A5100786642- Diabetes Treatment and Management
- Potassium and Related Disorders
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Diabetes Management and Research
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Dementia and Cognitive Impairment Research
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Cardiac Health and Mental Health
- Peptidase Inhibition and Analysis
- Reproductive System and Pregnancy
- Cardiac Imaging and Diagnostics
- Artificial Intelligence in Healthcare
- Down syndrome and intellectual disability research
- Bariatric Surgery and Outcomes
- Schizophrenia research and treatment
- Mechanical and Optical Resonators
- Death Anxiety and Social Exclusion
- Cardiac Arrhythmias and Treatments
- Metabolism, Diabetes, and Cancer
- Photoreceptor and optogenetics research
Peking University
2025
Ningxia Medical University
2025
Northwest A&F University
2024
First Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
China University of Mining and Technology
2024
Shihezi University
2023
Fudan University
2017-2023
State Key Laboratory of Medical Neurobiology
2022-2023
Huashan Hospital
2017-2023
Cardiac troponin is an independent predictor of cardiovascular mortality in individuals without symptoms or signs disease. The mechanisms for this association are uncertain, and a role testing the prevention coronary heart disease has yet to be established. This study sought determine whether concentration could predict events, modified by statins, reflect response therapy primary population. WOSCOPS (West Scotland Coronary Prevention Study) randomized men with raised low-density lipoprotein...
Objective To investigate whether an intensive early rheumatoid arthritis (RA) treat-to-target (T2T) strategy could be improved through the use of musculoskeletal ultrasound (MSUS) assessment disease activity. Methods 111 newly diagnosed patients with RA or undifferentiated (symptom duration <1 year) were randomised to strategies that aimed attain either DAS28-erythrocyte sedimentation rate (ESR)<3.2 (control) a total power Doppler joint count≤1 during combined DAS28-ESR/MSUS...
To examine the manifestation of cardiovascular or renal disease (CVRD) in patients with type 2 diabetes (T2D) initially free from CVRD as well mortality risks associated these diseases.Patients were identified healthcare records England, Germany, Japan, Netherlands, Norway and Sweden at a fixed date. was defined by first diagnosis cardiorenal disease, stroke, myocardial infarction (MI) peripheral artery (PAD) event. The risk single history heart failure (HF), chronic kidney (CKD), MI, stroke...
There are few contemporary data on outcomes, costs, and treatment following a hospitalization for heart failure (hHF) in epidemiologically representative cohorts.This study sought to describe rehospitalizations, use of guideline-directed medical therapy (GDMT) (renin-angiotensin system inhibitors, sacubitril/valsartan, beta-blockers, mineralocorticoid receptor antagonists, sodium-glucose cotransporter-2 inhibitors), mortality after hHF.EVOLUTION HF (Utilization Dapagliflozin Other Guideline...
To assess cardiovascular magnetic resonance (CMR) measured myocardial perfusion reserve (MPR) and exercise testing in asymptomatic patients with moderate-severe AS. Multi-centre, prospective, observational study, blinded analysis of CMR data. Patients underwent adenosine stress CMR, symptom-limited (ETT) echocardiography were followed up for 12–30 months. The primary outcome was a composite of: typical AS symptoms necessitating referral AVR, death major adverse events. 174 recruited: mean...
To examine the seizure trajectories of adults with epilepsy developing drug-resistant (DRE) and to identify predictors trajectory outcome.Adult patients failing two antiepileptic drugs (AEDs) due inefficacy starting their third AED at a tertiary center were followed for outcome during medical management. Seizure categorized into one four patterns: (1) course constant seizures; (2) fluctuating course; (3) delayed attainment freedom (seizure >12 months after start study, but patient stayed in...
Abstract Aims We compared the new use of sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) versus dipeptidyl peptidase‐4 (DPP4i) and risk cardiorenal disease, heart failure (HF) or chronic kidney disease (CKD), in patients with type 2 diabetes without a history prevalent cardiovascular renal defined as (CVRD) free, managed routine clinical practice. Materials methods In this observational cohort study, were identified from electronic health records England, Germany, Japan, Norway, South...
Abstract Background Cardiovascular and renal diseases (CVRD) are major causes of mortality in individuals with type 2 diabetes (T2D). Studies lifetime risk have neither considered all CVRD together nor the relative contribution factors to combined disease burden. Methods In a population-based cohort study using national electronic health records, we studied 473,399 T2D England 2007–2018. Lifetime individual adverse cardiovascular events, MARCE (including CV death CVRD: heart failure; chronic...
<title>Abstract</title> Chirality and chaos, both rooted in symmetry breaking, have been long intriguing fundamental applied physics. Despite their shared foundation, these two concepts largely evolved independently, leaving unexplored potential at intersection. Here, we report chaos-induced optical chirality a quantum-dot microlaser, establishing the first direct link between phenomena. We reveal that chaotic light dynamics breaks time-reversal symmetry, creating locally imbalanced...
Obesity is a major public health concern requiring innovative interventions that support people to lose weight and keep it off long term. However, loss maintenance remains challenge under-researched, particularly in men. The Football Fans Training (FFIT) programme engages men management through their interest football, encourages them incorporate small, incremental physical activity dietary changes into daily life long-term maintenance. In 2011/12, randomised controlled trial (RCT) of FFIT...
Abstract Endometriosis is a refractory estrogen-dependent gynecological disease in which ovarian endometriosis(OE) the most common, and main cell components are endometrial epithelial cells stromal cells. However, constructing ectopic models basic studies still challenging. In this study, we explored feasibility influencing factors of validating eutopic organoid OE as in-vitro models. Eutopic tissues patients were selected to establish organoids. Morphologically, organoids showed...
Abstract Aims Ischaemic heart disease persists as the leading cause of death in both men and women most countries sex disparities, defined differences health outcomes their determinants, may be relevant. We examined disparities presenting characteristics, treatment all-cause mortality patients hospitalized with myocardial infarction (MI) or angina. Methods results conducted a cohort study all admitted MI angina (01 October 2013 to 30 June 2016) from secondary care acute coronary syndrome...
To assess if sodium-glucose co-transporter-2 inhibitors (SGLT2is) reduce the risk of all-cause mortality, cardiovascular death and hospitalization for heart failure (HF) or chronic kidney disease (CKD) to a greater extent than dipeptidyl peptidase-4 (DPP4is) in people with type 2 diabetes (T2D) without established and/or renal (CVRD).This retrospective cohort study propensity-matched 24 438 patients receiving an SGLT2i 1:1 patient DDP4i, stratified based on presence CVRD. The primary...
Abstract Excessive ultraviolet B ray (UVB) exposure to sunlight results in skin photoageing. Our previous research showed that a Q‐switched 1064 nm Nd: YAG laser can alleviate barrier damage through miR‐24‐3p. However, the role of autophagy treatment photoageing is still unclear. This study aims investigate whether involved mechanism ageing. In vitro, primary human dermal fibroblast ( HDF) cells were irradiated with different doses UVB establish cell model vivo, SKH‐1 hairless mice mouse and...
Abstract Background Resting heart rate (RHR) has been linked with an increased risk of dementia. However, evidence characterizing the associations RHR different dementia subtypes and their underlying mechanisms remains scarce. This study aims to investigate relationships types, cognitive function, brain structural abnormalities. Methods Three hundred thirty-nine thousand nine one participants no prior diagnosis from UK biobank were analyzed. Cox regression restricted cubic spline models...
Evidence supporting cardiovascular diseases could increase the risk of dementia remains fragmented. A comprehensive study to illuminate distinctive associations across different types is still lacking. This sought to: (1) determine clinical validity Framingham General Cardiovascular Risk Score (FGCRS) for assessment and (2) examine between dementia.
To confirm the reno-protective effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors compared with dipeptidyl peptidase-4 (DPP-4) on onset and progression chronic kidney disease (CKD) in routine clinical practice.We conducted a retrospective cohort study using Clinical Practice Research Datalink Aurum database linked to Hospital Episode Statistics. The primary outcome was risk composite CKD endpoint based recent consensus guidelines for disease: >40% decline estimated glomerular...