A5058948124- Forest Insect Ecology and Management
- Ecology and Vegetation Dynamics Studies
- Forest Ecology and Biodiversity Studies
- Plant and animal studies
- Aquaculture disease management and microbiota
- interferon and immune responses
- MicroRNA in disease regulation
- Plant Taxonomy and Phylogenetics
- Genomics and Phylogenetic Studies
- Zebrafish Biomedical Research Applications
- Invertebrate Immune Response Mechanisms
- Multiple Sclerosis Research Studies
- RNA and protein synthesis mechanisms
- Congenital heart defects research
- Cholesterol and Lipid Metabolism
- Cytokine Signaling Pathways and Interactions
- Lipid metabolism and biosynthesis
- Identification and Quantification in Food
- Digital Imaging for Blood Diseases
- Genetic diversity and population structure
- Ubiquitin and proteasome pathways
- Respiratory viral infections research
- Influenza Virus Research Studies
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
University of Cologne
2019-2024
University of Manitoba
2021-2024
Tallinn University of Technology
2009-2017
Abstract Background The invasive benthic round goby ( Neogobius melanostomus) is the most successful temperate fish and has spread in aquatic ecosystems on both sides of Atlantic. Invasive species constitute powerful situ experimental systems to study fast adaptation directional selection short ecological timescales present promising case studies understand factors involved impressive ability some colonize novel environments. We seize unique opportunity presented by invasion genomic...
Abstract The MHC is a large genetic region controlling Ag processing and recognition by T lymphocytes in vertebrates. Approximately 40% of its genes are implicated innate or adaptive immunity. A putative proto-MHC exists the chordate amphioxus fruit fly, indicating that core predated emergence immune system In this study, we identify with archetypal markers most basal branch Metazoans—the placozoan Trichoplax adhaerens, much older than previously believed—and present common ancestor...
We know from human genetic studies that practically all aspects of biology are strongly influenced by the background, as reflected in advent "personalized medicine." Yet, with few exceptions, this is not taken into account when using laboratory populations animal model systems for research these fields. Laboratory strains zebrafish (Danio rerio) widely used vertebrate developmental biology, behavior, and physiology, modeling diseases, testing pharmaceutic compounds vivo. However, derived...
Abstract Immune cells express powerful and harmful effectors that require tight regulation. Heterotrimeric G proteins are critical mediators in translating extracellular signals into cell responses, which need a fine‐tuned regulation for the control of activation. Regulator ‐protein signalling 16 ( RGS 16) has been identified as key factor protein‐mediated activation lymphocytes, modulating inflammatory survival responses various types. However, data about expression this regulatory protein...
Abstract The zebrafish ( Danio rerio ) is a model vertebrate widely used to study disease, development and other aspects of biology. Most the research performed on laboratory strains, one which has been fully sequenced in order derive reference genome. It known that strains differ genetically from each other, but so far no genome-scale survey variation between wild populations exists. Here we use Restriction-Associated DNA sequencing (RAD-seq) characterize three different lineages population...
Copy number variation in large gene families is well characterized for plant resistance genes, but similar studies are rare animals. The zebrafish ( Danio rerio ) has hundreds of NLR immune making this species ideal studying phenomenon. By sequencing 93 from multiple wild and laboratory populations, we identified a total 1513 NLRs, many more than the previously known 400. Approximately half those present all only 4% were found 80% or individual fish. Wild fish have up to two times as NLRs...
ATP-BINDING CASSETTE SUBFAMILY E MEMBER (ABCE) proteins are one of the most conserved across eukaryotes and archaea. Yeast animals possess a single ABCE gene encoding critical translational factor ABCE1. In several plant species, including Arabidopsis thaliana Oryza sativa , two or more copies have been identified, however information related to family is still missing. this study we retrieved sequences 76 species from public genome databases comprehensively analyzed them with reference A....
Multiple sclerosis (MS) is an inflammatory autoimmune disorder of the central nervous system and leading cause progressive neurological disability in young adults. It decreases patient's lifespan by about 10 years affects women more than men. No medication entirely restricts or reverses degradation. However, early diagnosis treatment increase possibility a better outcome. To identify new MS biomarkers, we tested expression six potential markers (P2X4, P2X7, CXCR4, RGS1, RGS16 VAV1) using...
Many species have hundreds of immune genes from the NLR family (Nucleotide-binding domain Leucine-rich Repeat containing). In plants they a considerable amount within-species variation, but not much is known about their variability in fishes. Here we captured and analysed diversity NLRs zebrafish ( Danio rerio ) by sequencing 93 individuals four wild two laboratory strains. We found 1,560 unique genes, theoretical modelling revealed each population to around 2,000. Only 100-550 were detected...
Abstract ATP-BINDING CASSETTE SUBFAMILY E MEMBER (ABCE) proteins are one of the most conserved across eukaryotes and archaea. Yeast vast majority animals possess a single ABCE gene encoding vital ABCE1 protein. We retrieved sequences 76 plant species from public genome databases analyzed them with reference to Arabidopsis thaliana ABCE2 ( AtABCE2 ). Over half studied two or more genes. There can be as many eight genes in species. This suggest that plants classified low-copy family, rather...
The H1N1 influenza strain Mexico 2009 (H1N1pandemic09) led to mild symptoms (with no or low fever) in Estonia during the 2009-2010 outbreak.Due lack of clinical signs, it was difficult estimate real spreading this virus and cases were officially registered animals either.We used an ELISA method screen blood sample collections for presence anti-H1N1 anti-H3N2 antibodies.All sera also tested with hemagglutination inhibition (HI) assay.Out 123 samples from human patients, 23 (i.e.18.7%)...
Abstract Since the beginning of global trade, hundreds species have colonized territories outside their native range. Some these proliferate at expense ecosystems, i.e., become invasive. Invasive constitute powerful in situ experimental systems to study fast adaptation and directional selection on short ecological timescales. They also present promising case studies for evolutionary success novel environments. We seize this unique opportunity genomic substrates adaptability environments a...