A5000473787- Personality Traits and Psychology
- Nuclear reactor physics and engineering
- Mental Health Research Topics
- Nuclear Physics and Applications
- Cognitive Abilities and Testing
- Child and Adolescent Psychosocial and Emotional Development
- Probabilistic and Robust Engineering Design
- Functional Brain Connectivity Studies
- Graphite, nuclear technology, radiation studies
- Electron and X-Ray Spectroscopy Techniques
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Personality Disorders and Psychopathology
- Statistical Methods and Inference
- Psychometric Methodologies and Testing
- Nuclear Materials and Properties
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Markov Chains and Monte Carlo Methods
- Behavioral Health and Interventions
- Health disparities and outcomes
- Mathematical Approximation and Integration
- Nuclear and radioactivity studies
- Theoretical and Computational Physics
- Bullying, Victimization, and Aggression
University of Edinburgh
2016-2025
National Radio Astronomy Observatory
2022
Los Alamos National Laboratory
2007-2020
Alzheimer Scotland
2018-2020
Edinburgh Royal Infirmary
2018
King's College London
2018
Trinity College
2018
Beaumont Hospital
2018
University of Manchester
2010-2012
Computational Physics (United States)
2011
MCNP6 is simply and accurately described as the merger of MCNP5 MCNPX capabilities, but it much more than sum those two computer codes. result five years effort by code development teams. These groups people, residing in Los Alamos National Laboratory's (LANL) X Computational Physics Division, Monte Carlo Codes Group (XCP-3), Decision Applications Radiation Transport Team (D-5), respectively, have combined their efforts to produce next evolution MCNP. While maintenance bug fixes will...
Background Sex differences in personality are believed to be comparatively small. However, research this area has suffered from significant methodological limitations. We advance a set of guidelines for overcoming those limitations: (a) measure with higher resolution than that afforded by the Big Five; (b) estimate sex on latent factors; and (c) assess global multivariate effect sizes. then apply these large, representative adult sample, obtain what is presently best personality....
Cerebral small vessel disease (SVD) may cause cognitive dysfunction. We tested the association between combined presence of magnetic resonance imaging (MRI) features SVD and ability in older age. Cognitive testing brain MRI were performed 680 participants. lacunes, white matter hyperintensities, microbleeds, perivascular spaces summed a score 0–4 representing all combined. also applied latent variable modeling to test whether 4 form unitary construct. The showed significant associations with...
To elucidate the relationship between disease stage in amyotrophic lateral sclerosis (ALS), as measured with King's Clinical Staging System, and cognitive behavioral change, Edinburgh Cognitive Behavioural ALS Screen (ECAS).A large multicenter observational cohort of 161 cross-sectional patients 80 healthy matched controls were recruited across 3 research sites (Dublin, Edinburgh, London). Participants administered ECAS categorized into independent groups based on their clinical at time...
Importance Cerebral small vessel disease (cSVD) is a common cause of stroke (lacunar stroke), the most vascular cognitive impairment, and impairs mobility mood but has no specific treatment. Objective To test feasibility, drug tolerability, safety, effects 1-year isosorbide mononitrate (ISMN) cilostazol treatment on vascular, functional, outcomes in patients with lacunar stroke. Design, Setting, Participants The Lacunar Intervention Trial-2 (LACI-2) was an investigator-initiated, open-label,...
This study assessed change in self-reported Big Five personality traits. We conducted a coordinated integrative data analysis using from 16 longitudinal samples, comprising total sample of over 60 000 participants. models across multiple datasets and fit identical multi-level growth to assess compare the extent trait time. Quadratic was subset samples with four or more measurement occasions. Across studies, linear trajectory revealed declines conscientiousness, extraversion, openness....
Associations between brain cortical tissue volume and cognitive function in old age are frequently interpreted as suggesting that preservation of is the foundation successful aging. However, this association could also, part, reflect a lifelong ability tissue. We analyzed data on 588 subjects from Lothian Birth Cohort 1936 who had intelligence quotient (IQ) scores same test available at both 11 70 years well high-resolution magnetic resonance imaging obtained approximately 73 age. Cortical...
People with larger brains tend to score higher on tests of general intelligence (g). It is unclear, however, how much variance in other brain measurements would account for if included together volume a multivariable model. We examined large sample individuals their seventies (n = 672) who were administered comprehensive cognitive test battery. Using structural equation modelling, we related six common magnetic resonance imaging-derived variables that represent normal and abnormal...
The current article compares the use of exploratory structural equation modeling (ESEM) as an alternative to confirmatory factor analytic (CFA) models in personality research. We compare model fit, distinctiveness, and criterion associations factors derived from ESEM CFA models. In Sample 1 ( n = 336) participants completed NEO-FFI, Trait Emotional Intelligence Questionnaire–Short Form, Creative Domains Questionnaire. 2 425) Big Five Inventory depression anxiety scales General Health...
Cerebral white matter hyperintensities (WMH) reflect accumulating damage with aging and impair cognition. The role of childhood intelligence is rarely considered in associations between cognitive impairment WMH. We studied community-dwelling older people all born 1936, whom IQ had been assessed at age 11 years. medical histories, current ability quantified WMH on MR imaging. Among 634 participants, mean 72.7 (SD 0.7), was the strongest predictor late life ability. After accounting for IQ,...
Brain tissue deterioration is a significant contributor to lower cognitive ability in later life; however, few studies have appropriate data establish how much influence prior brain volume and performance on this association. We investigated the associations between structural imaging biomarkers, including an estimate of maximal volume, detailed measures at age 73 years large (N = 620), generally healthy, community-dwelling population. Cognitive were available from 11 years. found positive...
Allostatic load (AL) has been proposed as a general framework for understanding the cumulative effects of life stress on individuals. Despite growing interest in AL, limited research conducted aging samples. We consider association AL (operationalized by range inflammatory, cardiovascular, and metabolic measures) with brain volume measurements cognitive ability large cohort sample older adults (n = 658, mean age 72.5 years, standard deviation 0.7) using structural equation modeling. was...
Previous studies have hinted at sex differences in developmental trajectories ADHD symptoms; however, little is known about the nature or cause of these and their implications for clinical practice. We used growth mixture modelling a community-ascertained cohort n = 1,571 participants to study symptom across elementary secondary school years. Participants were measured ages 7, 8, 9, 10, 11, 12, 13, 15. found that females more likely show large increases early adolescence while males elevated...
Abstract. In pursuit of a more systematic and comprehensive framework for personality assessment, we introduce procedures assessing traits at the lowest level: nuances. We argue that constructing taxonomy from bottom up addresses some limitations extant top-down assessment frameworks (e.g., Big Five), including opportunity to resolve confusion about breadth scope different levels organization, evaluate unique reliable trait variance item level, clarify jingle/jangle issues in assessment....
Perivascular Spaces (PVS), also known as Virchow-Robin spaces, seen on structural brain MRI, are important fluid drainage conduits and associated with small vessel disease (SVD). Computational quantification of visible PVS may enable efficient analyses in large datasets increase sensitivity to detect associations disorders. We assessed the computationally-derived parameters vascular factors white matter hyperintensities (WMH), a marker SVD.Community dwelling individuals (n = 700) from...
Current literature suggests that neuroticism is positively associated with maladaptive life choices, likelihood of disease, and mortality. However, recent research has identified circumstances under which positive outcomes. The current project examined whether "healthy neuroticism", defined as the interaction conscientiousness, was following health behaviors: smoking, alcohol consumption, physical activity. Using a pre-registered multi-study coordinated integrative data analysis (IDA)...
We describe three studies that together provide a first approximation to comprehensive taxonomy of unique personality facets. In Study 1, we semantically sorted, removed synonyms, and factor analysed 1772 items taken from seven major omnibus inventories four narrow inventories. 1 identified 61 base 2, conducted systematic review the literature identify facets missing 16 novel then created standardised, open access for 77 3, administered sample ( N = 1096) assessed psychometric properties The...