A5020114412- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Bacteriophages and microbial interactions
- Vibrio bacteria research studies
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Combustion and flame dynamics
- Genetic Associations and Epidemiology
- Organic and Molecular Conductors Research
- Monoclonal and Polyclonal Antibodies Research
- Bacterial biofilms and quorum sensing
- Animal Nutrition and Physiology
- Advanced Combustion Engine Technologies
- Genetic and phenotypic traits in livestock
- Distributed and Parallel Computing Systems
- Nonlinear Optical Materials Research
- Clostridium difficile and Clostridium perfringens research
- Asthma and respiratory diseases
- Computer Graphics and Visualization Techniques
- Trace Elements in Health
- Extracellular vesicles in disease
- Plant Pathogenic Bacteria Studies
MRC Biostatistics Unit
2020-2024
University of Cambridge
2015-2024
The University of Sydney
2023
University of Oxford
2001-2022
University of Bristol
2022
MRC Epidemiology Unit
2022
University of Tennessee Health Science Center
2022
Winthrop University
2021
Medical Research Council
2020
The University of Texas Medical Branch at Galveston
1981-2016
Mechanistic determinants of bacterial growth, death, and spread within mammalian hosts cannot be fully resolved studying a single population. They are also currently poorly understood. Here, we report on the application sophisticated experimental approaches to map spatiotemporal population dynamics bacteria during an infection. We analyzed heterogeneous traits simultaneous infections with tagged Salmonella enterica populations (wild-type isogenic strains [WITS]) in wild-type gene-targeted...
After concerns about the possible toxicity of thimerosal-containing vaccines in United States, this study was designed to investigate whether there is a relationship between amount thimerosal that an infant receives via diphtheria-tetanus-whole-cell pertussis (DTP) or diphtheria-tetanus (DT) vaccination at young age and subsequent neurodevelopmental disorders.A retrospective cohort performed using 109 863 children who were born from 1988 1997 registered general practices Kingdom contributed...
Salmonella enterica sv. typhimurium (S. Typhimurium) has two metal-transporting P1-type ATPases whose actions largely overlap with respect to growth in elevated copper. Mutants lacking both over-accumulate copper relative wild-type or either single mutant. Such duplication of is unusual bacterial tolerance. Both are under the control MerR family metal-responsive transcriptional activators. Analyses periplasmic complexes identified copper-CueP as one predominant metal pools. Expression cueP...
Salmonella bacteria can tolerate antibiotics by adopting a slow-growing "persister" state that hides in host dendritic cells and re-initiate infection after treatment ends. This be avoided supplementing antibiotic with stimulants of innate immunity.
Campylobacter jejuni is a major cause of bacterial gastroenteritis worldwide, primarily associated with the consumption contaminated poultry. C. lineages vary in host range and prevalence human infection, suggesting differences survival throughout poultry processing chain. From 7343 MLST-characterised isolates, we sequenced 600 coli isolates from various stages clinical cases. A genome-wide association study (GWAS) ST-21 ST-45 complexes identified genetic elements over-represented that...
Abstract Background The world faces a major infectious disease challenge. Interest in the discovery, design, or development of antimicrobial peptides (AMPs) as an alternative approach for treatment bacterial infections has increased. Insects are good source AMPs which main effector molecules their innate immune system. Black Soldier Fly Larvae (BSFL) being developed large-scale rearing food sustainability, waste reduction and sustainable animal fish feed. Bioinformatic studies have suggested...
Room-temperature electrical resistivity and Hall effect measurements as a function of pressure are reported on p-type MoS2 n-type MoS2, MoSe2 MoTe2. In each case, the decreases under pressure, due to an increase in carrier concentration. The mobility is relatively pressure-independent. data consistent with predominance extrinsic conduction these semiconductors until well above room temperature. impurity activation energy its dependence given, together estimates intrinsic indirect bandgap...
An understanding of how pathogens colonize their hosts is crucial for the rational design vaccines or therapy. While molecular factors facilitating invasion and systemic infection by are a central focus research in microbiology, population biological aspects colonization still poorly understood. Here, we investigated early dynamics Salmonella enterica subspecies 1 serovar Typhimurium (S. Tm) streptomycin mouse model diarrhea. We focused on first step way to — cecal lymph node (cLN) from gut...
Abstract A reduced diversity of the gastrointestinal commensal microbiota is associated with development several inflammatory diseases. Recent reports in humans and animal models have demonstrated beneficial therapeutic effects infections by parasitic worms (helminths) some disorders, such as bowel disease (IBD) coeliac (CeD). Interestingly, these studies described how helminths may alter intestinal microbiota, potentially representing a mechanism which they regulate inflammation. However,...
Summary BipA is a novel member of the ribosome binding GTPase superfamily and widely distributed in bacteria plants. We report here that it regulates multiple cell surface‐ virulence‐associated components enteropathogenic Escherichia coli (EPEC) strain E2348/69. The regulated components include bacterial flagella, espC pathogenicity island type III secretion system specified by locus enterocyte effacement (LEE). positively LEE gene clusters through transcriptional control L EE‐ e ncoded r...
Campylobacter jejuni is a prevalent cause of food-borne diarrhoeal illness in humans. Understanding the physiological and metabolic capabilities organism limited. We report detailed analysis C. growth cycle batch culture. Combined transcriptomic, phenotypic demonstrates highly dynamic 'stationary phase', characterized by peak motility, numerous gene expression changes substrate switching, despite transcript that indicate downshift upon onset stationary phase. Video tracking bacterial...
Background GABAA receptors are members of the Cys-loop family neurotransmitter receptors, proteins which responsible for fast synaptic transmission, and site action wide range drugs [1]. Recent work has shown that present on immune cells, but their physiological roles effects modify function in innate system currently unclear [2]. We interested how why anaesthetics increase infections intensive care patients; a serious problem as more than 50% patients with severe sepsis will die [3]–[6]. As...
Intracellular replication within specialized vacuoles and cell-to-cell spread in the tissue are essential for virulence of Salmonella enterica. By observing infection dynamics at single-cell level vivo, we have discovered that pathogenicity island 2 (SPI-2) type 3 secretory system (T3SS) is dispensable growth to high intracellular densities. This challenges concept absolutely requires proteins delivered by SPI-2 T3SS, which has been derived largely inference from vitro cell experiments...
Fashion content generation is an emerging area at the intersection of artificial intelligence and creative design, with applications ranging from virtual try-on to culturally diverse design prototyping. Existing methods often struggle cultural bias, limited scalability, alignment between textual prompts generated visuals, particularly under weak supervision. In this work, we propose a novel framework that integrates Large Language Models (LLMs) Latent Diffusion (LDMs) address these...
We report the functional characterization of BipA, a GTPase that undergoes tyrosine phosphorylation in an enteropathogenic Escherichia coli (EPEC) strain. BipA − mutants adhere to cultured epithelial cells but fail trigger characteristic cytoskeletal rearrangements found infected with wild‐type EPEC. In contrast, increased expression enhances actin remodelling and results hyperformation pseudopods. appears be first example new class virulence regulator, as it also controls flagella‐mediated...