-sectional 302 failure recruited at general hospital China from October 2016 September 2017. Uncertainty illness, stress, strategies,...
In nursing care organizations, nurses' social networks affect their behavior and play an important role in practice. This study aimed to explore the relationships among network degree centrality, job satisfaction, work engagement organizational citizenship (OCB) nurses.A cross-sectional survey design (one-on-one investigation) was used. The conducted 254 nurses working 10 units two hospitals China from November 2019-February 2020. participants completed a paper questionnaire that measured...
Although combined antiretroviral therapy (cART) successfully decreases plasma viremia to undetectable levels, the complete eradication of human immunodeficiency virus type 1 (HIV-1) remains impractical because existence a viral reservoir, mainly in resting memory CD4+ T cells. Various cytokines, protein kinase C activators, and histone deacetylase inhibitors (HDACi) have been used as latency-reversing agents (LRAs), but their unacceptable side effects or low efficiencies limit clinical use....
Long non-coding RNAs (lncRNAs) represent a new group of host factors involved in viral infection. Current study identified an intergenic lncRNA, LINC08148, as proviral factor Zika virus (ZIKV) and Dengue 2 (DENV2). Knockout (KO) or silencing LINC08148 decreases the replication ZIKV DENV2. mainly acts at endocytosis step but later stage RNA-seq analysis reveals that knockout downregulates transcription levels five endocytosis-related genes including
Depressive symptoms are prevalent and cause poor health outcomes in patients with heart failure. Studies show that the physical of failure associated depressive symptoms. However, little is known about underlying mechanisms this relationship.The purpose our study was to examine associations between symptoms, illness perceptions, coping strategies test multiple mediation effects perceptions on relationship failure.Physical were assessed using self-reported questionnaires among 302 (64.2±11.9...
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus which has become a global epidemic threat due to its rapid spread and association with serious consequences of infection, including neonatal microcephaly. Inositol-requiring enzyme 1α (IRE1α) endoplasmic reticulum (ER)-related transmembrane protein that mediates unfolded response (UPR) pathway been indicated play important role in replication. However, the mechanism how IRE1α affects ZIKV replication remains unknown. In this study,...
Expression of host noncoding RNAs and coding mRNAs is significantly altered by viral infection. In the current study, we screened transcriptional profile human lung epithelial A549 cells infected with Zika virus (ZIKV) microarray assay. Seventy-nine long (lncRNAs) 140 were differentially expressed (DE). The bioinformatics analysis revealed that adjacent to DE lncRNAs closely related responses We selected 7 from top 50 hits for validation. quantitative real-time PCR data confirmed expression...
This study aimed to investigate the levels of nurses' organizational citizenship behaviour and associations between job burnout ethical climate with behaviour.Organizational improves adverse outcomes led by nursing shortage. However, three dimensions are inconsistent, little is known about whether related in nurses.In this cross-sectional study, 1157 nurses were selected using convenience sampling from April October 2019. Self-report surveys assessed behaviour, emotional exhaustion,...
Anxiety and depressive symptoms are common among patients with heart failure (HF). Physical limitations, lifestyle changes, uncertainties related to HF can result in the development or exacerbating of anxiety symptoms. However, central bridge network remain unclear. Network analysis is a statistical method that discover visualize complex relationships between multiple variables. This study aimed establish identify this HF. employed cross-sectional design convenience sampling recruit followed...
MOV10 protein has ATP-dependent 5'-3' RNA helicase activity and belongs to the UPF1p superfamily. It can inhibit human immunodeficiency virus type 1 (HIV-1) replication at multiple stages interact with apolipoprotein-B-mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G or A3G), a member of cytidine deaminase family that exerts potent inhibitory effects against HIV-1 infection. However, HIV-1-encoded virion infectivity factor (Vif) specifically mediates degradation A3G via...
Zika virus (ZIKV) is an emerging arthropod-borne and belongs to the Flaviviridae family. The infection of ZIKV has become global health crisis because its rapid spread association with severe neurological disorders, including congenital microcephaly Guillain-Barre Syndrome. To identify host factors contributing pathogenesis, transcriptomic landscape in ZIKV-infected cells was examined mRNA microarray analysis we observed that expression hydroxycarboxylic acid receptor 2 (HCAR2) could be...
Human immunodeficiency virus type 1 (HIV-1) can integrate viral DNA into host cell chromosomes to establish a long-term stable latent reservoir, which is major obstacle cure HIV-1 infection. The characteristics of the reservoir have not been fully understood. Here, we identified 126 upregulated plasma membrane proteins in latently infected cells by label-free liquid chromatography-tandem mass spectrometry analysis. higher levels CD98 expression multiple lines and primary CD4+ T compared...