A5058789676- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Risk Factors
- Intracerebral and Subarachnoid Hemorrhage Research
- Health, Environment, Cognitive Aging
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Diet and metabolism studies
- Venous Thromboembolism Diagnosis and Management
- Vascular Malformations Diagnosis and Treatment
- Frailty in Older Adults
- Folate and B Vitamins Research
- Genetic Associations and Epidemiology
- Health disparities and outcomes
- LGBTQ Health, Identity, and Policy
- Birth, Development, and Health
- Health Systems, Economic Evaluations, Quality of Life
- Cerebrospinal fluid and hydrocephalus
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Pituitary Gland Disorders and Treatments
- Dental Health and Care Utilization
- Epigenetics and DNA Methylation
- Meningioma and schwannoma management
Yale University
2021-2025
Yale Cancer Center
2024-2025
Neurological Surgery
2024
University of New Haven
2024
Medical University of Warsaw
2023-2024
University of Massachusetts Chan Medical School
2023
Quinnipiac University
2023
Hospital de Clínicas "José de San Martín"
2019-2021
University of Buenos Aires
2021
Santobono Children's Hospital
2020
Importance Stroke is a leading cause of death and disability in the US. Accurate updated measures stroke burden are needed to guide public health policies. Objective To present estimates ischemic hemorrhagic US 2019 describe trends from 1990 by age, sex, geographic location. Design, Setting, Participants An in-depth cross-sectional analysis Global Burden Disease study was conducted. The setting included time period encompassed for various types strokes, including all intracerebral...
Abstract Summary Here we present Genal, a python module for population genetic analyses. It includes functionalities cleaning and formatting Single Nucleotide Polymorphism (SNP)-level data, clumping, lifting, SNP association testing, polygenic risk scoring, mendelian randomization analyses, all within single module. was designed with user-friendliness in mind, aiming to reduce the programming skills threshold required medical scientists perform epidemiology studies. Genal eliminates need...
Background: White Matter Hyperintensities (WMH) are a radiographic manifestation of cerebral small vessel disease (CSVD), representing myelin and axonal loss. Currently, no drugs specifically target or reduce the burden WMH. Integrating genomic proteomic data may identify proteins as potential targets to slow WMH progression. Particularly promising that serve pathway-level hubs through which polygenic effects converge. Methods: We analyzed from 53,014 participants enrolled in UK Biobank. The...
Background: Stroke patients are at risk for secondary vascular events, but factor control is often insufficient. Vascular factors like hypertension, diabetes, and hyperlipidemia highly heritable, persons with higher polygenic predisposition less likely to achieve control. The combined impact of these effects on clinical management stroke unknown. Hypothesis: We hypothesize that the effect most important leads rates treatment failure events in survivors. Methods: In our genetic association...
Type 2 diabetes mellitus (T2DM) is highly genetically determined, and polygenic susceptibility to T2DM (PSD) increases the risk of worse glycemic control adverse vascular outcomes. Its role in stroke patients remains unknown. We aim determine whether higher PSD associated with survivors. conducted a 2-stage genetic association study. In cross-sectional design, we selected survivors from UK Biobank (enrollment between 2006 2010) evaluate relationship control. Second, replicated results using...
Chronological age is an imperfect estimate of molecular aging. Epigenetic age, derived from DNA methylation data, provides a more nuanced representation aging-related biological processes. We examine the bidirectional relationship between epigenetic and brain health events (stroke, dementia, late-life depression) using data 4,018 participants. Participants with prior event are 4% epigenetically older (β = 0.04, SE 0.01), indicating these conditions associated accelerated aging beyond that...
Background: Ischemic stroke result in significant morbidity and mortality. By examining gene expression of cells comprising clots, we aim to gain valuable insights into the underlying mechanisms this disease identify potential biomarkers etiology. Methods: We employed single-cell RNA sequencing analyze 10 clot samples from patients diagnosed with large vessel occlusion stroke. aimed compare immune cell compositions profiles between clots (atrial fibrillation vs carotid atherosclerosis). also...
INTRODUCTION: In an era of increasingly diverse neurosurgical workforce, one the key challenges recognized is need to ensure fair and equitable pay. METHODS: We performed a retrospective study American Association Medical Colleges (AAMS) Faculty Salary Survey, years 2017 2023. Financial compensation data for full-time academic faculty were stratified by rank, gender, race/ethnicity. The total was calculated sum fixed/contractual salary, medical malpractice supplement, bonus/incentive...
INTRODUCTION: While recent evidence has demonstrated the safety and efficacy of endovascular thrombectomy (EVT) for acute basilar artery occlusions, few studies have explored benefit EVT posterior cerebral (PCA) occlusions. METHODS: The Nationwide Readmission Database years 2020 2021 was queried. Adult patients (>17 old) undergoing PCA occlusions were identified using ICD-10-CM coding system. Unique patient linkage numbers used to follow identify readmission rates. Patients grouped by no...
INTRODUCTION: In 2018, the JC and AHA introduced a new stroke care certification for Thrombectomy-Capable Stroke Centers, increasing both access number of proceduralists performing endovascular thrombectomies(EVT) nationwide. However, dispersing overall volume centers located in close proximity may have unclear effects on patient outcome. METHODS: We performed retrospective cohort study using 2020 Florida State Inpatient Database. included adult patients who had diagnosis AIS underwent EVT...
INTRODUCTION: Several series have reported on the complication rates of diagnostic cerebral angiography (DCA). Changes in procedural indications, catheter technologies, and access methods necessitate an investigation into demographics complications DCA a modern practice. METHODS: A retrospective review was conducted patients who underwent between 2013 2020. Demographics, clinical information, were collected. Multivariate analysis utilized to identify potential factors associated with...
INTRODUCTION: Transcarotid artery revascularization (TCAR) has been established as an effective surgical option for symptomatic carotid disease, relying on flow reversal a proximal neuroprotection strategy. Despite its effectiveness, may not be tolerated in certain patients. These include those with anatomic variations the intracranial circulation, such isolated cerebral hemisphere, and multiple cranio-cervical occlusions. In other cases, efficient cannot certainty, e.g., when treating...
Background The aim of this study was to evaluate the preliminary experience a combined middle meningeal artery embolization (MMAE) and burr hole evacuation approach for chronic subdural hematoma (cSDH) under single anesthesia session. Methods We performed retrospective review all patients who underwent MMAE surgery during same admission at major academic institution between 2019 2024. Patients were dichotomized by those with both procedures session (combined) or two separate sessions...
Aim To use the Hospital Frailty Risk Score (HFRS) to investigate impact of frailty on complication rates and healthcare resource utilization in patients who underwent endovascular treatment ruptured intracranial aneurysms (IAs). Methods A retrospective cohort study was performed using 2016–2019 National Inpatient Sample database. All adult (≥18 years) undergoing for IAs after subarachnoid hemorrhage were identified ICD-10-CM codes. Patients categorized into cohorts: low (HFRS <5),...
Frailty is a prevalent state associated with several aging-related traits and conditions. The relationship between frailty stroke remains understudied. Here we aim to investigate whether the hospital risk score (HFRS) of determine significant association genetically determined exists.
Sexual and gender minority (SGM) groups have been historically underrepresented in neurologic research, their brain health disparities are unknown. We aim to evaluate whether SGM persons at higher risk of adverse outcomes compared with cisgender straight (non-SGM) individuals.
BACKGROUND AND OBJECTIVES: First pass effect (FPE) is a metric increasingly used to determine the success of mechanical thrombectomy (MT) procedures. However, few studies have investigated whether duration procedure can modify clinical benefit FPE. We sought FPE after MT for anterior circulation large vessel occlusion acute ischemic stroke modified by procedural time (PT). METHODS: A multicenter, international data set was retrospectively analyzed treated who achieved excellent reperfusion...
The aim of this study was to determine the impact endovascular thrombectomy (EVT) proceduralist volume on in-hospital mortality in acute ischemic stroke (AIS) patients.
Background The American Heart Association's Life's Simple 7, a public health construct capturing key determinants of cardiovascular health, became the Essential 8 after addition sleep duration. authors tested hypothesis that suboptimal duration is associated with poorer neuroimaging brain profiles in asymptomatic middle‐aged adults. Methods and Results conducted prospective magnetic resonance study individuals without stroke or dementia enrolled UK Biobank. Self‐reported was categorized as...
Carotid revascularization is an important method of stroke prevention and includes carotid endarterectomy transfemoral angioplasty stenting. More recently, a hybrid open-endovascular approach, termed transcarotid artery (TCAR), garnering increased attention. Although fundamentally ‘stenting procedure’, unlike stenting, TCAR allows for proximal neuroprotection strategy based on flow reversal. In this technical video, we will review operative techniques nuances the procedure, with particular...