A5004560548- Dementia and Cognitive Impairment Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Neurobiology of Language and Bilingualism
- Parkinson's Disease Mechanisms and Treatments
- Health disparities and outcomes
- Neurosurgical Procedures and Complications
- Posttraumatic Stress Disorder Research
- Voice and Speech Disorders
- Cholinesterase and Neurodegenerative Diseases
- Mindfulness and Compassion Interventions
- COVID-19 and Mental Health
- Retirement, Disability, and Employment
- Cardiac Arrhythmias and Treatments
- Balance, Gait, and Falls Prevention
- Health, Environment, Cognitive Aging
- Decision-Making and Behavioral Economics
- Motivation and Self-Concept in Sports
- Sleep and Wakefulness Research
- Sleep and related disorders
- Aging and Gerontology Research
- Sleep and Work-Related Fatigue
- Technology Use by Older Adults
- Blood Pressure and Hypertension Studies
University of Maine
2020-2024
Dana-Farber Cancer Institute
2024
University of Pennsylvania
2016-2022
Penn Center for AIDS Research
2018-2022
Gates (United States)
2018
Neurology, Inc
2017
Massachusetts General Hospital
2010-2013
Universitat Autònoma de Barcelona
2013
Harvard University
2010-2012
KU Leuven
2010
Cerebral amyloid angiopathy (CAA) typically presents with lobar intracerebral macrohemorrhages (ICH) or microbleeds (MBs). Several case reports also found superficial siderosis (SS) in patients CAA. We aimed to assess the value of SS for vivo diagnosis CAA, and tested whether inclusion as a criterion alters sensitivity specificity Boston criteria CAA-related hemorrhage.We retrospectively analyzed T2*-weighted MRIs 38 histopathologically proven CAA 22 control non-CAA ICHs regarding presence...
<b>Objective:</b> To identify and compare clinical neuroimaging predictors of primary lobar intracerebral hemorrhage (ICH) recurrence, assessing their relative contributions to recurrent ICH. <b>Methods:</b> Subjects were consecutive survivors ICH drawn from a single-center prospective cohort study. Baseline clinical, imaging, laboratory data collected. Survivors followed prospectively for intercurrent aspirin warfarin use, including duration exposure. Cox proportional hazards models used...
Abstract Objective: In addition to its role in hemorrhagic stroke, advanced cerebral amyloid angiopathy (CAA) is also associated with ischemic lesions and vascular cognitive impairment. We used functional magnetic resonance imaging (MRI) techniques identify CAA‐associated dysfunction. Methods: Functional MRI was performed on 25 nondemented subjects probable CAA (mean ± standard deviation age, 70.2 7.8 years) 12 healthy elderly controls (age, 75.3 6.2 years). Parameters measured were...
<h3>Objective:</h3> To investigate whether the topography of dilated perivascular spaces (DPVS) corresponds with markers particular small-vessel diseases such as cerebral amyloid angiopathy and hypertensive vasculopathy. <h3>Methods:</h3> Patients were recruited from an ongoing single-center prospective longitudinal cohort study patients evaluated in a memory clinic. All underwent structural, high-resolution MRI, had clinical assessment performed within 1 year scan. DPVS rated basal ganglia...
<h3>Objective:</h3> We aimed to determine whether amyloid imaging can help predict the location and number of future hemorrhages in cerebral angiopathy (CAA). <h3>Methods:</h3> performed a longitudinal cohort study 11 patients with CAA without dementia who underwent serial brain MRIs after baseline Pittsburgh compound B (PiB). Mean distribution volume ratio (DVR) PiB was determined at sites new micro/macrobleeds identified on follow-up MRI compared retention “simulated” hemorrhages, randomly...
Background and Purpose— MRI evidence of small vessel disease is common in intracerebral hemorrhage (ICH). We hypothesized that ICH caused by cerebral amyloid angiopathy (CAA) or hypertensive vasculopathy would have different distributions T2 white matter hyperintensity (WMH) microbleeds. Methods— Data were analyzed from 133 consecutive patients with primary supratentorial adequate sequences. CAA was diagnosed using the Boston criteria. WMH segmentation performed a validated semiautomated...
Abstract Objectives: Adverse childhood experiences (ACE) are associated with an increased risk for dementia, but this relationship and modifying factors poorly understood. This study is the first to our knowledge comprehensively examine effect of ACE on specific cognitive functions measures greater resiliency decline in independent community-dwelling older adults. Methods: Verbal/nonverbal intelligence, verbal memory, visual executive attention were assessed. Self-report examined depression,...
Mild cognitive impairment and dementia are clinically heterogeneous disorders influenced by diverse risk factors. Improved characterization of the effect multiple factors influence on specific functions may improve understanding mechanisms in early change lead to more effective interventions.Structural equation modeling (SEM) simultaneously examined effects modifiable (education, depression, metabolic/vascular risk) nonmodifiable (age, sex, apolipoprotein E-ɛ4 allele [APOE-e4] status)...
Background: An understudied variant of Alzheimer’s disease (AD), the behavioral/dysexecutive AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy. Objective: This study characterizes neuropsychological neuroanatomical features bvAD by comparing it to behavioral frontotemporal dementia (bvFTD), amnestic (aAD), subjects normal cognition. Methods: Subjects included 16 bvAD, 67 bvFTD, 18 aAD patients, 26 healthy controls....
Slowed gait is one of the strongest predictors fall risk in older adults. The present study investigated whether speed mediated relationship between depression and history 147 adults presenting to a memory clinic for cognitive complaints. Depression, status, speed, number falls within last year were primary measures. Results revealed fallers, relative non-fallers, had slower higher scores. As hypothesized, analyses using PROCESS macro found that history. Additionally, combination mild...
Objectives The current study investigated trait mindfulness associations with distinct aspects of executive function. We also aimed to characterize relationships between measures psychological risk and resilience within adults aged 55–87 years.Method In this cross-sectional study, 121 completed neuropsychological working memory, mental set-shifting, inhibition, as well a battery well-validated self-report measures. Mindful Attention Awareness Scale (MAAS) measured mindfulness.Results Trait...
BACKGROUND: Day-to-day interactions depend on conversational narrative, and we examine here the neurobiological basis for difficulty organizing narrative discourse in patients with Lewy body disorders (LBD). METHOD: Narrative organization was examined 56 non-aphasic LBD patients, including a non-demented cohort (n=30) Parkinson's disease (PD) or PD-Mild Cognitive Impairment PD-MCI), mild dementia (n=26) PD-dementia (PDD) bodies (DLB), similar age education but differing MMSE (p<0.001). We...
BACKGROUND: While primary progressive aphasia (PPA) is associated with frontotemporal lobar degeneration (FTLD) pathology due to tau or TDP, clinical-pathological studies also demonstrate many cases have Alzheimer's disease (AD) pathology. The logopenic variant of PPA (lvPPA) most often AD pathology, but this has proven be the least reliable diagnose using published clinical criteria. In study, we used cerebrospinal fluid (CSF) analytes identify patients likely and relate phenotypic features...
Sleep health and executive function are multifaceted constructs that decline with age. Some evidence suggests poor sleep may underlie declines in function, but this relationship is not consistently found cognitively normal older adults. The authors systematically investigated distinct domain associations specific aspects of function.Community-dwelling adults completed clinical interviews, comprehensive neuropsychological assessments, subjective measures. Four domains were investigated:...
Contextually driven decision making is multidimensional, as individuals need to contend with prioritizing both competing and complementary demands. However, data limited whether temporal discounting rates vary a function of framing (gains vs loss) domain (monetary social) in middle-to-older aged adults. It also unclear socioaffective characteristics like social isolation loneliness are associated discounting. Temporal were examined across monetary gain, loss, loss conditions 140 adults 50-90...
Abstract Objective The National Institutes of Health Toolbox-Cognition Battery (NIHTB-CB) is an efficient computerized neuropsychological battery. This study investigated its psychometric properties in terms sociodemographic characteristics and technology use adults aged 57–87 (with average age 70). Methods Community-based participatory research procedures were used to enhance enrollment with lower education income backgrounds. Study replicated work that compared the NIHTB-CB Crystallized...
OBJECTIVE: To evaluate whether progressive supranuclear palsy (PSP) have social cognition limitations using the Social Norms Questionnaire (SNQ). BACKGROUND: Progressive Supranuclear Palsy is predominantly considered a Parkinson-Plus movement disorder that may additionally present with cognitive such as mental rigidity. However, relative deficits of dysfunction been under investigated. In contrast, Parkinson’s disease (PD) shares many features PSP but typically has sparing features. We...
Objective: When deciding between now and later, the tendency to devalue later outcomes is known as temporal discounting. The degree of devaluing one’s discounting rate. Steeper rates indicate preferences for immediate gains delayed losses, reflecting a desire instant gratification greater loss aversion, respectfully. Considering that decrements in decision-making abilities may precipitate cognitive dysfunction decline, better understanding among older adults represents an important endeavor....
Background and Purpose: Cerebral Amyloid Angiopathy (CAA), characterized by accumulation of amyloid beta proteins in the walls cortical/leptomeningeal vessels, is increasingly recognized as a cause ischemic brain injury addition to its classical role lobar cerebral hemorrhages (ICH). Pittsburgh Compound B (PiB) PET ligand that has been shown label vascular deposits CAA, allowing invivo quantification severity CAA pathology. We hypothesized there would be dose-dependent relationship between...
To compare the utility of The Philadelphia Brief Assessment Cognition (PBAC), Mini-Mental State Examination (MMSE) and Montreal Cognitive (MoCA) to detect dementia amyloid-beta (Aβ) pathology in Lewy body disorders (LBD), including Parkinson's disease (PD), PD with mild cognitive impairment (PD-MCI), (PDD), bodies (DLB).