A5049399014- Neurobiology and Insect Physiology Research
- Cellular transport and secretion
- Myasthenia Gravis and Thymoma
- Cellular Mechanics and Interactions
- Muscle Physiology and Disorders
- Invertebrate Immune Response Mechanisms
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Nuclear Structure and Function
- Autism Spectrum Disorder Research
- Neuroscience and Neuropharmacology Research
- Fuel Cells and Related Materials
- HER2/EGFR in Cancer Research
- Axon Guidance and Neuronal Signaling
- Physiological and biochemical adaptations
- Internet Traffic Analysis and Secure E-voting
- Thermoregulation and physiological responses
- Signaling Pathways in Disease
- Neural dynamics and brain function
- Hippo pathway signaling and YAP/TAZ
- Neurotransmitter Receptor Influence on Behavior
- Protein Kinase Regulation and GTPase Signaling
- RNA and protein synthesis mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Memory and Neural Mechanisms
Case Western Reserve University
2018-2023
Southeast University
2011-2018
University School
2018
Augusta University
2016-2017
Institute of Life Sciences
2017
Génétique et biologie du développement
2011
Institut thématique Génétique, génomique et bioinformatique
2011
Neuroligins belong to a highly conserved family of cell adhesion molecules that have been implicated in synapse formation and function. However, the precise vivo roles remain unclear. In present study, we analyzed function Drosophila neuroligin 2 ( dnl2 ) synaptic development We show is strongly expressed embryonic larval CNS at neuromuscular junction (NMJ). null mutants are viable but display numerous structural defects NMJ, including reduced axonal branching fewer boutons. also an increase...
Yes-associated protein (Yap) is a major effector of the Hippo pathway that regulates cell proliferation and differentiation during development restricts tissue growth in adult animals. However, its role synapse formation remains poorly understood. In this study, we characterized Yap's neuromuscular junction (NMJ). HSA-Yap −/− mice where Yap was mutated specifically muscle cells, AChR clusters were smaller distributed broader region middle fibers, suggesting necessary for size location...
During aging, acetylcholine receptor (AChR) clusters become fragmented and denervated at the neuromuscular junction (NMJ). Underpinning molecular mechanisms are not well understood. We showed that LRP4, a for agrin critical NMJ formation maintenance, was reduced protein level in aged mice, which associated with decreased MuSK tyrosine phosphorylation, suggesting compromised agrin-LRP4-MuSK signaling muscles. Transgenic expression of LRP4 muscles alleviated AChR fragmentation denervation...
Neuroligins are postsynaptic adhesion molecules that essential for specialization and synaptic function. But the underlying molecular mechanisms of neuroligin functions remain unclear. We found Drosophila Neuroligin 1 (DNlg1) regulates structure function through WAVE regulatory complex (WRC)-mediated actin reorganization. The disruption DNlg1, DNlg2, or their presynaptic partner neurexin (DNrx) led to a dramatic decrease in amount F-actin. Further study showed but not DNlg2 DNlg3, directly...
Significance NRG1–ErbB4 signaling is implicated in GABAergic circuit assembly during development and transmission at adulthood. However, it unclear whether phenotypes the adult stage ErbB4 mutant mice result from abnormal neural development. By using two strains of with temporal control deletion expression, we demonstrate that impaired behavior GABA release, whereas deficits due to null mutation were alleviated by restoring expression stage. Together, our results indicate adulthood critical...
Abstract Proprioception is sensed by muscle spindles for precise locomotion and body posture. Unlike the neuromuscular junction (NMJ) contraction which has been well studied, mechanisms of spindle formation are not understood. Here we show that sensory nerve terminals disrupted mutation Lrp4 , a gene required NMJ formation; inducible knockout in adult mice impairs synapses movement coordination, suggesting LRP4 maintenance. critical to expression Egr3 during development; mice, it interacts...
Neuromuscular junction is a synapse between motoneurons and skeletal muscles, where acetylcholine receptors (AChRs) are concentrated to control muscle contraction. Studies of this have contributed our understanding assembly pathological mechanisms neuromuscular disorders. Nevertheless, underlying NMJ formation was not well understood. To end, we took novel approach – studying mutant genes implicated in congenital myasthenic syndrome (CMS). We showed that knock-in mice carrying N88K,...
Abstract Dopamine (DA) neurons in the ventral tegmental area (VTA) are critical to coping with stress. However, molecular mechanisms regulating their activity and stress-induced depression were not well understood. We found that receptor tyrosine kinase ErbB4 VTA was activated stress-susceptible mice. Deleting or DA neurons, chemical genetic inhibition of suppressed development chronic social defeat stress (CSDS)-induced depression-like behaviors. activation required expression NRG1...
During aging, skeletal muscles become atrophic and lose contractile force. Aging can also impact the neuromuscular junction (NMJ), a synapse that transmits signals from motoneurons to muscle fibers control contraction. However, in contrast aging has been studied extensively, less is known about molecular mechanisms of NMJ although its structure function are impaired aged animals. To this end, we performed RNA sequencing (RNA-seq) analysis identify genes whose expression synapse-rich region...
This paper presents a novel key issuing scheme for distributed online social networks based on identity-based encryption (IBE). The involves two essential objects, Key Privacy Authority (KPA) and Chum (PC). KPA PC cannot impersonate network users to obtain users’ private keys. experiment results indicate that the is feasible efficient, it can sustain large-scale networks.