A5071965622- Ecology and Vegetation Dynamics Studies
- Forest Insect Ecology and Management
- Forest Ecology and Biodiversity Studies
- Genetics, Aging, and Longevity in Model Organisms
- Plant and animal studies
- Genomics and Phylogenetic Studies
- Plant Taxonomy and Phylogenetics
- Identification and Quantification in Food
- Epigenetics and DNA Methylation
- Aquaculture disease management and microbiota
- Pluripotent Stem Cells Research
- Reproductive Biology and Fertility
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Genetic diversity and population structure
- CAR-T cell therapy research
- Virus-based gene therapy research
- Cell Image Analysis Techniques
- Genomics and Chromatin Dynamics
- Renal and related cancers
University of Basel
2018-2024
University Children's Hospital Zurich
2023
Friedrich Miescher Institute
2016-2018
Abstract Background The invasive benthic round goby ( Neogobius melanostomus) is the most successful temperate fish and has spread in aquatic ecosystems on both sides of Atlantic. Invasive species constitute powerful situ experimental systems to study fast adaptation directional selection short ecological timescales present promising case studies understand factors involved impressive ability some colonize novel environments. We seize unique opportunity presented by invasion genomic...
Cell-fate reprograming is at the heart of development, yet very little known about molecular mechanisms promoting or inhibiting in intact organisms. In C. elegans germline, germ cells into somatic requires chromatin perturbation. Here, we describe that such facilitated by GLP-1/Notch signaling pathway. This surprising, since this pathway best for maintaining undifferentiated germline stem cells/progenitors. Through a combination genetics, tissue-specific transcriptome analysis, and...
Abstract Recent advances in microscopy have enabled studying chromosome organization at the single-molecule level, yet little is known about inherited organization. Here we adapt tracing to distinguish two C. elegans strains (N2 and HI) find that while their similar, N2 influences folding parameters of HI chromosome, particular step size, across generations. Furthermore, homologous chromosomes overlap frequently, but alignment between regions rare, suggesting transvection unlikely. We...
ABSTRACT During the first hours of embryogenesis, formation higher-order heterochromatin coincides with loss developmental potential. Here, we examine relationship between these two events, and probe processes that contribute to timing their onset. Mutations disrupt histone H3 lysine 9 (H3K9) methyltransferases reveal methyltransferase MET-2 helps terminate plasticity, through mono- di-methylation H3K9 (me1/me2), promotes formation, H3K9me3. Although H3K9me3 perturbs heterochromatin, embryos...
ABSTRACT The Notch signalling pathway is a conserved and widespread paradigm, its misregulation has been implicated in numerous disorders, including cancer. output of depends on the nuclear accumulation receptor intracellular domain (ICD). Using Caenorhabditis elegans germline, where GLP-1/Notch-mediated essential for maintaining stem cells, we monitored GLP-1 vivo. We found that enrichment ICD dynamic: while enriched germ cell nuclei during larval development, it depleted from adult...
Genetic innovation may be linked to evolutionary success, and indeed, the invasive round goby mitochondrial genome sequence carries two novel features not previously described in Benthophilinae. First, a rearrangement of tRNA cluster Ile-Glu-Met. Second, 1250 bp non-coding insertion downstream D-loop region. In this publication, we test where phylogeny arrangement first arose whether is associated with populations only or genuine feature species. We native Europe North America, show that all...
Abstract Since the beginning of global trade, hundreds species have colonized territories outside their native range. Some these proliferate at expense ecosystems, i.e., become invasive. Invasive constitute powerful in situ experimental systems to study fast adaptation and directional selection on short ecological timescales. They also present promising case studies for evolutionary success novel environments. We seize this unique opportunity genomic substrates adaptability environments a...