A5100657294- Cancer Cells and Metastasis
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Hormonal Regulation and Hypertension
- Cancer-related Molecular Pathways
- Prostate Cancer Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Acute Kidney Injury Research
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- Liver physiology and pathology
- Bladder and Urothelial Cancer Treatments
- Adrenal and Paraganglionic Tumors
- FOXO transcription factor regulation
- Thyroid and Parathyroid Surgery
- Uterine Myomas and Treatments
- Aldose Reductase and Taurine
- Ferroptosis and cancer prognosis
Capital Medical University
2014-2024
Beijing Anzhen Hospital
2013-2024
Foshan Second People's Hospital
2020
Southern Medical University
2020
The University of Texas MD Anderson Cancer Center
2016-2019
XinHua Hospital
2008-2017
Shanghai Jiao Tong University
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2011
Beijing Union University
2011
Xi'an Jiaotong University
2006-2007
Cancers with loss-of-function mutations in BRCA1 or BRCA2 are deficient the DNA damage repair pathway called homologous recombination (HR), rendering these cancers exquisitely vulnerable to poly(ADP-ribose) polymerase (PARP) inhibitors. This functional state and therapeutic sensitivity is referred as "BRCAness" most commonly associated some breast cancer types. Pharmaceutical induction of BRCAness could expand use PARP inhibitors other tumor For example, BRCA present only ~20% prostate...
Objectives: Epithelial‐mesenchymal transition (EMT) is an important process in tumor development, and several studies suggest that the Wnt/β‐catenin signal pathway may play role EMT. However, there no direct evidence showing actually determines EMT induced by exogenous signal. Our previous research has successfully proved overexpression of hypoxia‐inducible factor‐1α (HIF‐1α) could induce LNCaP cells, but not PC‐3. The present study aims to determine whether HIF‐1α for inducing prostate...
The cancer stem cell hypothesis suggests that neoplastic clones are maintained exclusively by a small subpopulation of cells, which have indefinite proliferation and differentiation potentials give rise to phenotypically diverse cells. Cancer cells been isolated their ability efflux Hoechst 33342 dye referred as the 'side population' (SP). assay was used isolate characterize SP from murine D121 lung carcinoma Here, we demonstrated D121-SP contain characteristics, is, upregulation...
In this study, we addressed the underlying mechanisms for association between enzalutamide (ENZ) treatment and neuroendocrine prostate cancer (NEPC), critical involvement of MYCN, loss RB1 function in differentiation (NED) prostatic epithelial cells, development NEPC. We further sought to determine whether PARP inhibition could suppress NEPC, identify molecular determinants therapeutic activity.We used a novel patient-derived xenograft (PDX) model, adenocarcinoma NEPC cell lines, an organoid...
Increasing evidence has shown that cancer stem cells or tumor initiating are the 'root cause' of malignant cancers. However, exact origin still remains obscure in thyroid research. EMT been implicated initiation and conversion early-stage tumors into invasive malignancies is associated with stemness cells. Based on these facts, a new hypothesis was suggested induces cell generation progression human vitro. In present study, FTC133 identified as EMT-negative were used for induction by HIF‑1α...
The interaction between the gut microbiome and cancer chemotherapy has been extensively studied. However, exact role of vaginal in remains unknown. To address this issue, we...
Hepatocyte growth factor (HGF) has been implicated in epithelial-mesenchymal transition (EMT) numerous types of cancer. However, to the best our knowledge, there no previous evidence that HGF a role prostate The present study aimed investigate effect on EMT and invasive potential, as well underlying molecular mechanisms, human cancer cell line. Therefore, PC-3 cells were treated with various concentrations for varying durations. EMT-associated proteins, including E-cadherin vimentin,...
Previous studies have shown that increased levels of chemokine receptor CXCR7 are associated with the invasiveness prostate cancer cells. We now show expression is upregulated in VCaP and C4-2B cells after enzalutamide (ENZ) treatment. ENZ treatment induced apoptosis (sub-G1) cells, this effect was further combination CCX771, a specific inhibitor. The p-EGFR (Y1068), p-AKT (T308) VEGFR2 were reduced CCX771 compared to single agent In addition, significantly greater reductions migration those...
Although cancer stem cells (CSCs) play a crucial role in seeding the initiation of tumor progression, they do not always possess same potent ability as metastasis. Thus, precisely how migrating CSCs occur, still remains unclear. In present study, we first comparatively analyzed series prostate CSCs, which exhibited dynamically increasing and disseminating nude mice. We observed that transcriptional activity HIF-1α β-catenin became gradually elevated these their epithelial-mesenchymal...
Hypoxia-inducible factor‑1α (HIF‑1α) is known to play crucial roles in tumor radioresistance; however, the molecular mechanisms responsible for promotion of radioresistance by HIF‑1α remain unclear. β‑catenin be involved metastatic potential prostate cancer (PCa). In this study, investigate role and PCa, two PCa cell lines, LNCaP C4‑2B, were grouped as follows: Negative control (no treatment), overexpression group (transfected with plasmid) silenced plasmids β‑catenin-shRNA). Cell...
c‑Met is a transmembrane tyrosine kinase receptor that may be activated by hepatocyte growth factor, an inducer of epithelial‑mesenchymal transition (EMT), to regulate the associated downstream gene expression. This process critical cell migration in normal and pathological conditions. In present study, function EMT was investigated prostate cancer. Initially, stable expression line constructed using EMT‑ c‑Met‑negative LNCaP cancer cells. Following identification transfected cells, changes...
Among a number of clinical factors, bacterial infection is one the most common causes acute lung injury (ALI), serious complication that carries high risk mortality (~40%). During process ALI, intense local and systemic inflammation elicited, which exacerbates injury. Neutrophil infiltration into airspace observed in early stage required for full development ALI through an array mechanisms, including release granule contents production pro‑inflammatory cytokines, due to overactivation...
It is critical to understand the molecular mechanisms underlying migration and invasiveness of prostate cancer (PC) for improving outcome therapy. A relationship pituitary tumor-transforming gene 1 (Pttg1) matrix metalloproteinase 13 (MMP13) in PC as well their roles metastases has not been studied. Here, we reported significantly higher levels Pttg1 MMP13 resected specimens, compared adjacent normal tissue from same patient. Interestingly, strongly correlated with each other. In vitro,...
Although carbon nanospheres (CNPs) are promising nanomaterials in cancer treatment, how they affect prostate (PCa) remains unclear.In this study, scanning electron microscopy (SEM), X-ray diffraction (XRD), and Raman spectroscopy were used to confirm the successful synthesis of CNPs. CCK-8, flow cytometry, Transwell, wound healing, Western blot immunohistochemistry (IHC) assays performed evaluate antitumor effect CNPs toward two kinds cell lines PC3 DU145.Our results showed that inhibited...
All-trans-retinoic acid (ATRA) can enhance iodine uptake capability of thyroid tumors, but the mechanisms remain poorly understood. The aim present study was to investigate effects ATRA on isotope susceptibility, proliferation and invasion anaplastic carcinoma (ATC) potential mechanisms. SW1736 cells were treated with 1 µmol/l or 1% ethanol for 5 days. A cell line stably expressing β-catenin-shRNA established. An assay performed using 125I. Proliferation invasiveness tested MTT Transwell...