A5052166991- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- Cerebrovascular and genetic disorders
Massachusetts General Hospital
2019-2024
Harvard University
2023-2024
University of California, Irvine
2018-2022
University of Southern California
2021-2022
University of Michigan
2022
Los Angeles County Department of Health Services
2021-2022
Brigham and Women's Hospital
2022
Wake Forest University
2021
University of Cincinnati
2021
Université de Lille
2021
To clarify whether recurrence risk for intracerebral hemorrhage (ICH) is higher among black and Hispanic individuals this disparity attributable to differences in blood pressure (BP) measurements their variability.We analyzed data from survivors of primary ICH enrolled 2 separate studies: (1) the longitudinal study conducted at Massachusetts General Hospital (n = 759), (2) ERICH (Ethnic/Racial Variations Intracerebral Hemorrhage) 1,532). Participants underwent structured interview enrollment...
Black and Hispanic survivors of intracerebral hemorrhage (ICH) are at higher risk recurrent intracranial bleeding. MRI-based markers chronic cerebral small vessel disease (CSVD) consistently associated with ICH. We therefore sought to investigate whether racial/ethnic differences in MRI-defined CSVD subtype severity contribute disparities ICH recurrence risk.We analyzed data from the Massachusetts General Hospital study (n = 593) Ethnic/Racial Variations Intracerebral Hemorrhage (ERICH)...
For survivors of oral anticoagulation therapy (OAT)-associated intracerebral hemorrhage (OAT-ICH) who are at high risk for thromboembolism, the benefits OAT resumption must be weighed against increased recurrent hemorrhagic stroke. The ε2/ε4 alleles apolipoprotein E (APOE) gene, MRI-defined cortical superficial siderosis, and cerebral microbleeds most potent factors ICH. We sought to determine whether combining MRI markers APOE genotype could have clinical impact by identifying ICH in whom...
<h3>Background and Objectives</h3> Although blood pressure (BP) control is considered the most effective measure to prevent functional decline after intracerebral hemorrhage (ICH), fewer than half of survivors achieve treatment goals. We hypothesized that long-term (i.e., prehemorrhage) hypertension severity may be a crucial factor in explaining poor BP ICH. investigated changes vs before ICH using latent class analysis (LCA) identified patient characteristics predictive individuals9...
Blood pressure (BP) control represents a crucial intervention to improve long-term outcomes following spontaneous intracerebral hemorrhage (ICH). However, fewer than half of ICH survivors achieve target treatment goals. are also at very high risk for poststroke depression, which may contribute inadequate BP control. We, therefore, sought determine whether depressive symptoms after associated with We investigated associations between depression and measurements were mediated by selective...
<h3>Objective:</h3> NA <h3>Background:</h3> Intracerebral hemorrhage (ICH) survivors are at high risk of neurological decline for underlying progressive cerebral small vessel disease (CSVD). Most ICHs attributable to two common CSVD types: amyloid angiopathy (CAA) and hypertensive-CSVD (HTN-CSVD). HTN-CSVD includes pure deep or mixed location ICH/microbleeds, the latter more severe. Hypertension control being most potent intervention delaying CSVD-related ICH progression, we investigated...
Introduction: Intracerebral hemorrhage (ICH) is more prevalent among African American (AA) and Latino/Hispanic (LH) individuals. While ICH survivors are at high risk for rebleeding, it unclear whether recurrence differs based on race / ethnicity. Hypothesis: We sought to clarify: 1) higher AA LH patients; 2) this disparity explained by the most potent factors, i.e. hypertension severity APOE gene variant ε4. Methods: conducted a single-center longitudinal study enrolling 738 presenting...
Introduction: Oldest old (age ≥80 years) survivors of Intracerebral Hemorrhage (ICH) may be at higher risk for stroke recurrence, reflecting increasing hypertension severity with aging. Dedicated longitudinal studies ICH in the oldest are lacking, yet urgently needed as they represent an ever-increasing proportion survivors. We sought to determine whether: 1) recurrence; 2) accounts disparities recurrence across age categories. Methods: analyzed data from primary ICH, enrolled a...
Introduction: Oral Anticoagulation Therapy (OAT) resumption after ICH is a dilemma due to increased risk of recurrent ICH, particularly lobar caused by underlying Cerebral Amyloid Angiopathy (CAA). Apolipoprotein E ( APOE ) ε2/ε4 alleles are factors for CAA-related ICH. Hypothesis: genotype predicts recurrence OAT-ICH. Methods: We enrolled survivors OAT-ICH in prospective single-center study determine whether ε2/ε4: 1) associated with following OAT-ICH, using time-to-event analyses; 2)...