A5034678530- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Hematological disorders and diagnostics
- Tuberculosis Research and Epidemiology
- Trace Elements in Health
- HIV-related health complications and treatments
- Blood donation and transfusion practices
- Blood transfusion and management
- Prenatal Screening and Diagnostics
- Bone and Joint Diseases
- Chronic Lymphocytic Leukemia Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Lymphoma Diagnosis and Treatment
- Malaria Research and Control
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Vitamin D Research Studies
- HIV, Drug Use, Sexual Risk
- Erythropoietin and Anemia Treatment
- Mosquito-borne diseases and control
- Healthcare Systems and Technology
- Digital Imaging for Blood Diseases
- Neurological and metabolic disorders
University College Hospital, Ibadan
2009-2024
University of Ibadan
2013-2024
Ladoke Akintola University of Technology
2023
Scientific and Technological Research Council of Turkey
2010
Although Nigeria has the highest burden of sickle cell disease (SCD) worldwide, there is still variable and poor utilisation standard-of-care practices for SCD patients in country. This was a questionnaire survey doctors some dedicated clinics order to document facilities available common management practices. There were responses from 18 based 11 institutions. The number being followed each centre ranged 15 approximately 000. All provided malaria prophylaxis folic acid routinely their...
Sickle cell disease (SCD) is a neglected burden of growing importance. >312,000 births are affected annually by sickle anaemia (SCA). Early interventions such as newborn screening, penicillin prophylaxis and hydroxyurea can substantially reduce the mortality morbidity associated with SCD. Nevertheless, their implementation in African countries has been mostly limited to pilot projects. Recent development low-cost point-of-care testing (POCT) devices for haemoglobin (HbS) could greatly...
Enantia chlorantha (EC) is sought after by the rural communities in South Western Nigeria and some other African countries for treatment of many ailments. Despite its widespread use, phytochemical Gas Chromatography-Mass Spectrometry (GC-MS) screening fermented maize aqueous extract remain undetermined. This study was carried out with aim to evaluate GC-MS analysis plant stem bark. The using standard methods while identification quantification bioactive components were determined...
Homozygous sickle cell disease (genotype HbSS) confers a certain degree of protection to human (especially Africans) Plasmodium falciparum malaria, yet the precise mechanism remains unknown. Recent observations suggest that might also involve immune and non-immune components. In this study, plasma levels trace elements (Mg, Fe, Zn, Mn, Cu, Cr, Cd Se) antioxidants (urea, albumin total antioxidants) were determined in Nigerians with (HbSS+M), or without (HbSS-M) parasitaemia, haemoglobin AA...
Sickle cell disease affects about 150,000 births annually in Nigeria. Early diagnosis is hampered by factors such as centralized and urban localization of laboratories, high cost diagnostic equipment inadequate skilled manpower to operate them. The need for a low-cost, portable, easy-to-use test sickle critical, especially resource-poor countries. In this study, we evaluated the performance characteristics novel point-of-care testing device (SickleSCAN™), its acceptability feasibility,...
Inflammatory markers that influence bone pain crisis (BPC) and other complications of sickle cell anaemia (SCA) are numerous play various roles. This study determined the plasma levels tumour necrosis factor (TNF) - α, interleukin 8 (IL-8), endothelin 1 (ET-1) in adult SCA patients during BPC steady state. In addition, these cytokines were correlated with severity patients.Sixty (30 30 state) haemoglobin A controls enrolled for this cross-sectional study. The was assessed clinically,...
Background Sickle cell disease (SCD) is a major genetic that manifests early in life and may lead to significant morbidities. One of the health care services have been effective reducing burden SCD developed countries newborn screening (NBS) followed by pneumococcal vaccines, penicillin prophylaxis, hydroxyurea treatment. Yet, sub-Saharan African countries, where about 75% annual affected babies worldwide are born, NBS programmes largely unavailable. It not clear whether this due technical...
Objective This study assessed the diagnostic performance and prognostic properties of C-reactive protein (CRP), copeptin cortisol in individuals with sickle cell anaemia (SCA). Design Prospective case-control Methods Sixty consecutive SCA subjects (18–40 years) comprising 30 steady state vaso-occlusive crisis (VOC) were recruited into this study. Thirty (30) apparently healthy HbAA genotype served as controls. ELISA was used for determination serum levels copeptin, CRP cortisol. Data...
This study was designed to determine the plasma levels of some antioxidants and trace elements in three severity groups HIV patients compared with non-HIV-infected controls.The (total antioxidant, albumin, bilirubin uric acid) (Mg, Fe, Zn, Mn, Cu, Cr, Cd Se) were estimated spectrophotometrically controls CD4 counts <200; 200-499 > or =500 cells/microl.Uric acid Zn significantly higher, while vitamin E all (except Zn) lower HIV-infected healthy controls. The highest level observed those <200...
Metabolic syndrome (MS) amplifies hypertension (HTN) associated with increased risk of cardiovascular disease (CVD). MS components and other CVD measures were investigated in different stages hypertension. 534 apparently healthy Nigerian traders aged 18–105 years participants a cohort study. The International Diabetes Federation (2005) the National High Blood Pressure Education Program Coordinating Committee criteria used for HTN classifications, respectively. Anthropometric indices obtained...
Hepatobiliary and splenic complications (amongst others) are common in sickle cell disease (SCD) as a consequence of the progressive injury resulting from repeated sickling HbS red blood cells.To determine degree frequency persistent hepatomegaly splenomegaly relation to determinants clinical severity patients with SCD.Two hundred twenty SCD steady state were assessed for presence size palpably enlarged spleen liver. Patients or re-assessed after three months. Average was recorded well...
Background: Metabolic Syndrome (MS) increases the risk of developing type-2 diabetes (DM2) and cardiovascular diseases (CVD) it is thought to be prevalent in Nigeria.This study aims at determining prevalence MS its component factors among apparently healthy traders a local market Ibadan, Nigeria.Methods: 534 from Bodija, Nigeria aged (18-105) years with neither DM2 nor CVD were participants cohort on assessment type 2 dementia Nigerians metabolic syndrome.The International Diabetes...
Chronic inflammation and elevated basal metabolic rate (BMR) are established features of sickle-cell anemia (SCA). However, there is little information on the possible impacts these afore-mentioned glycemia insulin sensitivity status this group people.This study aims to determine as well effect BMR in adults with SCA steady state.Fifty participants comprising 30 state 20 age- gender-matched apparently healthy hemoglobin genotype AA (HbAA) that served controls. Anthropometric clinical indices...
Background: Sickle cell anaemia (SCA) patients are prone to require long-term frequent blood transfusion because of chronic haemolysis and overlapping hyper-haemolysis. Hence, they become vulnerable iron overload its complications. On the other hand, deficiency has been documented among un-transfused SCA cases. Thus, there is a need effectively efficiently determine status patients. Objective: We investigated whether adult in steady state (SSt) or those with vaso-occlusive crisis (VOC) have...
Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder associated with vaso-occlusive events, oxidative stress, high energy demand, and endothelial dysfunction. The endothelium plays a central role in the regulation of vascular homeostasis by releasing nitric oxide (NO) among other factors. Therefore, objective this study was to measure plasma levels NO, trace metals, HbF SCD patients. Materials methods: Plasma Zn, Mg, Mn, Se, Cu, Fe, Haemoglobin F (HbF) were measured 59 steady...
Introduction Pulmonary hypertension is emerging as one of the causes morbidity and mortality in adults with sickle cell disease. The prevalence pulmonary Nigerian anaemia unknown. We decided to estimate artery systolic diastolic pressures subjects seen at University College Hospital, Ibadan, Nigeria, determine frequency among them.Methods Ninety patients (38 males 52 females) steady state comparable age- sex-matched normal controls had a clinical evaluation echocardiographic...
Background and objectives: Sickle cell disease(SCD) is a disorder of red cells resulting from the co-inheritance hae- moglobin S (HbS) with another abnormal haemoglobin. The diagnosis acute leukaemia uncommon in our patients sickle disease more so have high morbidity mortality due to sickling process.Acute leukemia malignant clonal haemopoietic precursor accumulation immature blood bone marrow blood.The objective case series was highlight challenges management SCD leukaemia, importance...
Objective: This study evaluated the effects of a 12-month dietary modification on indices inflammation and pro-thrombosis in adults with metabolic syndrome (MS).Materials methods: longitudinal involved 252 MS recruited from Bodija market, Ibadan its environs. Participants were placed 20%, 30% 50% calories obtained protein, total fat carbohydrate respectively followed up monthly for 12 months. Anthropometry blood pressure measured using standard methods. Fasting plasma glucose (FPG),...