A5067796695- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Vestibular and auditory disorders
- Axon Guidance and Neuronal Signaling
- Muscle Physiology and Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Nerve injury and regeneration
- Glaucoma and retinal disorders
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Wnt/β-catenin signaling in development and cancer
- HER2/EGFR in Cancer Research
- Neuroscience of respiration and sleep
- Neuroscience, Education and Cognitive Function
- Regulation of Appetite and Obesity
- Genetics and Neurodevelopmental Disorders
- Cancer-related cognitive impairment studies
- Ion Channels and Receptors
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular transport and secretion
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Neurobiology and Insect Physiology Research
- Myasthenia Gravis and Thymoma
Huazhong University of Science and Technology
2016-2025
Augusta University
2012-2017
Augusta University Health
2011-2012
Tsinghua University
2006
Myasthenia gravis (MG) is the most common disorder affecting neuromuscular junction (NMJ). MG frequently caused by autoantibodies against acetylcholine receptor (AChR) and a kinase critical for NMJ formation, MuSK; however, proportion of patients are double-negative anti-AChR anti-MuSK antibodies. Recent studies in these subjects have identified low-density lipoprotein receptor-related protein 4 (LRP4), an agrin also formation. LRP4 not previously been implicated pathogenesis. Here we...
The neuromuscular junction (NMJ) is a synapse between motor neurons and skeletal muscle fibers, critical for control of contraction. Its formation requires neuronal agrin that acts by binding to LRP4 stimulate MuSK. Mutations have been identified in , MuSK patients with congenital myasthenic syndrome, myasthenia gravis develop antibodies against agrin, LRP4, However, it remains unclear whether the signaling pathway NMJ maintenance because null mutation any three genes perinatal lethal. In...
The entorhinal cortex (EC) is one of the most vulnerable brain regions that attacked during early stage Alzheimer's disease (AD). Here, we report synaptic terminals pyramidal neurons in EC layer II (ECIIPN) directly innervate CA1 parvalbumin (PV) (CA1PV) and are selectively degenerated AD mice, which exhibit amyloid-β plaques similar to those observed patients. A loss ECIIPN–CA1PV synapses disables excitatory inhibitory balance circuit impairs spatial learning memory. Optogenetic activation...
The vestibular system may have a critical role in the integration of sensory information and maintenance cognitive function. A dysfunction has significant impact on quality life. Recent research provided evidence connection between functions, such as spatial memory, navigation attention. Although exact mechanisms linking to cognition remain elusive, researchers identified various pathways. Vestibular lead degeneration cortical network regions adversely affect synaptic plasticity neurogenesis...
Yes-associated protein (Yap) is a major effector of the Hippo pathway that regulates cell proliferation and differentiation during development restricts tissue growth in adult animals. However, its role synapse formation remains poorly understood. In this study, we characterized Yap's neuromuscular junction (NMJ). HSA-Yap −/− mice where Yap was mutated specifically muscle cells, AChR clusters were smaller distributed broader region middle fibers, suggesting necessary for size location...
Hippocampal neurogenesis persists throughout adult life and plays an important role in learning memory. Although the influence of physical exercise on has been intensively studied, there is controversy regard to how impact may vary with its regime. Less known about distinct paradigms differentially affect behavior. Here we found that, chronic moderate treadmill running led increase cell proliferation, survival, neuronal differentiation, migration. In contrast, intense only promoted...
Neuromuscular junction formation requires proper interaction between motoneurons and muscle cells. β-Catenin (Ctnnb1) in is critical for motoneuron differentiation; however, little known about the relevant retrograde signal. In this paper, we dissected which functions of Ctnnb1 are by an vivo transgenic approach. We show that mutant without transactivation domain was unable to rescue presynaptic deficits mutation, indicating involvement transcription regulation. On other hand, cell-adhesion...
Neuromuscular junction (NMJ) formation requires proper interaction between motoneurons and muscle cells. β-Catenin is required in cells for NMJ formation. To understand underlying mechanisms, we investigated the effect of β-catenin gain function (GOF) on development. In HSA-β-cat(flox(ex3)/+) mice, which express stable specifically muscles, motor nerve terminals became extensively defasciculated arborized. Ectopic muscles were observed diaphragm innervated by ectopic phrenic branches....
Noise-induced hearing loss (NIHL) is a prevalent form of adult impairment, characterized by oxidative damage to auditory sensory hair cells. Although certain dihydropyridines, the L-type calcium channel blockers, exhibit protective properties against such damage, ability third-generation dihydropryidines like lercanidipine mitigate NIHL remains unclear.We utilized glucose oxidase (GO)-treated OC1 cell lines and cochlear explants evaluate influence on To further investigate its effectiveness,...
Physical exercise can alleviate some of the schizophrenia symptoms in patients, mechanisms, however, are still unclear. To investigate whether GABAergic interneuron involved therapeutic effect treadmill running on schizophrenia, parvalbumin (PV)-positive interneurons dentate gyrus (DG) was specifically activated or abolished and effects were evaluated. In MK801-induced schizophrenia-like animal model, we found:(1) Treadmill rescued schizophrenia-related behavioral phenotypes, promoted adult...
Liver-expressed antimicrobial peptide 2 (LEAP2) is a newly discovered antagonist of the growth hormone secretagogue receptor (GHSR) and considered first endogenous that can antagonize metabolic actions ghrelin. The effects ghrelin administration on feeding behavior, body weight, energy metabolism involve activation orexigenic neurons in arcuate nucleus (ARC) hypothalamus. It unclear, however, if LEAP2 applied directly to ARC hypothalamus affects these processes. Here, we show overexpression...
Malfunction of the ventral subiculum (vSub), main subregion controlling output connections from hippocampus, is associated with major depressive disorder (MDD). Although vSub receives cholinergic innervation medial septum and diagonal band Broca (MSDB), whether how MSDB-to-vSub circuit involved in MDD elusive. Here, we found that chronic unpredictable mild stress (CUMS) induced depression-like behaviors hyperactivation neurons, measured by c-fos staining whole-cell patch-clamp recording. By...
Vestibular compensation is a natural behavioral recovery process following unilateral vestibular injury. Understanding the mechanism can considerably enhance disorder therapy and advance adult central nervous system functional plasticity study after The cerebellum, particularly flocculonodular lobe, tightly modulates nucleus, center for compensation; however, it still unclear if flocculus on both sides involved in compensation. Here we report that unipolar brush cells (UBCs) are modulated by...
Abstract Long non‐coding RNAs (lncRNAs) have emerged as crucial regulators in the central nervous system, yet their role vestibular compensation remains elusive. To address this knowledge gap, we employed unilateral labyrinthectomy (UL) rats to establish animal models of peripheral dysfunction. Utilizing ribonucleic acid sequencing (RNA‐seq), comprehensively analysed expression profiles genes dysregulated medial nucleus (MVN) these at distinct time points: 4 h, days, and 14 days post‐UL....
The vestibular system is essential for balance and spatial orientation, its dysfunction can lead to cognitive deficits. This study investigates the effects of unilateral (UVL) on function underlying neurobiological changes in mice. We established a labyrinthectomy (UL) model mice assessed at 28 days post-surgery using comprehensive battery behavioral tests. found significant impairments reference memory, working synaptic plasticity UL mice, which persisted despite compensation postural motor...
Highlights•Suppression of SOCE in the brain ameliorates dietary obesity•Deficiency Stim1 AgRP neurons protects against DIO•SOCE inhibition impedes general translation via Oas3-RNase L signaling•The signaling mediates anti-obesity effect ASKOSummaryStore-operated calcium entry (SOCE) is pivotal maintaining intracellular Ca2+ level and cell function; however, its role obesity development remains largely unknown. Here, we show that stromal interaction molecule 1 (Stim1), an endoplasmic...
Dopamine D1 receptor (D1R) hypofunction is associated with negative and cognitive symptoms in schizophrenia; therefore, the mechanism of D1R function modulation needs further investigation. Gm527 rodent homologous schizophrenia-related gene C14orf28, encoding a predicated D1R-interacting protein. However, role Gm527-D1R interaction schizophrenia to be clarified.Gm527-floxed mice were generated crossed D1-Cre (D1:Gm527-/-) knockout D1R-positive neurons. Then behavioral tests performed explore...
Abstract Aims To investigate the role of mGluR1α in cerebellar unipolar brush cells (UBC) mediating vestibular compensation (VC), using agonist and antagonist to modulate ON UBC neurons, explore mGluR1/IP3/extracellular signal‐regulated kinase (ERK) signaling pathway. Methods First, AAV virus that knockdown (mGluR1α) were injected into by stereotactic, verified immunofluorescence western blot. The effect on VC was evaluated after unilateral labyrinthectomy (UL). Second, saline,...