A5017058524- Genetic Associations and Epidemiology
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Veterinary Medicine and Surgery
- COVID-19 Clinical Research Studies
- Chronic Disease Management Strategies
- Nutrition and Health in Aging
- Obesity, Physical Activity, Diet
- Ophthalmology and Visual Impairment Studies
- Health disparities and outcomes
- Nutritional Studies and Diet
- Body Composition Measurement Techniques
- Nutrition, Genetics, and Disease
- Lipoproteins and Cardiovascular Health
- Delphi Technique in Research
- Global Cancer Incidence and Screening
- Veterinary Equine Medical Research
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- Veterinary Orthopedics and Neurology
- Veterinary Pharmacology and Anesthesia
- Health, Environment, Cognitive Aging
- Molecular Biology Techniques and Applications
- Retinal Imaging and Analysis
- Cardiovascular Conditions and Treatments
University of Oxford
2019-2025
UK Biobank
2019-2025
University of Cambridge
2022
MRC Epidemiology Unit
2022
University of Bristol
2022
MRC Biostatistics Unit
2022
University of Tennessee Health Science Center
2022
Royal Veterinary College
2018-2019
Abstract Ready access to health research studies is becoming more important as researchers, and their funders, seek maximize the opportunities for scientific innovation improvements. Large‐scale population‐based prospective are particularly useful multidisciplinary into causes, treatment prevention of many different diseases. UK Biobank has been established an open‐access resource public research, with intention making data widely available possible in equitable transparent manner. Access...
Objectives To investigate whether people with coeliac disease are at increased risk of cardiovascular disease, including ischaemic heart myocardial infarction, and stroke. Design Prospective analysis a large cohort study. Setting UK Biobank database. Participants 469 095 adults, which 2083 had aged 40-69 years from England, Scotland, Wales between 2006 2010 without baseline. Main outcome measure A composite primary was relative stroke in compared who do not have assessed using Cox...
The independent effect of waist-to-height ratio (WHtR) and body fat percentage (BF%) on ischemic cardiovascular disease (CVD) remains uncertain.
Higher levels of vegetable consumption have been associated with a lower risk cardiovascular disease (CVD), but the independent effect raw and cooked remains unclear.From UK Biobank cohort, 399,586 participants without prior CVD were included in analysis. Raw intakes measured validated dietary questionnaire at baseline. Multivariable Cox regression was used to estimate associations between intake incidence mortality, adjusted for socioeconomic status, health lifestyle factors. The potential...
Individual conditions have been identified as risk factors for dementia; however, it is important to consider the role of multimorbidity, often co-occur.To investigate whether multimorbidity associated with incident dementia and associations vary by different clusters disease genetic dementia.This population-based prospective cohort study used data from UK Biobank cohort, baseline collected between 2006 2010 up 15 years follow-up. Participants included women men without aged at least 60...
Introduction The 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes lifestyle choices order sustainably reduce the risk of dementia stroke. We aimed assess associations BCS incident Methods derived from United Kingdom Biobank (UKB) baseline evaluation for participants aged 40–69 years, recruited between 2006–2010. Associations subsequent stroke were estimated using Cox proportional hazard...
To estimate the incidence proportion of road traffic accidents in cats attending emergency out-of-hours clinics UK, identify major risk factors for accident occurrence and survival to discharge.A retrospective study a cohort 33,053 VetCompass database emergency-care practice between January 1, 2012 February 15, 2014. Incidence was calculated logistic regression used discharge following accident.Incidence estimated at 4∙2% (95% confidence interval: 4∙0 4∙4%). Cats aged 6 months 2 years were...
Chronic kidney disease (CKD) is a frequent diagnosis in cats attending primary care practice and the most cause of death aged over five years, yet there limited published research for CKD practice. This study aimed to estimate prevalence investigate risk factors survival diagnosed with UK practices. The included VetCompassTM practices from January 1, 2012 December 31, 2013. A nested case-control cohort were undertaken. From 353,448 244 clinics, was estimated as 1.2 per cent (95 CI 1.1 1.3...
Background Little is known about the persistence of antibodies after first year following SARS-CoV-2 infection. We aimed to determine proportion individuals that maintain detectable levels over an 18-month period Methods Population-based prospective study 20 000 UK Biobank participants and their adult relatives recruited in May 2020. The cases testing positive for immunoglobulin G (IgG) against spike protein (IgG-S), nucleocapsid (IgG-N), was calculated at varying intervals Results Overall,...
Abstract Background There is a possibility that an incorrect diagnosis of hypothyroidism could be made in euthyroid dogs, and the prevalence dog population remains unknown. Objectives To retrospectively assess percentage dogs diagnosed with, treated for, at first opinion practice which are likely to hypothyroid require levothyroxine supplementation. Animals One hundred two client‐owned were included this study. Materials Methods The computerized databases 7 practices searched identify with...
Background Hypertension is common in older cats. There limited evidence for predictors of survival after diagnosis. Hypothesis/Objectives Investigate blood pressure assessment (BPA) and hypertension diagnosis cats attending UK primary care practices (PCPs) factors that influence survival. Animals Cats (347 889) 244 PCPs enrolled the VetCompass program between January 1, 2012, December 31, 2013. identified as hypertensive (282) were included descriptive analyses. Methods All electronic...
Abstract UK Biobank is an intensively characterized prospective study of 500 000 men and women, aged 40 to 69 years when recruited, between 2006 2010, from the general population United Kingdom. Established as open-access resource for researchers worldwide perform health research that in public interest, has collected (and continues collect) a vast amount data on genetic, physiological, lifestyle, environmental factors, with prolonged follow-up heath conditions through linkage administrative...
Abstract Visual impairment has emerged as a potential modifiable risk factor for dementia. However, there is lack of large studies with objective measures vision and more than 10 years follow-up. We investigated whether visual associated an increased incident dementia in UK Biobank European Prospective Investigation into Cancer Norfolk (EPIC-Norfolk). In both cohorts, acuity was measured using “logarithm the minimum angle resolution” (LogMAR) chart categorized no (≤0.30 LogMAR), mild...
Abstract Background Whilst multi-morbidity is known to be a concern in people with cancer, very little about the risk of cancer multi-morbid patients. This study aims investigate being diagnosed lung, colorectal, breast and prostate associated multi-morbidity. Methods We investigated association between subsequent diagnosis UK Biobank. Cox models were used estimate relative risks each interest participants, using Cambridge Multimorbidity Score. The extent which reverse causation, residual...
To investigate associations between health-related behaviors as measured using the Brain Care Score (BCS) and neuroimaging markers of white matter injury.
Previous studies have suggested that there is a theoretical discrepancy between the cage size and resultant tibial tuberosity advancement, with consistently providing less advancement than predicted. The purpose of this study was to test quantify in clinical cases. hypothesis as measured by widening proximal tibia at level after standard TTA, will be sized used, no particular relative smaller or higher under-advancement, conformation an influence on amount achieved. One hundred sixty-four...
The 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers take action reduce the risk of stroke dementia by motivating lifestyle changes (Fig 1). In this study we aimed assess if BCS also associated with brain on MRI in people who have not yet developed or stroke. Methods: This was conducted within substudy longitudinal cohort UK Biobank. assessed neuroimaging markers included: volume, white matter hyperintensities (WMH) fractional anisotropy...
Background: The Brain Care Score (BCS) was developed through a modified Delphi process with practitioners and patients for implementation into primary care to stimulate behavioral changes lifestyle choices sustainably reduce the incidence of dementia stroke ( Fig 1) . Methods: To assess its validity as associated stroke, BCS derived from UK Biobank (UKB) baseline evaluation (2006-2010) participants aged 40-69. Cox proportional hazards regression were used estimate associations between...
Abstract Background: Multi-morbidity (MM), which is usually defined as a simple count of the number different diseases an individual has, has previously been identified risk factor for some incident cancer diagnoses. This study aimed to use more sophisticated machine learning techniques classify MM into disease clusters and investigate their association with colorectal (CRC), breast (BC), lung (LC) prostate (PrC) Methods: Participants in UK Biobank hospital (HES) record no prevalent were...