A5100337900- Wound Healing and Treatments
- Stroke Rehabilitation and Recovery
- Neuroblastoma Research and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Immune cells in cancer
- Advanced Neuroimaging Techniques and Applications
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Resilience and Mental Health
- Plasma Diagnostics and Applications
- Dermatologic Treatments and Research
- Neurological disorders and treatments
- Mycobacterium research and diagnosis
- Extracellular vesicles in disease
- Anesthesia and Pain Management
- Plasma Applications and Diagnostics
- Ubiquitin and proteasome pathways
- Voice and Speech Disorders
- Immune Cell Function and Interaction
- Pressure Ulcer Prevention and Management
- T-cell and B-cell Immunology
- interferon and immune responses
- Medical and Biological Sciences
- RNA modifications and cancer
Army Medical University
2019-2025
Southwest Hospital
2019-2025
First Hospital of Shijiazhuang
2025
Dalian Medical University
2024-2025
Chongqing Medical University
2024-2025
Second Affiliated Hospital of Chongqing Medical University
2024-2025
Huazhong University of Science and Technology
2024
Guangxi Medical University
2024
Wuhan Children's Hospital
2024
Zhejiang A & F University
2023
Plant growth and development are significantly hampered in saline environments, limiting agricultural productivity. Thus, it is crucial to unravel the mechanism underlying plant responses salt stress. β-1,4-Galactan (galactan), which forms side chains of pectic rhamnogalacturonan I, enhances sensitivity high-salt Galactan synthesized by GALACTAN SYNTHASE1 (GALS1). We previously showed that NaCl relieves direct suppression GALS1 transcription factors BPC1 BPC2 induce excess accumulation...
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of malignancy. Although some patients benefit from immune checkpoint therapy, current treatment methods rely mainly on chemotherapy. It imperative to develop predictors efficacy and identify individuals who will be sensitive particular regimens. This study analyzed peripheral interferons cell subsets in TNBC receiving pre-operative neoadjuvant therapy. The effects interferon-induced helicase 1 (IFIH1) the biological...
1α,25-Dihydroxyvitamin D3 (VD3), the active form of vitamin D, plays a crucial role in wound healing. In this study, we aimed to investigate effect VD3 on proliferation and differentiation epidermal stem cells (EpSCs) monitor its impact re-epithelialization. We established murine full-thickness skin defect model applied four doses (0, 5, 50, 250 ng/mouse/day) wounds topically for three days. Immunostaining flow cytometry confirmed EpSCs wounds. This 1, 10, 50 nM) possible mechanism were...
Background and objectives: Stroke commonly results in physical dysfunction seriously affects the quality of life. We aimed to estimate prevalence association resilience with life among patients at hospitalization whether was independent function, anxiety, depression, other population characteristics.Methods: A cross-sectional study a tertiary hospital included 215 individuals. The Chinese version Connor-Davidson Resilience Scale used evaluate resilience. Quality measure Other validated...
Silver-containing wound dressings have shown attractive advantages in the treatment of infection due to their excellent antibacterial activity. However, introduction silver ions or AgNPs directly into can cause deposition body as particles. Here, with aim designing low-silver dressings, a bimetallic-MOF material called AgCu@MOF was developed using 3, 5-pyridine dicarboxylic acid ligand and Ag+ Cu2+ metal ion sites. PCbM (PVA/chitosan/AgCu@MOF) hydrogel successfully constructed PVA/chitosan...
Restenosis is a serious problem in patients who have undergone percutaneous transluminal angioplasty. Endothelial injury resulting from surgery can lead to endothelial dysfunction and neointimal formation by inducing aberrant proliferation migration of vascular smooth muscle cells. Exosomes secreted mesenchymal stem cells been hot topic cardioprotective research. However, date, exosomes derived (MSC-Exo) rarely reported association with restenosis after artery injury. The aim this study was...
As a potential clinical therapeutic cell for injured tissue repair, mesenchymal stem cells (MSCs) have attracted increasing attention. Enhancing the pro-healing function of MSCs has gradually become an essential topic in improving efficacy MSCs. Recently, studies shown that neuronal protein 3.1 (P311) plays crucial role promoting skin wound healing, suggesting P311 gene modification may improve In this study, we demonstrated vivo expression could significantly enhance ability to lessen...
To explore (a) resilience among patients over the first 6 months following a ischaemic stroke; (b) factors associated with at hospitalization, 1, 3, and postdischarge; (c) baseline predictors of postdischarge.a cohort study.From February 2017-January 2018, 217 presenting two hospitals stroke were recruited. Their resilience, medical coping styles, general self-efficacy, functional independency, socio-demographic, clinical data assessed while they still in hospital (baseline) after...
In this qualitative, descriptive study, we explored the status of and factors related to nursing practice for stroke rehabilitation in China, considering perspectives multi-disciplinary healthcare professionals. Fifteen participants were interviewed depth, followed by field observations at three institutions. Data analyzed using ethnographic data analysis methods. Current patients with emerged as a cultural domain that included nine patterns: coordination nursing, basic following procedures,...
Abstract Background Efficient re-epithelialization is important for successful skin wound healing. The proportion of epidermal stem cells (EpSCs) and dendritic T (DETCs) determines the extent re-epithelialization, especially in large areas tissue loss. However, it remains unknown whether how DETCs regulate status EpSCs to impact re-epithelialization. Methods To investigate we utilized normal or full-thickness deficient wide type (WT) mice Tcrσ knockout (Tcrσ −/− ) with DETCs-derived exosomes...
Loss-of-function mutations in the polycomb repressive complex 2 (PRC2) occur frequently malignant peripheral nerve sheath tumor, an aggressive sarcoma that arises from NF1-deficient Schwann cells. To define oncogenic mechanisms underlying PRC2 loss, we use engineered cells dynamically reassemble a competent coupled with single-cell sequencing clinical samples. We discover two-pronged process: first, loss leads to remodeling of bivalent chromatin and enhancer landscape, causing upregulation...
Delayed wound healing remains a common but challenging problem in patients with acute or chronic following accidental scald burn injury. However, the systematic and detailed evaluation of injury, including second-degree deep (SDDS) third-degree (TDS), is still unclear. The present study aims to analyze wound-healing speed, formation granulation tissue, quality after cutaneous damage.In order assess SDDS TDS, models TDS were established using instrument C57BL/6 mice. Furthermore, an...
Abstract As an inflammatory factor, IL‐25 has been studied in variouscancers, but it is rarely reported cancer chemotherapy resistance. Major vault protein (MVP), as a gene associated with lung multidrug resistance, multiple resistances of cancer. However, the relationship between and MVP cells not studied. In this study, we found that both were elevated expressed cisplatin‐resistant adenocarcinoma cell line (A549/CDDP). Silencing resulted down‐regulation expression reduced cisplatin...
Abstract Perifosine, an Akt inhibitor, has been shown to be effective in controlling neuroblastoma tumor growth. However, studies indicate that addition the ability inhibit Akt, other mechanisms contribute perifosine’s anti-tumor activity. To gain insight into perifosine activity we have studied changes proteome and acetylome after treatment SK-N-AS cells using SILAC labeling, affinity enrichment, high-resolution LC-MS/MS analysis. Bioinformatic analysis indicates that, a total of 5,880...