A5034880165- Cancer-related molecular mechanisms research
- Nutritional Studies and Diet
- Genetic Associations and Epidemiology
- Nutrition and Health in Aging
- Endometrial and Cervical Cancer Treatments
- COVID-19 Clinical Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Risks and Factors
- Diabetes and associated disorders
- Obesity, Physical Activity, Diet
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Body Composition Measurement Techniques
- SARS-CoV-2 and COVID-19 Research
- Body Contouring and Surgery
- Cardiovascular Disease and Adiposity
- COVID-19 epidemiological studies
- Cancer Genomics and Diagnostics
- Consumer Attitudes and Food Labeling
- Electrical and Bioimpedance Tomography
- Lipoproteins and Cardiovascular Health
- Estrogen and related hormone effects
- Vitamin C and Antioxidants Research
- Vitamin D Research Studies
University of Oxford
2019-2024
UK Biobank
2024
Nuffield Health
2023
Open Data Institute
2023
University of Bristol
2022
MRC Biostatistics Unit
2022
University of Cambridge
2022
MRC Epidemiology Unit
2022
University of Tennessee Health Science Center
2022
University of Ibadan
2017
The independent effect of waist-to-height ratio (WHtR) and body fat percentage (BF%) on ischemic cardiovascular disease (CVD) remains uncertain.
Higher levels of vegetable consumption have been associated with a lower risk cardiovascular disease (CVD), but the independent effect raw and cooked remains unclear.From UK Biobank cohort, 399,586 participants without prior CVD were included in analysis. Raw intakes measured validated dietary questionnaire at baseline. Multivariable Cox regression was used to estimate associations between intake incidence mortality, adjusted for socioeconomic status, health lifestyle factors. The potential...
Background Little is known about the persistence of antibodies after first year following SARS-CoV-2 infection. We aimed to determine proportion individuals that maintain detectable levels over an 18-month period Methods Population-based prospective study 20 000 UK Biobank participants and their adult relatives recruited in May 2020. The cases testing positive for immunoglobulin G (IgG) against spike protein (IgG-S), nucleocapsid (IgG-N), was calculated at varying intervals Results Overall,...
Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it unknown if this association causal or confounded. To further elucidate the role of in risk, we conducted complementary observational and Mendelian randomization (MR) analyses.
Previous studies on the association of adiposity with endometrial cancer risk have mostly used body mass index (BMI) as main exposure interest. Whether more precise measures fat, such fat percentage and estimated by bioimpedance analyses, are better indicators than BMI is unknown. The role central fat-free in development remains unclear. We Cox regression models to estimate hazard ratios (HR) corresponding 95% confidence intervals (CI) for associations various size/composition among 135 110...
Abstract UK Biobank is an intensively characterized prospective study of 500 000 men and women, aged 40 to 69 years when recruited, between 2006 2010, from the general population United Kingdom. Established as open-access resource for researchers worldwide perform health research that in public interest, has collected (and continues collect) a vast amount data on genetic, physiological, lifestyle, environmental factors, with prolonged follow-up heath conditions through linkage administrative...
Objective: This study evaluated the effects of a 12-month dietary modification on indices inflammation and pro-thrombosis in adults with metabolic syndrome (MS).Materials methods: longitudinal involved 252 MS recruited from Bodija market, Ibadan its environs. Participants were placed 20%, 30% 50% calories obtained protein, total fat carbohydrate respectively followed up monthly for 12 months. Anthropometry blood pressure measured using standard methods. Fasting plasma glucose (FPG),...
Background The social determinants of ethnic disparities in risk SARS-CoV-2 infection during the first wave pandemic UK remain unclear. Methods In May 2020, a total 20 195 adults were recruited from general population into Biobank Serology Study. Between mid-May and mid-November participants provided monthly blood samples. At end study, completed questionnaire on factors different periods pandemic. Logistic regression yielded ORs for association between ethnicity immunoglobulin G antibodies...
Abstract Body mass index (BMI; weight (kg)/height (m)2) is commonly used to measure general adiposity. However, evidence of its appropriateness for males and females remains inconsistent. We aimed identify the most appropriate sex-specific power value that height should be raised in formula would make it achieve independency body fatness dependency. randomly assigned UK Biobank participants recruited United Kingdom between 2006 2010 (n = 489,873; mean age 56.5 years; 94.2% White) training...
Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the levels of alterations in inflammation different status is presently lacking. Aim. To determine TNF-α, assess their possible relationship with gender individuals MS. Material methods. Sixty adults MS 40 controls were enrolled into this case-control study. Serum TNF-α measured participants stratified status....
Background: Observational studies have demonstrated inverse associations between vegetable intake and cardiovascular diseases. However, the results are prone to residual confounding. The separate effects of cooked raw remain unclear. This study aims investigate association with outcomes using Mendelian randomization (MR). Methods: We identified 15 28 genetic variants associated statistically biologically intake, which were used as instrumental variables estimate coronary heart disease (CHD),...
Abstract UK Biobank is an intensively characterised prospective cohort of 500,000 adults aged 40–69 years when recruited between 2006 and 2010. The study was established to enable researchers worldwide undertake health-related research in the public interest. existence such a large, detailed with high degree participant engagement enabled its rapid repurposing for coronavirus disease-2019 (COVID-19) research. In response pandemic, frequency updates on hospitalisations deaths among...
Abstract Background Bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) are used commonly for assessing body composition. This study aimed to evaluate the agreement between BIA DXA measures assess validity of in UK Biobank. Methods Biobank participants with fat mass (FM) free (FFM) estimates derived from performed on same date were included. DXA-derived compared using Pearson correlation coefficients. Bland-Altman was quantify differences its distribution....
<h3>Background</h3> Obesity, as reflected by a high body mass index (BMI), is well-known risk factor for endometrial cancer. Whether more precise measures of fat, such fat percentage and assessed bioelectrical impedance analysis, are strongly related to unknown has not been explored in any prospective study. In addition, the independent role distribution development cancer remains unclear. <h3>Methods</h3> We analysed data from 202,796 women UK Biobank, aged 40–69 years at study entry....