A5015952194- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Cardiovascular Health and Risk Factors
- Stroke Rehabilitation and Recovery
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Organ Transplantation Techniques and Outcomes
- Neurological Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cerebrospinal fluid and hydrocephalus
- Delphi Technique in Research
- Cerebrovascular and genetic disorders
- Neuroethics, Human Enhancement, Biomedical Innovations
- Head and Neck Anomalies
- Healthcare Systems and Practices
- Spinal Hematomas and Complications
- Cognitive Abilities and Testing
- Congenital Heart Disease Studies
- Tracheal and airway disorders
- Social Media in Health Education
Massachusetts General Hospital
2019-2025
Broad Institute
2023-2025
Maharani Laxmi Bai Medical College
2025
Harvard University
2019-2024
University Medical Center Utrecht
2019-2024
Massachusetts Institute of Technology
2024
University of Oxford
2022-2024
University Medical Center
2024
Centre Hospitalier Universitaire de Lille
2020
Thai Red Cross Society
2020
<h3>Objective</h3> To determine whether MRI-based cerebral small vessel disease (CSVD) burden assessment, in addition to clinical and CT data, improved prediction of cognitive impairment after spontaneous intracerebral hemorrhage (ICH). <h3>Methods</h3> We analyzed data from ICH survivors enrolled a single-center prospective study. employed 3 validated CSVD scores: global, amyloid angiopathy (CAA)–specific, hypertensive arteriopathy (HTNA)–specific. quantified performance by administering...
Introduction The 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes lifestyle choices order sustainably reduce the risk of dementia stroke. We aimed assess associations BCS incident Methods derived from United Kingdom Biobank (UKB) baseline evaluation for participants aged 40–69 years, recruited between 2006–2010. Associations subsequent stroke were estimated using Cox proportional hazard...
Background and Purpose- Hematoma location within the cerebellum may help identify dominant small vessel disease type (cerebral amyloid angiopathy [CAA] versus nonamyloid disease). However, it is unknown whether this holds true for cerebral microbleeds (CMBs) cerebellum. We tested hypothesis that cerebellar CMBs restricted to cortex vermis (defined as superficial regions) are associated with clinically diagnosed pathology-verified CAA. Methods- Three hundred seven consecutive spontaneous...
Introduction: Food insecurity, defined as limited access to nutritious food due financial challenges, has grown substantially over the past two decades in United States. Stroke survivors are more likely experience insecurity compared general population. However, impact of on long-term survival post-stroke remains unclear. Hence, we aimed determine associations between and all-cause mortality. Methods: The National Health Nutrition Examination Survey (NHANES) is an iterative cross-sectional...
Background: Trust in healthcare information sources, specifically professionals (HCPs) influences people’s health-related knowledge and behaviors. Epidemiological studies demonstrate that approximately 45% of dementia 60% stroke risks are attributable to modifiable risk factors. However, limited data exist on associations between trust levels HCPs perceptions the modifiability from a United States cohort. Methods: We developed survey based validated questionnaires distributed it cohort all...
Background: Dementia and stroke are major contributors to mortality morbidity, largely due modifiable risk factors. Despite widespread awareness, health-related behaviors that reduce these risks remain suboptimal. This study aims (i) cluster characterize subgroups based on their recognition of factors associated for dementia stroke, (ii) identify the corresponding facilitators barriers. Methods: We conducted an online survey U.S. population via Prolific. Participants were assessed...
Background: The Brain Care Score (BCS) is a novel tool developed to address modifiable risk factors for the incidence of age-related brain diseases such as stroke, dementia, and late-life depression (LLD) (Fig 1) . Previous data showed that lower baseline BCS associated with higher disease risks. This study examines associations between longitudinal changes on these three outcomes. Methods: UK Biobank (UKB) participants primary care available assessment 19-point modified were included. We...
Introduction: Stroke and dementia are among the leading causes of mortality globally. This can be mitigated through targeting modifiable risk factors. Identification those at-risk screening tools could facilitated by inclusion self-reported factors rather than reliance on clinical data. We aimed to determine whether reliable in identifying individuals predict stroke dementia-related mortality. Methods: In this study cross-sectional data from National Health Nutrition Examination Survey...
Introduction: Of all strokes, 25% are attributable to recurrent events, of which 80% can be prevented by adherence secondary prevention guidelines. These involve managing and controlling risk factors for recurrence, such as blood pressure, body mass index (BMI), low-density lipoprotein (LDL) cholesterol, glycated hemoglobin (HbA1c), smoking, alcohol consumption physical activity. We aimed determine proportion stroke survivors adheres standard AHA guidelines factor management, the trends in...
Introduction: Atrial fibrillation diagnosed after stroke (AFDAS) is common and differs from known atrial (KAF), the most cause of cardioembolic stroke. Because identification AFDAS warrants administration oral anticoagulants for secondary prevention, extended cardiac monitoring often used, yet it unclear who at risk developing AFDAS. We aimed to determine whether prediction improves when adding genetic clinical predictors in a real world population survivors. Methods: retrospectively...
Introduction: Stroke, dementia, and late-life depression (LLD) are age-related brain diseases that pose significant public health challenges. Leukocyte telomere length (LTL), a proposed marker of biological age influenced by complex interplay both lifestyle heritable factors, may offer valuable insights into the modifiability risk for these diseases. We aimed to study association between LTL three outcomes, whether healthy choices modify this risk. Methods: utilized data from UK Biobank...
Background: Since treatment with anticoagulants can prevent recurrent strokes, identification of patients at risk for incident AF after stroke is crucial. We aimed to investigate whether the addition polygenic scores (PRS) existing clinical predictors could improve prediction stroke. Methods: Patients diagnosed ischemic Massachusetts General Hospital between 2003-2017 were included. Clinical was estimated using Re-CHARGE-AF model and genetic a contemporary PRS from 1,093,050 variants....
Introduction- stature is nature height a person in upright position. Stature or body very important anthropometric parameter by which physical identity of an individual can be done when where unknown dead found with destroy face mummied/ putreed unrecognizable. Aim- human marked from long bones humerus, radius ,ulna, femur , tibia. If total more than bone that also have length so there relation bones. So this if somewhere singled single extremity as natural disaster – tsunami earthquake...
Background Stroke and dementia are leading causes of mortality can be prevented through risk factor management. Risk assessment requires laboratory or physical measurements. We aimed to determine whether self‐reported factors serve as reliable proxies predict stroke‐ dementia‐related mortality. Methods Results used cross‐sectional data from the NHANES (National Health Nutrition Examination Survey) 1999 2018 linked National Death Index records. included participants with available on measured...
Spontaneous intracerebral hemorrhage (ICH) in the cerebellum has a poor short-term prognosis, whereas data on long-term case fatality and recurrent vascular events are sparse. Herewith, we aimed to assess recurrence rate of after first cerebellar ICH.
Introduction: Whether stroke survivors can meet risk factor recommendations set by guidelines is unknown. We investigated the proportion of that met secondary prevention guideline recommendations, analyzed trends over time, and assessed impact on mortality. Methods: Using cross-sectional data from National Health Nutrition Examination Survey (NHANES) 1999-2018, we determined who recommendations. performed linear regression analyses to determine Cox-proportional hazards models assess Results:...
Secondary prevention interventions to reduce post-stroke cognitive impairment (PSCI) can be aided by the early identification of high-risk individuals who would benefit from risk factor modification.
Cerebral amyloid angiopathy (CAA) accounts for the majority of lobar intracerebral hemorrhage (ICH); however, risk factors dementia conversion after ICH occurrence in CAA patients are unknown, especially long-term period ICH. Therefore, we aimed to unravel predictors late post-ICH (6 months event) probable patients.From a large consecutive MRI prospective cohort spontaneous (2006-2017), identified (modified Boston criteria) without 6 post-ICH. Cognitive outcome during follow-up was...
Introduction: The 21-point Brain Care Score (BCS), developed via a modified Delphi process with practitioners and patients, is novel instrument designed to motivate behavioral lifestyle changes, ultimately aiming decrease incidence of dementia stroke (Fig 1). Whether or not BCS components are associated longitudinal changes in mood disorders clear. For this study, we tested the hypothesis that also significantly correlates late-life depression UK Biobank (UKB). Design / Methods: was derived...