A5102899343- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Epigenetics and DNA Methylation
- Non-Invasive Vital Sign Monitoring
- Dermatological and COVID-19 studies
- RNA modifications and cancer
- Extracellular vesicles in disease
- Ovarian cancer diagnosis and treatment
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Chemotherapy-induced organ toxicity mitigation
- Healthcare Technology and Patient Monitoring
- Wireless Sensor Networks and IoT
- Porphyrin and Phthalocyanine Chemistry
- Bioactive Compounds and Antitumor Agents
- Photodynamic Therapy Research Studies
- Photosynthetic Processes and Mechanisms
- Pancreatitis Pathology and Treatment
- Adenosine and Purinergic Signaling
- Geological Studies and Exploration
- Phagocytosis and Immune Regulation
- Fungal Plant Pathogen Control
- Cancer, Hypoxia, and Metabolism
Fudan University
2023-2024
Shanghai Public Health Clinical Center
2020-2024
Huashan Hospital
2020-2024
Shanxi University
2019-2024
Anyang Tumor Hospital
2023-2024
Henan University of Science and Technology
2023-2024
Hebei Agricultural University
2011-2023
Xinyang Normal University
2023
Shenzhen Institutes of Advanced Technology
2021
Mindray (China)
2021
Using a highly specific “lock and key” fluorescent Cys probe, we confirmed that targeting metabolism to deplete intracellular is more potent strategy sensitize cancer cells chemotherapies.
Abstract Discrimination of cancer cells/tissues from normal ones is critical importance for early diagnosis and treatment cancers. Herein, we present a new strategy high‐contrast fluorescence based on β‐Lapachone (β‐Lap, an anticancer agent) triggered ROS (reactive oxygen species) amplification specific in cells/tissues. With the strategy, wide range cells/tissues, including surgical tissue specimens harvested patients, were distinguished by using combination β‐Lap Si‐rhodamine‐based NIR...
A series of novel pyrazole-4-carboxamides bearing an ether group were designed and synthesized on the basis structure commercial succinate dehydrogenase inhibitor (SDHI) fungicide flubeneteram via scaffold hopping evaluated for their antifungal activities against five fungi. The bioassay results showed that most target compounds exhibited excellent in vitro activity Rhizoctonia solani some exerted remarkable Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium graminearum, Alternaria...
Boron–dipyrromethenes (Bodipys), since first reported in 1968, have emerged as a fascinating class of dyes the past few decades due to their excellent photophysical properties including bright fluorescence, narrow emission bandwidth, resistance photobleaching, and environment insensitivity. However, typical Bodipys are highly lipophilic, which often results nonfluorescent aggregates aqueous solution also severely limits bioavailability cells tissues. In this work, based on simple one-atom B...
Abstract Dysfunction of Tumour Suppressor Genes (TSGs) is a common feature in carcinogenesis. Epigenetic abnormalities including DNA hypermethylation or aberrant histone modifications promoter regions have been described for interpreting TSG inactivation. However, many instances, how TSGs are silenced tumours largely unknown. Given that miRNA with low expression another recognized signature, we hypothesize may reduce the activity related enhancers and further lead to inactivation during...
Abstract Currently, there is no effective drugs for treating clinically COVID-19 except dexamethasone. We previously revealed that human identical sequences of SARS-CoV-2 promote the progression by upregulating hyaluronic acid (HA). As inhibitor HA synthesis, hymecromone an approved prescription drug used biliary spasm. Here, we aimed to investigate relation between and COVID-19, evaluate therapeutic effects on COVID-19. Firstly, was closely relevant clinical parameters, including...
Leaf senescence reduces the photosynthetic capacity of leaves, thus significantly affecting growth, development, and yield formation cotton. Melatonin (MT) is a multipotent substance proven to delay leaf senescence. However, its potential mechanism in delaying induced by abiotic stress remains unclear. This study aimed explore effect MT on drought-induced cotton seedlings clarify morphological physiological mechanisms. Drought upregulated marker genes, destroyed photosystem, led excessive...
Fluorogenic probes have shown great potential in imaging biological species as well diagnosing diseases, especially cancers. However, the fluorogenic mechanisms are largely limited to a few photophysical processes date, typically including photoinduced electron transfer (PeT), fluorescence resonant energy (FRET), and intramolecular charge (ICT). Herein, by calculations experiments, we set forth that inhibition of excited-state π-conjugation meso-ester Si-rhodamine SiR-COOM or...
Abstract microRNAs (miRNAs) are short non-coding RNAs that have been increasingly recognized for their significant roles in the progression of cancer. Distinct miRNAs exhibit diverse functions attributed to variations sequences. As a result possessing highly homologous seed sequences, these target overlapping or similar gene sets, thus performing analogous roles. However, different from this sight, our study discovered miR-135a-5p and miR-135b-5p, despite differing by only one nucleotide,...
Abstract Discrimination of cancer cells/tissues from normal ones is critical importance for early diagnosis and treatment cancers. Herein, we present a new strategy high‐contrast fluorescence based on β‐Lapachone (β‐Lap, an anticancer agent) triggered ROS (reactive oxygen species) amplification specific in cells/tissues. With the strategy, wide range cells/tissues, including surgical tissue specimens harvested patients, were distinguished by using combination β‐Lap Si‐rhodamine‐based NIR...
Abstract As part of supportive therapy, prophylaxis with tiopronin for injection (TI) against common hepatotoxicity complications has often been used. However, methods to prevent have not established. Therefore, our study was aimed find out the relationship between periods TI and post-treatment hepatotoxicity, evaluated value prolonging duration administration in preventing hepatotoxicity. Hepatotoxicity detected through liver transaminases, bilirubin, alkaline phosphatase, clinical features...
SUMMARY The COVID-19 pandemic is a widespread and deadly public health crisis. pathogen SARS-CoV-2 replicates in the lower respiratory tract causes fatal pneumonia. Although tremendous efforts have been put into investigating pathogeny of SARS-CoV-2, underlying mechanism how interacts with its host largely unexplored. Here, by comparing genomic sequences human, we identified five fully conserved elements genome, which were termed as “human identical (HIS)”. HIS are also recognized both...
Abstract High metastatic propensity of osteosarcoma leads to its therapeutic failure and poor prognosis. Although nuclear activation miRNAs (NamiRNAs) are reported activate gene transcription via targeting enhancer further promote tumor metastasis, it remains uncertain whether NamiRNAs regulate metastasis their exact mechanism. Here, we found that extracellular vesicles the malignant cells (143B) remarkably increased migratory abilities MNNG representing benign by two folds, which attributed...
摘要: 为了明确渤海湾盆地渤中19-6大气田的地化特征和成因,选取研究区潜山凝析气藏7个凝析油样品进行全油色谱分析,剖析其轻烃组成特征,探讨轻烃参数在该区的地质应用.结果表明:渤中19-6凝析油的Mango轻烃参数K1和K2值相对稳定,表明研究区原油成因类型基本一致.C6~C8组成中正构烷烃具显著优势,甲基环己烷指数平均为39%;庚烷值与异庚烷值,正庚烷/甲基环己烷(F)比值较高,反映它们较高成熟度;轻烃参数计算原油生成温度为125.8~128.1 ℃,其相对偏低,可能与取样过程中凝析油的相态变化有关;2-甲基戊烷/3-甲基戊烷,2-甲基己烷/3-甲基己烷比值高,K2值低;凝析油正构烷烃摩尔浓度呈三段式分布,甲苯/正庚烷和原油蜡含量随深度而增加.结合饱和烃参数以及金刚烷参数揭示渤中19-6潜山油气为湖相腐泥Ⅱ1型母质在高成熟阶段(Ro=1.05%~1.30%)的产物,气藏形成后发生一定程度分馏造成油气组分调整. 关键词: 轻烃 / 原油 有机质来源 成熟度 次生作用 渤中凹陷 油气
OBJECTIVE The patient monitors were used to explore the alarm fatigue in a cardiac care unit and investigate awareness reaction of nurse alarms. METHODS A semi-structured survey was taken acquire nurses' feeling knowledge about monitoring alarm. Three full-time researchers scheduled track alarms with annotations, analyze data 12 using central system. RESULTS total 72 310 unique occurred 67-day study period. About 75.7% them physiological less than 10% medium-low false positives. average rate...
Abstract Solid-phase extraction (SPE) clean-up combined with solidified floating organic drop microextraction (SFODME) has been developed as a new approach for the and determination of trace manganese(II) in environmental water vegetable samples. After purification samples by graphene-packed SPE cartridge, SFODME technique was performed on obtained solution. The main parameters affecting performance SFODME, such type solvent well volume, time, temperature, pH, amount chelating agent, salt...
Abstract Background Internal hospital infection is one of the major public health concerns worldwide. To investigate etiological characteristics and risk factors infections after colorectal cancer(CRC) surgery formulation targeted control strategies. Methods This a retrospective analysis 1500 patients from cancer General Surgery between March 2018 2022，Anyang Tumor Hospital. Based on pathogen distribution results drug sensitivity testing, pattern pathogens resistance in hospitalized with...
Abstract purpose： As part of supportive therapy, prophylaxis with tiopronin for injection (TI) against common hepatotoxicity complications has often been used. However, methods to prevent have not established. Therefore, we analyzed the relationship between periods TI and its efficacy in preventing hepatotoxicity,evaluate value prolonging duration administration gynecological cancer patients. Methods This is a retrospective study. During 2022.1–2023.3, 452 patients were included this...