A5016758271- Fish Ecology and Management Studies
- Environmental Toxicology and Ecotoxicology
- Reproductive biology and impacts on aquatic species
- Ecology and Vegetation Dynamics Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Physiological and biochemical adaptations
- Forest Insect Ecology and Management
- Aquaculture Nutrition and Growth
- Toxic Organic Pollutants Impact
- Pharmacogenetics and Drug Metabolism
- Forest Ecology and Biodiversity Studies
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Genetic diversity and population structure
- Aquaculture disease management and microbiota
- Marine and fisheries research
- Fish Biology and Ecology Studies
- Genetics, Aging, and Longevity in Model Organisms
- Identification and Quantification in Food
- Estrogen and related hormone effects
- Aquatic Invertebrate Ecology and Behavior
- Computational Drug Discovery Methods
- Plant and animal studies
- Effects of Radiation Exposure
- Lung Cancer Treatments and Mutations
McMaster University
2016-2025
Population Health Research Institute
2023
University of Gothenburg
2022
University of Stirling
2018
Marine Scotland
2018
Humber River Regional Hospital
1994-2018
Victoria University of Wellington
2010
Woods Hole Oceanographic Institution
2000-2009
Brock University
2002-2003
Fisheries and Oceans Canada
1999-2001
Background: Andexanet alfa is a modified recombinant inactive factor Xa (FXa) designed to reverse FXa inhibitors. ANNEXA-4 (Andexanet Alfa, Novel Antidote the Anticoagulation Effects of Factor Inhibitors) was multicenter, prospective, phase-3b/4, single-group cohort study that evaluated andexanet in patients with acute major bleeding. The results final analyses are presented. Methods: Patients bleeding within 18 hours inhibitor administration were enrolled. Co-primary end points anti-FXa...
Degraded DNA from suboptimal field sampling is common in molecular ecology. However, its impact on techniques that use restriction site associated next-generation sequencing (RADSeq, GBS) unknown. We experimentally examined the effects of situDNA degradation data generation for a modified double-digest RADSeq approach (3RAD). generated libraries using genomic serially extracted muscle tissue 8 individual lake whitefish (Coregonus clupeaformis) following 0-, 12-, 48- and 96-h incubation at...
PURPOSE This phase II study was designed to assess the effects of mitoxantrone with prednisone in patients metastatic prostate cancer who had progressed on hormonal therapy. The methods assessment included quality-of-life analyses, pain indices, analgesic scores, and National Prostatic Cancer Project (NPCP) criteria. PATIENTS AND METHODS Patients received 12 mg/m2 intravenously every 3 weeks plus 10 mg orally daily. All a castrate serum testosterone Eastern Cooperation Oncology Group (ECOG)...
The Suzuki cross-coupling of aryl boronic acids with halides, including chlorides, proceeds in the phosphonium salt ionic liquid tetradecyltrihexylphosphonium chloride under mild conditions.
Cytochrome P4501 (CYP1) and CYP3A proteins are primarily responsible for the metabolism of 17beta-estradiol (E(2)) in mammals. We have cloned heterologously expressed CYP1A, CYP1B1, CYP1C1, CYP1C2, CYP1D1, CYP3A65 from zebrafish (Danio rerio) to determine CYP-mediated E(2) a non-mammalian species. Constructs each CYP cDNA were created using leader sequence bacterial ompA gene allow appropriate expression Escherichia coli without 5' modification gene. Membrane vesicles purified, functional...
Abstract Background The invasive benthic round goby ( Neogobius melanostomus) is the most successful temperate fish and has spread in aquatic ecosystems on both sides of Atlantic. Invasive species constitute powerful situ experimental systems to study fast adaptation directional selection short ecological timescales present promising case studies understand factors involved impressive ability some colonize novel environments. We seize unique opportunity presented by invasion genomic...
Chronic low-concentration chemical exposures may have both direct health outcomes on adults and indirect effects their offspring. Using zebrafish, we examined the impacts of chronic, carbamazepine (CBZ) exposure a suite male reproductive endpoints in parents four generations offspring reared clean water. CBZ is one most frequently detected pharmaceutical residues water, histone deacetylase inhibitor mammals, reported to lower androgens mammals fish. Exposure adult zebrafish 10 μg/L for 6...
We present a novel PDMS-based microinjection system in microfluidic format with precise electroosmotic dosage control. The device architecture is fully scalable and enables high-throughput microinjections integrated pre- post-processing operations. injection mechanism greatly simplifies current methods as only single degree of freedom required for injections. injections are performed inside enclosed channel by an microneedle. Actuation the needle achieved compliant deformation structure...
The development of diagnostic markers has been a long-standing interest population geneticists as it allows clarification taxonomic uncertainties. Historically, there much debate on the status species belonging to Mytilus complex (M. edulis, M. galloprovincialis and trossulus), whether they are discrete species. We analysed reference pure specimens trossulus, using Restriction site associated DNA (RAD) sequencing identified over 6,000 SNP separating three unambiguously. developed panel for...